Assessment of Structural Intolerance and Durability
General Structure Information 4gnk PLCB3 crystal structure of galphaq in complex with full-length human plcbeta3 4.0Å AUTH A.M.LYON,S.DUTTA,C.A.BOGUTH,G.SKINIOTIS,J.J.TESMERTITL FULL-LENGTH G ALPHA (Q)-PHOSPHOLIPASE C-BETA 3 STRUCTURETITL 2 REVEALS INTERFACES OF THE C-TERMINAL COILED-COIL DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 20 355 2013REFN ISSN 1545-9993PMID 23377541DOI 10.1038/NSMB.2497 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1k78 PAX5 pax5(1-149)+ets-1(331-440)+dna 2.25Å AUTH C.W.GARVIE,J.HAGMAN,C.WOLBERGERTITL STRUCTURAL STUDIES OF ETS-1/PAX5 COMPLEX FORMATIONTITL 2 ON DNA.REF MOL.CELL V. 8 1267 2001REFN ISSN 1097-2765PMID 11779502DOI 10.1016/S1097-2765(01)00410-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l5k HDHD1 the crystal structure of human haloacid dehalogenase-like hydrolase domain containing 1a (hdhd1a) 2.0Å AUTH E.UGOCHUKWU,K.GUO,S.PICAUD,J.MUNIZ,C.ALLERSTON,AUTH 2 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,W.W.YUE,K.L.KAVANAGH,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF HUMAN HALOACIDTITL 2 DEHALOGENASE-LIKE HYDROLASE DOMAIN CONTAINING 1ATITL 3 (HDHD1A)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3l5k HDHD1 the crystal structure of human haloacid dehalogenase-like hydrolase domain containing 1a (hdhd1a) 2.0Å AUTH E.UGOCHUKWU,K.GUO,S.PICAUD,J.MUNIZ,C.ALLERSTON,AUTH 2 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,W.W.YUE,K.L.KAVANAGH,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF HUMAN HALOACIDTITL 2 DEHALOGENASE-LIKE HYDROLASE DOMAIN CONTAINING 1ATITL 3 (HDHD1A)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3l5k HDHD1 the crystal structure of human haloacid dehalogenase-like hydrolase domain containing 1a (hdhd1a) 2.0Å AUTH E.UGOCHUKWU,K.GUO,S.PICAUD,J.MUNIZ,C.ALLERSTON,AUTH 2 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,W.W.YUE,K.L.KAVANAGH,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF HUMAN HALOACIDTITL 2 DEHALOGENASE-LIKE HYDROLASE DOMAIN CONTAINING 1ATITL 3 (HDHD1A)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2cqi TIAL1 solution structure of the rna binding domain of nucleolysin tiar -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,M.SHIROUZU,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA BINDING DOMAIN OF NUCLEOLYSINTITL 2 TIARREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4azm FABP5 human epidermal fatty acid-binding protein (fabp5) in complex with the inhibitor bms-309413 2.75Å AUTH B.SANSON,T.WANG,J.SUN,L.WANG,M.KACZOCHA,I.OJIMA,D.DEUTSCH,AUTH 2 H.LITITL CRYSTALLOGRAPHIC STUDY OF FABP5 AS AN INTRACELLULARTITL 2 ENDOCANNABINOID TRANSPORTER.REF ACTA CRYSTALLOGR.,SECT.D V. 70 290 2014REFN ISSN 0907-4449PMID 24531463DOI 10.1107/S1399004713026795 Variant Set Distributions Mapped Variants
General Structure Information 3g73 FOXM1 structure of the foxm1 dna binding 2.21Å AUTH D.R.LITTLER,M.ALVAREZ-FERNANDEZ,A.STEIN,R.G.HIBBERT,AUTH 2 T.HEIDEBRECHT,P.ALOY,R.H.MEDEMA,A.PERRAKISTITL STRUCTURE OF THE FOXM1 DNA-RECOGNITION DOMAIN BOUND TO ATITL 2 PROMOTER SEQUENCEREF NUCLEIC ACIDS RES. 2010REFN ESSN 1362-4962PMID 20360045DOI 10.1093/NAR/GKQ194 Variant Set Distributions Mapped Variants
General Structure Information 4bkx MTA1 the structure of hdac1 in complex with the dimeric elm2-sant domain of mta1 from the nurd complex 3.0Å AUTH C.J.MILLARD,P.J.WATSON,I.CELARDO,Y.GORDIYENKO,S.M.COWLEY,AUTH 2 C.V.ROBINSON,L.FAIRALL,J.W.R.SCHWABETITL CLASS I HDACS SHARE A COMMON MECHANISM OF REGULATION BYTITL 2 INOSITOL PHOSPHATES.REF MOL.CELL V. 51 57 2013REFN ISSN 1097-2765PMID 23791785DOI 10.1016/J.MOLCEL.2013.05.020 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1aqc APBA1 x11 ptb domain-10mer peptide complex 2.3Å AUTH Z.ZHANG,C.H.LEE,V.MANDIYAN,J.P.BORG,B.MARGOLIS,AUTH 2 J.SCHLESSINGER,J.KURIYANTITL SEQUENCE-SPECIFIC RECOGNITION OF THETITL 2 INTERNALIZATION MOTIF OF THE ALZHEIMERS AMYLOIDTITL 3 PRECURSOR PROTEIN BY THE X11 PTB DOMAIN.REF EMBO J. V. 16 6141 1997REFN ISSN 0261-4189PMID 9321393DOI 10.1093/EMBOJ/16.20.6141 Variant Set Distributions Mapped Variants