Assessment of Structural Intolerance and Durability
General Structure Information 4k2p TIAM1 the structure of a quintuple mutant of the tiam1 ph-cc-ex domain 1.98Å AUTH M.JOSHI,L.GAKHAR,E.J.FUENTESTITL HIGH-RESOLUTION STRUCTURE OF THE TIAM1 PHN-CC-EX DOMAIN.REF ACTA CRYSTALLOGR.,SECT.F V. 69 744 2013REFN ESSN 1744-3091PMID 23832200DOI 10.1107/S1744309113014206 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hk0 GRB10 crystal structure of the ra and ph domains of grb10 2.6Å AUTH R.S.DEPETRIS,J.WU,S.R.HUBBARDTITL STRUCTURAL AND FUNCTIONAL STUDIES OF THE RAS-ASSOCIATING ANDTITL 2 PLECKSTRIN-HOMOLOGY DOMAINS OF GRB10 AND GRB14.REF NAT.STRUCT.MOL.BIOL. V. 16 833 2009REFN ISSN 1545-9993PMID 19648926DOI 10.1038/NSMB.1642 Variant Set Distributions Mapped Variants
General Structure Information 3coa FOXO1 crystal structure of foxo1 dbd bound to ire dna 2.2Å AUTH M.M.BRENT,R.ANAND,R.MARMORSTEINTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY FOXO1 ANDTITL 2 ITS REGULATION BY POSTTRANSLATIONAL MODIFICATION.REF STRUCTURE V. 16 1407 2008REFN ISSN 0969-2126PMID 18786403DOI 10.1016/J.STR.2008.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4egx KIF1A crystal structure of kif1a cc1-fha tandem 2.51Å AUTH L.HUO,Y.YUE,J.REN,J.YU,J.LIU,Y.YU,F.YE,T.XU,M.ZHANG,W.FENGTITL THE CC1-FHA TANDEM AS A CENTRAL HUB FOR CONTROLLING THETITL 2 DIMERIZATION AND ACTIVATION OF KINESIN-3 KIF1AREF STRUCTURE V. 20 1550 2012REFN ISSN 0969-2126PMID 22863567DOI 10.1016/J.STR.2012.07.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 2oo4 NOTCH2 structure of lnr-hd (negative regulatory region) from human notch 2 2.0Å AUTH W.R.GORDON,D.VARDAR-ULU,G.HISTEN,C.SANCHEZ-IRIZARRY,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURAL BASIS FOR AUTOINHIBITION OF NOTCHREF NAT.STRUCT.MOL.BIOL. V. 14 295 2007REFN ISSN 1545-9993PMID 17401372DOI 10.1038/NSMB1227 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yse SATB1 solution structure of the mar-binding domain of satb1 -1.0Å AUTH H.YAMAGUCHI,M.TATENO,K.YAMASAKITITL SOLUTION STRUCTURE AND DNA-BINDING MODE OF THETITL 2 MATRIX ATTACHMENT REGION-BINDING DOMAIN OF THETITL 3 TRANSCRIPTION FACTOR SATB1 THAT REGULATES THETITL 4 T-CELL MATURATIONREF J.BIOL.CHEM. V. 281 5319 2006REFN ISSN 0021-9258PMID 16371359DOI 10.1074/JBC.M510933200 Variant Set Distributions Mapped Variants