Assessment of Structural Intolerance and Durability
General Structure Information 2iwn MPDZ 3rd pdz domain of multiple pdz domain protein mpdz (casp target) 1.35Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,AUTH 2 C.PHILLIPS,C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINEDTITL 2 WITH THE HELP OF SELF-BINDING C-TERMINALTITL 3 EXTENSION.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 2zne PDCD6 crystal structure of zn2+-bound form of des3-23alg-2 complexed with alix abs peptide 2.2Å AUTH H.SUZUKI,M.KAWASAKI,T.INUZUKA,M.OKUMURA,T.KAKIUCHI,AUTH 2 H.SHIBATA,S.WAKATSUKI,M.MAKITITL STRUCTURAL BASIS FOR CA(2+)-DEPENDENT FORMATION OFTITL 2 ALG-2/ALIX PEPTIDE COMPLEX: CA(2+)/EF3-DRIVENTITL 3 ARGININE SWITCH MECHANISMREF STRUCTURE V. 16 1562 2008REFN ISSN 0969-2126PMID 18940611DOI 10.1016/J.STR.2008.07.012 Variant Set Distributions Mapped Variants
General Structure Information 2vyi SGTA crystal structure of the tpr domain of human sgt 2.4Å AUTH S.DUTTA,Y.J.TANTITL STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OFTITL 2 HUMAN SGT AND ITS INTERACTION WITH VPU OF THETITL 3 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1.REF BIOCHEMISTRY V. 47 10123 2008REFN ISSN 0006-2960PMID 18759457DOI 10.1021/BI800758A Variant Set Distributions Mapped Variants
General Structure Information 3ikk VAPB crystal structure analysis of msp domain 2.5Å AUTH J.SHI,S.LUA,J.S.TONG,J.SONGTITL ELIMINATION OF THE NATIVE STRUCTURE AND SOLUBILITY OF THETITL 2 HVAPB MSP DOMAIN BY THE PRO56SER MUTATION THAT CAUSESTITL 3 AMYOTROPHIC LATERAL SCLEROSIS.REF BIOCHEMISTRY V. 49 3887 2010REFN ISSN 0006-2960PMID 20377183DOI 10.1021/BI902057A Variant Set Distributions Mapped Variants
General Structure Information 3gb8 XPO1 crystal structure of crm1/snurportin-1 complex 2.9Å AUTH X.DONG,A.BISWAS,K.E.SUEL,L.K.JACKSON,R.MARTINEZ,H.GU,AUTH 2 Y.M.CHOOKTITL STRUCTURAL BASIS FOR LEUCINE-RICH NUCLEAR EXPORT SIGNALTITL 2 RECOGNITION BY CRM1.REF NATURE V. 458 1136 2009REFN ISSN 0028-0836PMID 19339969DOI 10.1038/NATURE07975 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants