Assessment of Structural Intolerance and Durability
General Structure Information 3n06 PRLR a mutant human prolactin receptor antagonist h27a in complex with the extracellular domain of the human prolactin receptor 2.0Å AUTH M.V.KULKARNI,M.C.TETTAMANZI,J.W.MURPHY,C.KEELER,D.G.MYSZKA,AUTH 2 N.E.CHAYEN,E.J.LOLIS,M.E.HODSDONTITL TWO INDEPENDENT HISTIDINES, ONE IN HUMAN PROLACTIN AND ONETITL 2 IN ITS RECEPTOR, ARE CRITICAL FOR PH-DEPENDENT RECEPTORTITL 3 RECOGNITION AND ACTIVATION.REF J.BIOL.CHEM. V. 285 38524 2010REFN […]
General Structure Information 3n06 PRL a mutant human prolactin receptor antagonist h27a in complex with the extracellular domain of the human prolactin receptor 2.0Å AUTH M.V.KULKARNI,M.C.TETTAMANZI,J.W.MURPHY,C.KEELER,D.G.MYSZKA,AUTH 2 N.E.CHAYEN,E.J.LOLIS,M.E.HODSDONTITL TWO INDEPENDENT HISTIDINES, ONE IN HUMAN PROLACTIN AND ONETITL 2 IN ITS RECEPTOR, ARE CRITICAL FOR PH-DEPENDENT RECEPTORTITL 3 RECOGNITION AND ACTIVATION.REF J.BIOL.CHEM. V. 285 38524 2010REFN […]
General Structure Information 1eer EPO crystal structure of human erythropoietin complexed to its receptor at 1.9 angstroms 1.9Å AUTH R.S.SYED,S.W.REID,C.LI,J.C.CHEETHAM,K.H.AOKI,B.LIU,AUTH 2 H.ZHAN,T.D.OSSLUND,A.J.CHIRINO,J.ZHANG,AUTH 3 J.FINER-MOORE,S.ELLIOTT,K.SITNEY,B.A.KATZ,AUTH 4 D.J.MATTHEWS,J.J.WENDOLOSKI,J.EGRIE,R.M.STROUDTITL EFFICIENCY OF SIGNALLING THROUGH CYTOKINETITL 2 RECEPTORS DEPENDS CRITICALLY ON RECEPTORTITL 3 ORIENTATION.REF NATURE V. 395 511 1998REFN ISSN 0028-0836PMID 9774108DOI 10.1038/26773 Variant Set Distributions Ripley’s K Analysis Plots […]