Assessment of Structural Intolerance and Durability
General Structure Information 2epp PATZ1 solution structure of the first c2h2 type zinc finger domain of zinc finger protein 278 -1.0Å AUTH W.TANABE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2H2 TYPE ZINCTITL 2 FINGER DOMAIN OF ZINC FINGER PROTEIN 278REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gbj KIF13B crystal structure of the motor domain of kinesin kif13b bound with adp 2.1Å AUTH Y.TONG,L.SHEN,Y.SHEN,W.TEMPEL,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF KINESINTITL 2 KIF13B BOUND WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xsw INPP5E crystal structure of human inpp5e 1.9Å AUTH L.TRESAUGUES,P.SCHUTZ,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WELIN,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN INPP5EREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2crf RANBP3 solution structure of the ran_bp1 domain of ran-binding protein-3 -1.0Å AUTH H.P.ZHANG,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RAN_BP1 DOMAIN OFTITL 2 RAN-BINDING PROTEIN-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gao SAR1A crystal structure of human sar1a in complex with gdp 2.0Å AUTH J.WANG,S.DIMOV,W.TEMPEL,D.YANIW,C.ARROWSMITH,AUTH 2 A.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN SAR1A IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2q3f RRAGD x-ray crystal structure of putative human ras-related gtp binding d in complex with gmppnp 2.1Å AUTH A.M.MULICHAK,W.M.RABEH,W.TEMPEL,L.NEDYALKOVA,AUTH 2 R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,AUTH 3 J.WEIGELT,L.J.KEEFE,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAS-RELATED GTP-BINDINGTITL 2 D.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2r55 STARD5 human star-related lipid transfer protein 5 2.5Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Mapped Variants
General Structure Information 4hfg RPRD1B cid of human rprd1b 2.0Å AUTH Z.NI,C.XU,W.TEMPEL,M.EL BAKKOURI,P.LOPPNAU,X.GUO,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,J.F.GREENBLATTTITL CID OF HUMAN RPRD1BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fla RPRD1B crystal structure of human rprd1b, carboxy-terminal domain 2.2Å AUTH Z.NI,C.XU,X.GUO,G.O.HUNTER,O.V.KUZNETSOVA,W.TEMPEL,E.MARCON,AUTH 2 G.ZHONG,H.GUO,W.H.KUO,J.LI,P.YOUNG,J.B.OLSEN,C.WAN,AUTH 3 P.LOPPNAU,M.EL BAKKOURI,G.A.SENISTERRA,H.HE,H.HUANG,AUTH 4 S.S.SIDHU,A.EMILI,S.MURPHY,A.L.MOSLEY,C.H.ARROWSMITH,J.MIN,AUTH 5 J.F.GREENBLATTTITL RPRD1A AND RPRD1B ARE HUMAN RNA POLYMERASE II C-TERMINALTITL 2 DOMAIN SCAFFOLDS FOR SER5 DEPHOSPHORYLATION.REF NAT.STRUCT.MOL.BIOL. V. 21 686 2014REFN ISSN 1545-9993PMID 24997600DOI 10.1038/NSMB.2853 Variant Set Distributions Mapped Variants
General Structure Information 4e74 PLXNA4 crystal structure of the rho gtpase binding domain of plexin a4a 1.58Å AUTH X.GUAN,H.WANG,W.TEMPEL,A.DONG,Y.TONG,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF PLEXINTITL 2 A4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants