Assessment of Structural Intolerance and Durability
General Structure Information 4gnk PLCB3 crystal structure of galphaq in complex with full-length human plcbeta3 4.0Å AUTH A.M.LYON,S.DUTTA,C.A.BOGUTH,G.SKINIOTIS,J.J.TESMERTITL FULL-LENGTH G ALPHA (Q)-PHOSPHOLIPASE C-BETA 3 STRUCTURETITL 2 REVEALS INTERFACES OF THE C-TERMINAL COILED-COIL DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 20 355 2013REFN ISSN 1545-9993PMID 23377541DOI 10.1038/NSMB.2497 Variant Set Distributions Mapped Variants
General Structure Information 4gnk PLCB3 crystal structure of galphaq in complex with full-length human plcbeta3 4.0Å AUTH A.M.LYON,S.DUTTA,C.A.BOGUTH,G.SKINIOTIS,J.J.TESMERTITL FULL-LENGTH G ALPHA (Q)-PHOSPHOLIPASE C-BETA 3 STRUCTURETITL 2 REVEALS INTERFACES OF THE C-TERMINAL COILED-COIL DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 20 355 2013REFN ISSN 1545-9993PMID 23377541DOI 10.1038/NSMB.2497 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2wz1 GUCY1B3 structure of the catalytic domain of human soluble guanylate cyclase 1 beta 3. 1.63Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ISSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Mapped Variants
General Structure Information 3kuc RAP1A complex of rap1a(e30d/k31e)gdp with rafrbd(a85k/n71r) 1.92Å AUTH D.FILCHTINSKI,O.SHARABI,A.RUPPEL,I.R.VETTER,C.HERRMANN,AUTH 2 J.M.SHIFMANTITL WHAT MAKES RAS AN EFFICIENT MOLECULAR SWITCH: ATITL 2 COMPUTATIONAL, BIOPHYSICAL, AND STRUCTURAL STUDY OF RAS-GDPTITL 3 INTERACTIONS WITH MUTANTS OF RAF.REF J.MOL.BIOL. V. 399 422 2010REFN ISSN 0022-2836PMID 20361980DOI 10.1016/J.JMB.2010.03.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2wz1 GUCY1B3 structure of the catalytic domain of human soluble guanylate cyclase 1 beta 3. 1.63Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ISSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Mapped Variants
General Structure Information 3kuc RAP1A complex of rap1a(e30d/k31e)gdp with rafrbd(a85k/n71r) 1.92Å AUTH D.FILCHTINSKI,O.SHARABI,A.RUPPEL,I.R.VETTER,C.HERRMANN,AUTH 2 J.M.SHIFMANTITL WHAT MAKES RAS AN EFFICIENT MOLECULAR SWITCH: ATITL 2 COMPUTATIONAL, BIOPHYSICAL, AND STRUCTURAL STUDY OF RAS-GDPTITL 3 INTERACTIONS WITH MUTANTS OF RAF.REF J.MOL.BIOL. V. 399 422 2010REFN ISSN 0022-2836PMID 20361980DOI 10.1016/J.JMB.2010.03.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2v55 RND3 mechanism of multi-site phosphorylation from a rock-i:rhoe complex structure 3.7Å AUTH D.KOMANDER,R.GARG,P.T.C.WAN,A.J.RIDLEY,D.BARFORDTITL MECHANISM OF MULTI-SITE PHOSPHORYLATION FROM ATITL 2 ROCK-I:RHOE COMPLEX STRUCTURE.REF EMBO J. V. 27 3175 2008REFN ISSN 0261-4189PMID 18946488DOI 10.1038/EMBOJ.2008.226 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2iu1 EIF5 crystal structure of eif5 c-terminal domain 1.8Å AUTH C.BIENIOSSEK,P.SCHUTZ,M.BUMANN,A.LIMACHER,I.USON,AUTH 2 U.BAUMANNTITL THE CRYSTAL STRUCTURE OF THE CARBOXY-TERMINALTITL 2 DOMAIN OF HUMAN TRANSLATION INITIATION FACTORTITL 3 EIF5.REF J.MOL.BIOL. V. 360 457 2006REFN ISSN 0022-2836PMID 16781736DOI 10.1016/J.JMB.2006.05.021 Variant Set Distributions Mapped Variants
General Structure Information 3e1y ETF1 crystal structure of human erf1/erf3 complex 3.8Å AUTH Z.CHENG,K.SAITO,A.V.PISAREV,M.WADA,V.P.PISAREVA,T.V.PESTOVA,AUTH 2 M.GAJDA,A.ROUND,C.KONG,M.LIM,Y.NAKAMURA,D.I.SVERGUN,K.ITO,AUTH 3 H.SONGTITL STRUCTURAL INSIGHTS INTO ERF3 AND STOP CODON RECOGNITION BYTITL 2 ERF1REF GENES DEV. V. 23 1106 2009REFN ISSN 0890-9369PMID 19417105DOI 10.1101/GAD.1770109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ds6 ARHGDIB crystal structure of a rac-rhogdi complex 2.35Å AUTH K.SCHEFFZEK,I.STEPHAN,O.N.JENSEN,D.ILLENBERGER,AUTH 2 P.GIERSCHIKTITL THE RAC-RHOGDI COMPLEX AND THE STRUCTURAL BASISTITL 2 FOR THE REGULATION OF RHO PROTEINS BY RHOGDI.REF NAT.STRUCT.BIOL. V. 7 122 2000REFN ISSN 1072-8368PMID 10655614DOI 10.1038/72392 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]