Assessment of Structural Intolerance and Durability
General Structure Information 3ray PRDM11 crystal structure of methyltransferase domain of human pr domain- containing protein 11 1.73Å AUTH A.DONG,H.ZENG,P.LOPPNAU,J.R.WALKER,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WU,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN PRTITL 2 DOMAIN-CONTAINING PROTEIN 11REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2r3a SUV39H2 methyltransferase domain of human suppressor of variegation 3-9 homolog 2 2.0Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3f9y SETD8 structural insights into lysine multiple methylation by set domain methyltransferases, set8-y334f / h4-lys20me1 / adohcy 1.5Å AUTH J.F.COUTURE,L.M.DIRK,J.S.BRUNZELLE,R.L.HOUTZ,R.C.TRIEVELTITL STRUCTURAL ORIGINS FOR THE PRODUCT SPECIFICITY OF SET DOMAINTITL 2 PROTEIN METHYLTRANSFERASES.REF PROC.NATL.ACAD.SCI.USA V. 105 20659 2008REFN ISSN 0027-8424PMID 19088188DOI 10.1073/PNAS.0806712105 Variant Set Distributions Mapped Variants
General Structure Information 2rfi EHMT1 crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide 1.59Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3ewf HDAC8 crystal structure analysis of human hdac8 h143a variant complexed with substrate. 2.5Å AUTH D.P.DOWLING,S.L.GANTT,S.G.GATTIS,C.A.FIERKE,AUTH 2 D.W.CHRISTIANSONTITL STRUCTURAL STUDIES OF HUMAN HISTONE DEACETYLASE 8TITL 2 AND ITS SITE-SPECIFIC VARIANTS COMPLEXED WITHTITL 3 SUBSTRATE AND INHIBITORS.REF BIOCHEMISTRY V. 47 13554 2008REFN ISSN 0006-2960PMID 19053282DOI 10.1021/BI801610C Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 4llb KAT6A crystal structure of moz double phd finger histone h3k14ac complex 2.5Å AUTH I.DREVENY,S.E.DEEVES,J.FULTON,B.YUE,M.MESSMER,AUTH 2 A.BHATTACHARYA,H.M.COLLINS,D.M.HEERYTITL THE DOUBLE PHD FINGER DOMAIN OF MOZ/MYST3 INDUCESTITL 2 ALPHA-HELICAL STRUCTURE OF THE HISTONE H3 TAIL TO FACILITATETITL 3 ACETYLATION AND METHYLATION SAMPLING AND MODIFICATION.REF NUCLEIC ACIDS RES. V. 42 822 2014REFN ISSN 0305-1048PMID 24150941DOI […]
General Structure Information 2ou2 KAT5 acetyltransferase domain of human hiv-1 tat interacting protein, 60kda, isoform 3 2.3Å AUTH H.WU,J.MIN,L.DOMBROVSKI,P.LOPPNAU,J.WEIGELT,AUTH 2 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF ACETYLTRANSFERASE DOMAINTITL 2 OF HUMAN HIV-1 TAT INTERACTING PROTEIN IN COMPLEXTITL 3 WITH ACETYLCOENZYME A.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rnx KAT2B the structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human transcriptional co-activators pcaf and cbp -1.0Å AUTH L.ZENG,Q.ZHANG,G.GERONA-NAVARRO,N.MOSHKINA,M.M.ZHOUTITL STRUCTURAL BASIS OF SITE-SPECIFIC HISTONETITL 2 RECOGNITION BY THE BROMODOMAINS OF HUMANTITL 3 COACTIVATORS PCAF AND CBP/P300REF STRUCTURE V. 16 643 2008REFN ISSN 0969-2126PMID 18400184DOI 10.1016/J.STR.2008.01.010 Variant Set […]
General Structure Information 3c0y HDAC7 crystal structure of catalytic domain of human histone deacetylase hdac7 2.1Å AUTH A.SCHUETZ,J.MIN,A.ALLALI-HASSANI,M.SCHAPIRA,AUTH 2 M.SHUEN,P.LOPPNAU,R.MAZITSCHEK,N.P.KWIATKOWSKI,AUTH 3 T.A.LEWIS,R.L.MAGLATHIN,T.H.MCLEAN,A.BOCHKAREV,AUTH 4 A.N.PLOTNIKOV,M.VEDADI,C.H.ARROWSMITHTITL HUMAN HDAC7 HARBORS A CLASS IIA HISTONETITL 2 DEACETYLASE-SPECIFIC ZINC BINDING MOTIF AND CRYPTICTITL 3 DEACETYLASE ACTIVITY.REF J.BIOL.CHEM. V. 283 11355 2008REFN ISSN 0021-9258PMID 18285338DOI 10.1074/JBC.M707362200 Variant Set Distributions Mapped Variants
General Structure Information 4ly1 HDAC2 structure of human hdac2 in complex with inhibitor 4-(acetylamino)-n- [2-amino-5-(thiophen-2-yl)phenyl]benzamide 1.57Å AUTH B.E.LAUFFER,R.MINTZER,R.FONG,S.MUKUND,C.TAM,I.ZILBERLEYB,AUTH 2 B.FLICKE,A.RITSCHER,G.FEDOROWICZ,R.VALLERO,D.F.ORTWINE,AUTH 3 J.GUNZNER,Z.MODRUSAN,L.NEUMANN,C.M.KOTH,P.J.LUPARDUS,AUTH 4 J.S.KAMINKER,C.E.HEISE,P.STEINERTITL HISTONE DEACETYLASE (HDAC) INHIBITOR KINETIC RATE CONSTANTSTITL 2 CORRELATE WITH CELLULAR HISTONE ACETYLATION BUT NOTTITL 3 TRANSCRIPTION AND CELL VIABILITY.REF J.BIOL.CHEM. V. 288 26926 2013REFN ISSN 0021-9258PMID 23897821DOI 10.1074/JBC.M113.490706 Variant Set […]