Assessment of Structural Intolerance and Durability
General Structure Information 2gw6 TSEN15 nmr structure of the human trna endonuclease sen15 subunit -1.0Å AUTH J.SONG,J.L.MARKLEYTITL THREE-DIMENSIONAL STRUCTURE DETERMINED FOR ATITL 2 SUBUNIT OF HUMAN TRNA SPLICING ENDONUCLEASETITL 3 (SEN15) REVEALS A NOVEL DIMERIC FOLD.REF J.MOL.BIOL. V. 366 155 2007REFN ISSN 0022-2836PMID 17166513DOI 10.1016/J.JMB.2006.11.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3c9q WDYHV1 crystal structure of the uncharacterized human protein c8orf32 with bound peptide 1.5Å AUTH E.BITTO,C.A.BINGMAN,J.G.MCCOY,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF THE UNCHARACTERIZED HUMAN PROTEINTITL 2 C8ORF32 WITH BOUND PEPTIDE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2bei SAT2 x-ray structure of thialysine n-acetyltransferase (ssat2) from homo sapiens 1.84Å AUTH B.W.HAN,C.A.BINGMAN,G.E.WESENBERG,G.N.PHILLIPSTITL CRYSTAL STRUCTURE OF HOMO SAPIENS THIALYSINETITL 2 NEPSILON-ACETYLTRANSFERASE (HSSSAT2) IN COMPLEXTITL 3 WITH ACETYL COENZYME A.REF PROTEINS V. 64 288 2006REFN ISSN 0887-3585PMID 16596569DOI 10.1002/PROT.20967 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kom PARD3 solution structure of humar par-3b pdz2 (residues 451-549) -1.0Å AUTH D.R.JENSEN,C.WOYTOVICH,M.LI,P.DUVNJAK,M.S.CASSIDY,AUTH 2 R.O.FREDERICK,L.F.BERGEMAN,F.C.PETERSON,B.F.VOLKMANTITL RAPID, ROBOTIC, SMALL-SCALE PROTEIN PRODUCTION FORTITL 2 NMR SCREENING AND STRUCTURE DETERMINATION.REF PROTEIN SCI. V. 19 570 2010REFN ISSN 0961-8368PMID 20073081DOI 10.1002/PRO.335 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bvo HSCB crystal structure of human co-chaperone protein hscb 3.0Å AUTH E.BITTO,C.A.BINGMAN,L.BITTOVA,D.A.KONDRASHOV,R.M.BANNEN,AUTH 2 B.G.FOX,J.L.MARKLEY,G.N.PHILLIPSTITL STRUCTURE OF HUMAN J-TYPE CO-CHAPERONE HSCB REVEALS ATITL 2 TETRACYSTEINE METAL-BINDING DOMAIN.REF J.BIOL.CHEM. V. 283 30184 2008REFN ISSN 0021-9258PMID 18713742DOI 10.1074/JBC.M804746200 Variant Set Distributions Mapped Variants
General Structure Information 3ecs EIF2B1 crystal structure of human eif2b alpha 2.65Å AUTH T.B.HIYAMA,T.ITO,H.IMATAKA,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF HUMAN TRANSLATIONTITL 2 INITIATION FACTOR 2BREF J.MOL.BIOL. V. 392 937 2009REFN ISSN 0022-2836PMID 19631657DOI 10.1016/J.JMB.2009.07.054 Variant Set Distributions Mapped Variants
General Structure Information 2qnd FMR1 crystal structure of the kh1-kh2 domains from human fragile x mental retardation protein 1.9Å AUTH R.VALVERDE,I.POZDNYAKOVA,T.KAJANDER,J.VENKATRAMAN,L.REGANTITL FRAGILE X MENTAL RETARDATION SYNDROME: STRUCTURE OF THETITL 2 KH1-KH2 DOMAINS OF FRAGILE X MENTAL RETARDATION PROTEIN.REF STRUCTURE V. 15 1090 2007REFN ISSN 0969-2126PMID 17850748DOI 10.1016/J.STR.2007.06.022 Variant Set Distributions Mapped Variants
General Structure Information 2nlw EIF3B solution structure of the rrm domain of human eukaryotic initiation factor 3b -1.0Å AUTH L.ELANTAK,A.G.TZAKOS,N.LOCKER,P.J.LUKAVSKYTITL STRUCTURE OF EIF3B RNA RECOGNITION MOTIF AND ITSTITL 2 INTERACTION WITH EIF3J: STRUCTURAL INSIGHTS INTOTITL 3 THE RECRUITMENT OF EIF3B TO THE 40 S RIBOSOMALTITL 4 SUBUNIT.REF J.BIOL.CHEM. V. 282 8165 2007REFN ISSN 0021-9258PMID 17190833DOI […]
General Structure Information 3u9c CSNK2A1 structure of a c-terminal deletion mutant of human protein kinase ck2 catalytic subunit with the atp-competitive inhibitor resorufin 3.2Å AUTH K.KLOPFFLEISCH,O.G.ISSINGER,K.NIEFINDTITL LOW-DENSITY CRYSTAL PACKING OF HUMAN PROTEIN KINASE CK2TITL 2 CATALYTIC SUBUNIT IN COMPLEX WITH RESORUFIN OR OTHERTITL 3 LIGANDS: A TOOL TO STUDY THE UNIQUE HINGE-REGION PLASTICITYTITL 4 OF […]
General Structure Information 2qnd FMR1 crystal structure of the kh1-kh2 domains from human fragile x mental retardation protein 1.9Å AUTH R.VALVERDE,I.POZDNYAKOVA,T.KAJANDER,J.VENKATRAMAN,L.REGANTITL FRAGILE X MENTAL RETARDATION SYNDROME: STRUCTURE OF THETITL 2 KH1-KH2 DOMAINS OF FRAGILE X MENTAL RETARDATION PROTEIN.REF STRUCTURE V. 15 1090 2007REFN ISSN 0969-2126PMID 17850748DOI 10.1016/J.STR.2007.06.022 Variant Set Distributions Mapped Variants