Assessment of Structural Intolerance and Durability
General Structure Information 2olm AGFG1 arfgap domain of hiv-1 rev binding protein 1.48Å AUTH Y.TONG,W.TEMPEL,L.SHEN,S.DIMOV,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARK,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL ARFGAP DOMAIN OF HIV-1 REV BINDING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hm8 HK3 crystal structure of the c-terminal hexokinase domain of human hk3 2.8Å AUTH L.NEDYALKOVA,Y.TONG,W.RABEH,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE C-TERMINAL HEXOKINASE DOMAIN OFTITL 2 HUMAN HK3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hlz KHK crystal structure of human ketohexokinase (casp target) 1.85Å AUTH W.M.RABEH,W.TEMPEL,L.NEDYALKOVA,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN KETOHEXOKINASE (CASPTITL 2 TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hle EFNB2 structural and biophysical characterization of the ephb4-ephrinb2 protein protein interaction and receptor specificity. 2.05Å AUTH J.E.CHRENCIK,A.BROOUN,M.L.KRAUS,M.I.RECHT,A.R.KOLATKAR,AUTH 2 G.W.HAN,J.M.SEIFERT,H.WIDMER,M.AUER,P.KUHNTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THETITL 2 EPHB4-EPHRINB2 PROTEIN-PROTEIN INTERACTION AND RECEPTORTITL 3 SPECIFICITY.REF J.BIOL.CHEM. V. 281 28185 2006REFN ISSN 0021-9258PMID 16867992DOI 10.1074/JBC.M605766200 Variant Set Distributions Mapped Variants
General Structure Information 2es0 RGS6 structure of the regulator of g-protein signaling domain of rgs6 2.1Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2h63 BLVRA crystal structure of human biliverdin reductase a (casp target) 2.7Å AUTH K.KAVANAGH,J.ELKINS,E.UGOCHUKWU,K.GUO,E.PILKA,AUTH 2 P.LUKACIK,C.SMEE,E.PAPAGRIGORIOU,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BILIVERDIN REDUCTASE AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ys2 BMX solution structure of the btk motif of human cytoplasmic tyrosine-protein kinase bmx -1.0Å AUTH H.ABE,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,M.YONEYAMA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BTK MOTIF OF HUMANTITL 2 CYTOPLASMIC TYROSINE-PROTEIN KINASE BMXREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2aw5 ME1 crystal structure of a human malic enzyme 2.5Å AUTH E.PAPAGRIGORIOU,G.BERRIDGE,C.SMEE,J.BRAY,AUTH 2 C.ARROWSMITH,A.EDWARDS,J.WEIGELT,M.SUNDSTROM,AUTH 3 U.OPPERMANN,O.GILEADI,F.VON DELFTTITL CRYSTAL STRUCTURE OF A HUMAN MALIC ENZYMEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dmw VAMP7 solution structure of the longin domain of synaptobrevin- like protein 1 -1.0Å AUTH S.OHNISHI,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE LONGIN DOMAIN OFTITL 2 SYNAPTOBREVIN-LIKE PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2do0 HNRNPM solution structure of the rna binding domain of heterogeneous nuclear ribonucleoprotein m -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA BINDING DOMAIN OFTITL 2 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN MREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants