Assessment of Structural Intolerance and Durability
General Structure Information 4ndg APTX human aprataxin (aptx) bound to rna-dna and zn – adenosine vanadate transition state mimic complex 2.54Å AUTH P.TUMBALE,J.S.WILLIAMS,M.J.SCHELLENBERG,T.A.KUNKEL,AUTH 2 R.S.WILLIAMSTITL APRATAXIN RESOLVES ADENYLATED RNA-DNA JUNCTIONS TO MAINTAINTITL 2 GENOME INTEGRITY.REF NATURE V. 506 111 2013REFN ISSN 0028-0836PMID 24362567DOI 10.1038/NATURE12824 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1av5 HINT1 pkci-substrate analog 2.0Å AUTH C.D.LIMA,M.G.KLEIN,W.A.HENDRICKSONTITL STRUCTURE-BASED ANALYSIS OF CATALYSIS ANDTITL 2 SUBSTRATE DEFINITION IN THE HIT PROTEIN FAMILY.REF SCIENCE V. 278 286 1997REFN ISSN 0036-8075PMID 9323207DOI 10.1126/SCIENCE.278.5336.286 Variant Set Distributions Mapped Variants
General Structure Information 4fit FHIT fhit-apo 2.5Å AUTH C.D.LIMA,M.G.KLEIN,W.A.HENDRICKSONTITL STRUCTURE-BASED ANALYSIS OF CATALYSIS ANDTITL 2 SUBSTRATE DEFINITION IN THE HIT PROTEIN FAMILY.REF SCIENCE V. 278 286 1997REFN ISSN 0036-8075PMID 9323207DOI 10.1126/SCIENCE.278.5336.286 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants