Assessment of Structural Intolerance and Durability
General Structure Information 1wer RASA1 ras-gtpase-activating domain of human p120gap 1.6Å AUTH K.SCHEFFZEK,A.LAUTWEIN,W.KABSCH,M.R.AHMADIAN,AUTH 2 A.WITTINGHOFERTITL CRYSTAL STRUCTURE OF THE GTPASE-ACTIVATING DOMAINTITL 2 OF HUMAN P120GAP AND IMPLICATIONS FOR THETITL 3 INTERACTION WITH RAS.REF NATURE V. 384 591 1996REFN ISSN 0028-0836PMID 8955277DOI 10.1038/384591A0 Variant Set Distributions Mapped Variants
General Structure Information 1nf1 NF1 the gap related domain of neurofibromin 2.5Å AUTH K.SCHEFFZEK,M.R.AHMADIAN,L.WIESMULLER,W.KABSCH,AUTH 2 P.STEGE,F.SCHMITZ,A.WITTINGHOFERTITL STRUCTURAL ANALYSIS OF THE GAP-RELATED DOMAIN FROMTITL 2 NEUROFIBROMIN AND ITS IMPLICATIONS.REF EMBO J. V. 17 4313 1998REFN ISSN 0261-4189PMID 9687500DOI 10.1093/EMBOJ/17.15.4313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mil SHC1 transforming protein 2.7Å AUTH V.MIKOL,G.BAUMANN,M.G.ZURINI,U.HOMMELTITL CRYSTAL STRUCTURE OF THE SH2 DOMAIN FROM THETITL 2 ADAPTOR PROTEIN SHC: A MODEL FOR PEPTIDE BINDINGTITL 3 BASED ON X-RAY AND NMR DATA.REF J.MOL.BIOL. V. 254 86 1995REFN ISSN 0022-2836PMID 7473762DOI 10.1006/JMBI.1995.0601 Variant Set Distributions Mapped Variants
General Structure Information 2vif SOCS6 crystal structure of socs6 sh2 domain in complex with a c-kit phosphopeptide 1.45Å AUTH F.ZADJALI,A.C.W.PIKE,M.VESTERLUND,J.SUN,C.WU,S.S.LI,AUTH 2 L.RONNSTRAND,S.KNAPP,A.BULLOCK,A.FLORES-MORALESTITL STRUCTURAL BASIS FOR C-KIT INHIBITION BY THETITL 2 SUPPRESSOR OF CYTOKINE SIGNALING 6 (SOCS6)TITL 3 UBIQUITIN LIGASE.REF J.BIOL.CHEM. V. 286 480 2011REFN ISSN 0021-9258PMID 21030588DOI 10.1074/JBC.M110.173526 Variant Set Distributions Mapped Variants