Assessment of Structural Intolerance and Durability
General Structure Information 1few DIABLO crystal structure of smac/diablo 2.2Å AUTH J.CHAI,C.DU,J.W.WU,S.KYIN,X.WANG,Y.SHITITL STRUCTURAL AND BIOCHEMICAL BASIS OF APOPTOTIC ACTIVATION BYTITL 2 SMAC/DIABLO.REF NATURE V. 406 855 2000REFN ISSN 0028-0836PMID 10972280DOI 10.1038/35022514 Variant Set Distributions Mapped Variants
General Structure Information 3t6p BIRC2 iap antagonist-induced conformational change in ciap1 promotes e3 ligase activation via dimerization 1.9Å AUTH E.C.DUEBER,A.J.SCHOEFFLER,A.LINGEL,J.M.ELLIOTT,A.V.FEDOROVA,AUTH 2 A.M.GIANNETTI,K.ZOBEL,B.MAURER,E.VARFOLOMEEV,P.WU,AUTH 3 H.J.WALLWEBER,S.G.HYMOWITZ,K.DESHAYES,D.VUCIC,AUTH 4 W.J.FAIRBROTHERTITL ANTAGONISTS INDUCE A CONFORMATIONAL CHANGE IN CIAP1 THATTITL 2 PROMOTES AUTOUBIQUITINATION.REF SCIENCE V. 334 376 2011REFN ISSN 0036-8075PMID 22021857DOI 10.1126/SCIENCE.1207862 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3g76 XIAP crystal structure of xiap-bir3 in complex with a bivalent compound 3.0Å AUTH F.COSSU,M.MILANI,E.MASTRANGELO,P.VACHETTE,AUTH 2 F.SERVIDA,D.LECIS,G.CANEVARI,D.DELIA,C.DRAGO,AUTH 3 V.RIZZO,L.MANZONI,P.SENECI,C.SCOLASTICO,M.BOLOGNESITITL STRUCTURAL BASIS FOR BIVALENT SMAC-MIMETICSTITL 2 RECOGNITION IN THE IAP PROTEIN FAMILYREF J.MOL.BIOL. V. 392 630 2009REFN ISSN 0022-2836PMID 19393243DOI 10.1016/J.JMB.2009.04.033 Variant Set Distributions Mapped Variants