Assessment of Structural Intolerance and Durability
General Structure Information 4i6x PDIA5 crystal structure of non-catalyic domain of protein disulfide isomerase-related (pdir) protein 1.5Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL STRUCTURE OF THE NON-CATALYTIC DOMAIN OF THE PROTEINTITL 2 DISULFIDE ISOMERASE-RELATED PROTEIN (PDIR) REVEALS FUNCTIONTITL 3 IN PROTEIN BINDING.REF PLOS ONE V. 8 62021 2013REFN ESSN 1932-6203PMID 23614004DOI 10.1371/JOURNAL.PONE.0062021 Variant Set Distributions Mapped Variants
General Structure Information 4gwr PDIA6 crystal structure of the second catalytic domain of protein disulfide isomerase p5 1.81Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL TO BE PUBLISHEDREF TO BE PUBLISHED 2013REFN Variant Set Distributions Mapped Variants
General Structure Information 4gwr PDIA6 crystal structure of the second catalytic domain of protein disulfide isomerase p5 1.81Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL TO BE PUBLISHEDREF TO BE PUBLISHED 2013REFN Variant Set Distributions Mapped Variants
General Structure Information 4gwr PDIA6 crystal structure of the second catalytic domain of protein disulfide isomerase p5 1.81Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL TO BE PUBLISHEDREF TO BE PUBLISHED 2013REFN Variant Set Distributions Mapped Variants
General Structure Information 2kij ATP7A solution structure of the actuator domain of the copper- transporting atpase atp7a -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,M.MIGLIARDI,G.NATILE,AUTH 2 F.NUSHI,A.ROSATOTITL SOLUTION STRUCTURES OF THE ACTUATOR DOMAIN OF ATP7ATITL 2 AND ATP7B, THE MENKES AND WILSON DISEASE PROTEINSREF BIOCHEMISTRY V. 48 7849 2009REFN ISSN 0006-2960PMID 19645496DOI 10.1021/BI901003K Variant Set Distributions Mapped Variants
General Structure Information 2kmv ATP7A solution structure of the nucleotide binding domain of the human menkes protein in the atp-free form -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,S.INAGAKI,M.MIGLIARDI,AUTH 2 A.ROSATOTITL THE BINDING MODE OF ATP REVEALED BY THE SOLUTIONTITL 2 STRUCTURE OF THE N-DOMAIN OF HUMAN ATP7A.REF J.BIOL.CHEM. 2009REFN ESSN 1083-351XPMID 19917612DOI 10.1074/JBC.M109.054262 Variant Set Distributions Mapped Variants
General Structure Information 2y4t DNAJC3 crystal structure of the human co-chaperone p58(ipk) 3.0Å AUTH M.SVARD,E.I.BITEROVA,J.-M.BOURHIS,J.E.GUYTITL THE CRYSTAL STRUCTURE OF THE HUMAN CO-CHAPERONE P58IPKREF PLOS ONE V. 6 22337 2011REFN ISSN 1932-6203PMID 21799829DOI 10.1371/JOURNAL.PONE.0022337 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f8u TAPBP tapasin/erp57 heterodimer 2.6Å AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f8u TAPBP tapasin/erp57 heterodimer 2.6Å AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kmv ATP7A solution structure of the nucleotide binding domain of the human menkes protein in the atp-free form -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,S.INAGAKI,M.MIGLIARDI,AUTH 2 A.ROSATOTITL THE BINDING MODE OF ATP REVEALED BY THE SOLUTIONTITL 2 STRUCTURE OF THE N-DOMAIN OF HUMAN ATP7A.REF J.BIOL.CHEM. 2009REFN ESSN 1083-351XPMID 19917612DOI 10.1074/JBC.M109.054262 Variant Set Distributions Mapped Variants