Assessment of Structural Intolerance and Durability
General Structure Information 3ega PELI2 crystal structure of pellino2 fha domain at 1.8 angstroms resolution 1.8Å AUTH C.C.LIN,Y.S.HUOH,K.R.SCHMITZ,L.E.JENSEN,K.M.FERGUSONTITL PELLINO PROTEINS CONTAIN A CRYPTIC FHA DOMAIN THAT MEDIATESTITL 2 INTERACTION WITH PHOSPHORYLATED IRAK1.REF STRUCTURE V. 16 1806 2008REFN ISSN 0969-2126PMID 19081057DOI 10.1016/J.STR.2008.09.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4h87 SLC4A1AP crystal structure of a fha domain of kanadaptin (slc4a1ap) from homo sapiens at 1.55 a resolution 1.55Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)TITL CRYSTAL STRUCTURE OF A FHA DOMAIN OF KANADAPTIN (SLC4A1AP)TITL 2 FROM HOMO SAPIENS AT 1.55 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1lgq CHFR crystal structure of the fha domain of the chfr mitotic checkpoint protein 2.1Å AUTH E.S.STAVRIDI,Y.HUYEN,I.R.LORETO,D.M.SCOLNICK,AUTH 2 T.D.HALAZONETIS,N.P.PAVLETICH,P.D.JEFFREYTITL CRYSTAL STRUCTURE OF THE FHA DOMAIN OF THE CHFRTITL 2 MITOTIC CHECKPOINT PROTEIN AND ITS COMPLEX WITHTITL 3 TUNGSTATE.REF STRUCTURE V. 10 891 2002REFN ISSN 0969-2126PMID 12121644DOI 10.1016/S0969-2126(02)00776-1 Variant Set Distributions Mapped Variants
General Structure Information 3kt9 APTX aprataxin fha domain 1.65Å AUTH O.J.BECHEREL,B.JAKOB,A.L.CHERRY,N.GUEVEN,M.FUSSER,AUTH 2 A.W.KIJAS,C.PENG,S.KATYAL,P.J.MCKINNON,J.CHEN,AUTH 3 B.EPE,S.J.SMERDON,G.TAUCHER-SCHOLZ,M.F.LAVINTITL CK2 PHOSPHORYLATION-DEPENDENT INTERACTION BETWEENTITL 2 APRATAXIN AND MDC1 IN THE DNA DAMAGE RESPONSE.REF NUCLEIC ACIDS RES. V. 38 1489 2010REFN ISSN 0305-1048PMID 20008512DOI 10.1093/NAR/GKP1149 Variant Set Distributions Mapped Variants
General Structure Information 4jon CEP170 crystal structure of a centrosomal protein 170kda, transcript variant beta (cep170) from homo sapiens at 2.15 a resolution (psi community target, sundstrom) 2.15Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)TITL CRYSTAL STRUCTURE OF A CENTROSOMAL PROTEIN 170KDA,TITL 2 TRANSCRIPT VARIANT BETA (CEP170) FROM HOMO SAPIENS AT 2.15 ATITL 3 RESOLUTION […]
General Structure Information 3uot MDC1 crystal structure of mdc1 fha domain in complex with a phosphorylated peptide from the mdc1 n-terminus 1.8Å AUTH S.JUNGMICHEL,J.A.CLAPPERTON,J.LLOYD,F.J.HARI,C.SPYCHER,AUTH 2 L.PAVIC,J.LI,L.F.HAIRE,M.BONALLI,D.H.LARSEN,C.LUKAS,J.LUKAS,AUTH 3 D.MACMILLAN,M.L.NIELSEN,M.STUCKI,S.J.SMERDONTITL THE MOLECULAR BASIS OF ATM-DEPENDENT DIMERIZATION OF THETITL 2 MDC1 DNA DAMAGE CHECKPOINT MEDIATOR.REF NUCLEIC ACIDS RES. V. 40 3913 2012REFN ISSN 0305-1048PMID 22234878DOI 10.1093/NAR/GKR1300 Variant Set […]
General Structure Information 3uot MDC1 crystal structure of mdc1 fha domain in complex with a phosphorylated peptide from the mdc1 n-terminus 1.8Å AUTH S.JUNGMICHEL,J.A.CLAPPERTON,J.LLOYD,F.J.HARI,C.SPYCHER,AUTH 2 L.PAVIC,J.LI,L.F.HAIRE,M.BONALLI,D.H.LARSEN,C.LUKAS,J.LUKAS,AUTH 3 D.MACMILLAN,M.L.NIELSEN,M.STUCKI,S.J.SMERDONTITL THE MOLECULAR BASIS OF ATM-DEPENDENT DIMERIZATION OF THETITL 2 MDC1 DNA DAMAGE CHECKPOINT MEDIATOR.REF NUCLEIC ACIDS RES. V. 40 3913 2012REFN ISSN 0305-1048PMID 22234878DOI 10.1093/NAR/GKR1300 Variant Set […]
General Structure Information 3uot MDC1 crystal structure of mdc1 fha domain in complex with a phosphorylated peptide from the mdc1 n-terminus 1.8Å AUTH S.JUNGMICHEL,J.A.CLAPPERTON,J.LLOYD,F.J.HARI,C.SPYCHER,AUTH 2 L.PAVIC,J.LI,L.F.HAIRE,M.BONALLI,D.H.LARSEN,C.LUKAS,J.LUKAS,AUTH 3 D.MACMILLAN,M.L.NIELSEN,M.STUCKI,S.J.SMERDONTITL THE MOLECULAR BASIS OF ATM-DEPENDENT DIMERIZATION OF THETITL 2 MDC1 DNA DAMAGE CHECKPOINT MEDIATOR.REF NUCLEIC ACIDS RES. V. 40 3913 2012REFN ISSN 0305-1048PMID 22234878DOI 10.1093/NAR/GKR1300 Variant Set […]
General Structure Information 4egx KIF1A crystal structure of kif1a cc1-fha tandem 2.51Å AUTH L.HUO,Y.YUE,J.REN,J.YU,J.LIU,Y.YU,F.YE,T.XU,M.ZHANG,W.FENGTITL THE CC1-FHA TANDEM AS A CENTRAL HUB FOR CONTROLLING THETITL 2 DIMERIZATION AND ACTIVATION OF KINESIN-3 KIF1AREF STRUCTURE V. 20 1550 2012REFN ISSN 0969-2126PMID 22863567DOI 10.1016/J.STR.2012.07.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4egx KIF1A crystal structure of kif1a cc1-fha tandem 2.51Å AUTH L.HUO,Y.YUE,J.REN,J.YU,J.LIU,Y.YU,F.YE,T.XU,M.ZHANG,W.FENGTITL THE CC1-FHA TANDEM AS A CENTRAL HUB FOR CONTROLLING THETITL 2 DIMERIZATION AND ACTIVATION OF KINESIN-3 KIF1AREF STRUCTURE V. 20 1550 2012REFN ISSN 0969-2126PMID 22863567DOI 10.1016/J.STR.2012.07.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants