Assessment of Structural Intolerance and Durability
General Structure Information 4ckr DDR1 crystal structure of the human ddr1 kinase domain in complex with ddr1-in-1 2.2Å AUTH H.KIM,L.TAN,E.L.WEISBERG,F.LIU,P.CANNING,H.G.CHOI,S.A.EZELL,AUTH 2 H.WU,Z.ZHAO,J.WANG,A.MANDINOVA,J.D.GRIFFIN,A.N.BULLOCK,AUTH 3 Q.LIU,S.W.LEE,N.S.GRAYTITL DISCOVERY OF A POTENT AND SELECTIVE DDR1 RECEPTOR TYROSINETITL 2 KINASE INHIBITOR.REF ACS CHEM.BIOL. V. 8 2145 2013REFN ISSN 1554-8929PMID 23899692DOI 10.1021/CB400430T Variant Set Distributions Mapped Variants
General Structure Information 1gzh TP53BP1 crystal structure of the brct domains of human 53bp1 bound to the p53 tumor supressor 2.6Å AUTH D.J.DERBYSHIRE,B.P.BASU,L.SERPELL,W.JOO,T.DATE,AUTH 2 K.IWABUCHI,A.J.DOHERTYTITL CRYSTAL STRUCTURE OF HUMAN 53BP1 BRCT DOMAINSTITL 2 BOUND TO P53 TUMOUR SUPPRESSORREF EMBO J. V. 21 3863 2002REFN ISSN 0261-4189PMID 12110597DOI 10.1093/EMBOJ/CDF383 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3cyy TJP1 the crystal structure of zo-1 pdz2 in complex with the cx43 peptide 2.4Å AUTH J.CHEN,L.PAN,Z.WEI,Y.ZHAO,M.ZHANGTITL DOMAIN-SWAPPED DIMERIZATION OF ZO-1 PDZ2 GENERATES SPECIFICTITL 2 AND REGULATORY CONNEXIN43-BINDING SITESREF EMBO J. V. 27 2113 2008REFN ISSN 0261-4189PMID 18636092DOI 10.1038/EMBOJ.2008.138 Variant Set Distributions Mapped Variants
General Structure Information 1jj7 TAP1 crystal structure of the c-terminal atpase domain of human tap1 2.4Å AUTH R.GAUDET,D.C.WILEYTITL STRUCTURE OF THE ABC ATPASE DOMAIN OF HUMAN TAP1,TITL 2 THE TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING.REF EMBO J. V. 20 4964 2001REFN ISSN 0261-4189PMID 11532960DOI 10.1093/EMBOJ/20.17.4964 Variant Set Distributions Mapped Variants
General Structure Information 4n0f FCGRT human fcrn complexed with human serum albumin 3.02Å AUTH V.OGANESYAN,M.M.DAMSCHRODER,K.E.COOK,Q.LI,C.GAO,H.WU,AUTH 2 W.F.DALLACQUATITL STRUCTURAL INSIGHTS INTO NEONATAL FC RECEPTOR-BASEDTITL 2 RECYCLING MECHANISMS.REF J.BIOL.CHEM. V. 289 7812 2014REFN ISSN 0021-9258PMID 24469444DOI 10.1074/JBC.M113.537563 Variant Set Distributions Mapped Variants
General Structure Information 1pbk FKBP3 homologous domain of human fkbp25 2.5Å AUTH J.LIANG,D.T.HUNG,S.L.SCHREIBER,J.CLARDYTITL STRUCTURE OF THE HUMAN 25 KDA FK506 BINDINGTITL 2 PROTEIN COMPLEXED WITH RAPAMYCIN.REF J.AM.CHEM.SOC. V. 118 1231 1996REFN ISSN 0002-7863 Variant Set Distributions Mapped Variants
General Structure Information 2yuz MYBPC1 solution structure of 4th immunoglobulin domain of slow type myosin-binding protein c -1.0Å AUTH T.N.NIRAULA,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF 4TH IMMUNOGLOBULIN DOMAIN OFTITL 2 SLOW TYPE MYOSIN-BINDING PROTEIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dtc MAP3K9 crystal structure of mixed-lineage kinase mlk1 complexed with compound 16 2.6Å AUTH R.L.HUDKINS,J.L.DIEBOLD,M.TAO,K.A.JOSEF,C.H.PARK,AUTH 2 T.S.ANGELES,L.D.AIMONE,J.HUSTEN,M.A.ATOR,S.L.MEYER,AUTH 3 B.P.HOLSKIN,J.T.DURKIN,A.A.FEDOROV,E.V.FEDOROV,AUTH 4 S.C.ALMO,J.R.MATHIASEN,D.BOZYCZKO-COYNE,AUTH 5 M.S.SAPORITO,R.W.SCOTT,J.P.MALLAMOTITL MIXED-LINEAGE KINASE 1 AND MIXED-LINEAGE KINASE 3TITL 2 SUBTYPE-SELECTIVETITL 3 DIHYDRONAPHTHYL[3,4-A]PYRROLO[3,4-C]CARBAZOLE-5-TITL 4 ONES: OPTIMIZATION, MIXED-LINEAGE KINASE 1TITL 5 CRYSTALLOGRAPHY, AND ORAL IN VIVO ACTIVITY INTITL 6 1-METHYL-4-PHENYLTETRAHYDROPYRIDINE MODELS.REF J.MED.CHEM. […]
General Structure Information 3l6a EIF4G2 crystal structure of the c-terminal region of human p97 2.0Å AUTH S.FAN,M.JIA,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF HUMANTITL 2 P97/DAP5REF PROTEINS 2010REFN ESSN 1097-0134DOI 10.1002/PROT.22735 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4js0 CDC42 complex of cdc42 with the crib-pr domain of irsp53 1.9Å AUTH D.J.KAST,C.YANG,A.DISANZA,M.BOCZKOWSKA,Y.MADASU,G.SCITA,AUTH 2 T.SVITKINA,R.DOMINGUEZTITL MECHANISM OF IRSP53 INHIBITION AND COMBINATORIAL ACTIVATIONTITL 2 BY CDC42 AND DOWNSTREAM EFFECTORS.REF NAT.STRUCT.MOL.BIOL. V. 21 413 2014REFN ISSN 1545-9993PMID 24584464DOI 10.1038/NSMB.2781 Variant Set Distributions Mapped Variants