Assessment of Structural Intolerance and Durability
General Structure Information 4hhv COL4A3BP crystal structure of ceramide transfer protein pleckstrin homology domain 1.75Å AUTH J.PRASHEK,T.TRUONG,X.YAOTITL CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM THETITL 2 CERAMIDE TRANSFER PROTEIN: IMPLICATIONS FOR CONFORMATIONALTITL 3 CHANGE UPON LIGAND BINDING.REF PLOS ONE V. 8 79590 2013REFN ESSN 1932-6203PMID 24260258DOI 10.1371/JOURNAL.PONE.0079590 Variant Set Distributions Mapped Variants
General Structure Information 2d86 VAV3 solution structure of the ch domain from human vav-3 protein -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CH DOMAIN FROM HUMANTITL 2 VAV-3 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cre CASS4 solution structure of rsgi ruh-036, an sh3 domain from human cdna -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-036, AN SH3 DOMAINTITL 2 FROM HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dkp PLEKHA5 solution structure of the ph domain of pleckstrin homology domain-containing protein family a member 5 from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PLECKSTRINTITL 2 HOMOLOGY DOMAIN-CONTAINING PROTEIN FAMILY A MEMBERTITL 3 5 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ve7 SPC25 crystal structure of a bonsai version of the human ndc80 complex 2.88Å AUTH C.CIFERRI,S.PASQUALATO,E.SCREPANTI,G.VARETTI,S.SANTAGUIDA,AUTH 2 G.DOS REIS,A.MAIOLICA,J.POLKA,J.G.DE LUCA,P.DE WULF,M.SALEK,AUTH 3 J.RAPPSILBER,C.A.MOORES,E.D.SALMON,A.MUSACCHIOTITL IMPLICATIONS FOR KINETOCHORE-MICROTUBULE ATTACHMENT FROMTITL 2 THE STRUCTURE OF AN ENGINEERED NDC80 COMPLEXREF CELL(CAMBRIDGE,MASS.) V. 133 427 2008REFN ISSN 0092-8674PMID 18455984DOI 10.1016/J.CELL.2008.03.020 Variant Set Distributions Mapped Variants
General Structure Information 1r42 ACE2 native human angiotensin converting enzyme-related carboxypeptidase (ace2) 2.2Å AUTH P.TOWLER,B.STAKER,S.G.PRASAD,S.MENON,J.TANG,T.PARSONS,AUTH 2 D.RYAN,M.FISHER,D.WILLIAMS,N.A.DALES,M.A.PATANE,AUTH 3 M.W.PANTOLIANOTITL ACE2 X-RAY STRUCTURES REVEAL A LARGE HINGE-BENDING MOTIONTITL 2 IMPORTANT FOR INHIBITOR BINDING AND CATALYSIS.REF J.BIOL.CHEM. V. 279 17996 2004REFN ISSN 0021-9258PMID 14754895DOI 10.1074/JBC.M311191200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2p0f ARHGAP9 arhgap9 ph domain in complex with ins(1,3,5)p3 1.91Å AUTH D.F.CECCARELLI,I.M.BLASUTIG,M.GOUDREAULT,Z.LI,AUTH 2 J.RUSTON,T.PAWSON,F.SICHERITITL NON-CANONICAL INTERACTION OF PHOSPHOINOSITIDESTITL 2 WITH PLECKSTRIN HOMOLOGY DOMAINS OF TIAM1 ANDTITL 3 ARHGAP9.REF J.BIOL.CHEM. V. 282 13864 2007REFN ISSN 0021-9258PMID 17339315DOI 10.1074/JBC.M700505200 Variant Set Distributions Mapped Variants
General Structure Information 3n1g BOC crystal structure of dhhn bound to bocfn3 1.9Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Mapped Variants
General Structure Information 1v88 OSBPL8 solution structure of the pleckstrin homology domain of oxysterol-binding protein-related protein 8 (kiaa1451 protein) -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF OXYSTEROL-BINDING PROTEIN-RELATEDTITL 3 PROTEIN 8 (KIAA1451 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3mb3 PHIP crystal structure of the second bromodomain of pleckstrin homology domain interacting protein (phip) 2.25Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants