Assessment of Structural Intolerance and Durability
General Structure Information 2dk3 HECTD1 solution structure of mib-herc2 domain in hect domain containing protein 1 -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF MIB-HERC2 DOMAIN IN HECTTITL 2 DOMAIN CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3jw0 NEDD4L e2~ubiquitin-hect 3.1Å AUTH H.B.KAMADURAI,J.SOUPHRON,D.C.SCOTT,D.M.DUDA,D.J.MILLER,AUTH 2 D.STRINGER,R.C.PIPER,B.A.SCHULMANTITL INSIGHTS INTO UBIQUITIN TRANSFER CASCADES FROM A STRUCTURETITL 2 OF A UBCH5B APPROXIMATELY UBIQUITIN-HECT(NEDD4L) COMPLEX.REF MOL.CELL V. 36 1095 2009REFN ISSN 1097-2765PMID 20064473DOI 10.1016/J.MOLCEL.2009.11.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1nd7 WWP1 conformational flexibility underlies ubiquitin ligation mediated by the wwp1 hect domain e3 ligase 2.1Å AUTH M.A.VERDECIA,C.A.P.JOAZIERO,N.J.WELLS,J.-L.FERRER,AUTH 2 M.E.BOWMAN,T.HUNTER,J.P.NOELTITL CONFORMATIONAL FLEXIBILITY UNDERLIES UBIQUITINTITL 2 LIGATION MEDIATED BY THE WWP1 HECT DOMAIN E3 LIGASEREF MOL.CELL V. 11 249 2003REFN ISSN 1097-2765PMID 12535537DOI 10.1016/S1097-2765(02)00774-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3g1n HUWE1 catalytic domain of the human e3 ubiquitin-protein ligase huwe1 2.6Å AUTH J.R.WALKER,L.QIU,Y.LI,T.DAVIS,W.TEMPEL,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,AUTH 3 S.DHE-PAGANONTITL HECT DOMAIN OF HUMAN HUWE1/MULEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3sqv UBE2L3 crystal structure of e. coli o157:h7 e3 ubiquitin ligase, nlel, with a human e2, ubch7 3.3Å AUTH D.Y.LIN,J.DIAO,J.CHENTITL CRYSTAL STRUCTURES OF TWO BACTERIAL HECT-LIKE E3 LIGASES INTITL 2 COMPLEX WITH A HUMAN E2 REVEAL ATOMIC DETAILS OFTITL 3 PATHOGEN-HOST INTERACTIONS.REF PROC.NATL.ACAD.SCI.USA V. 109 1925 2012REFN ISSN 0027-8424PMID 22308380DOI 10.1073/PNAS.1115025109 Variant […]