Assessment of Structural Intolerance and Durability
General Structure Information 1joc EEA1 eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate 2.2Å AUTH J.J.DUMAS,E.MERITHEW,E.SUDHARSHAN,D.RAJAMANI,AUTH 2 S.HAYES,D.LAWE,S.CORVERA,D.G.LAMBRIGHTTITL MULTIVALENT ENDOSOME TARGETING BY HOMODIMERIC EEA1.REF MOL.CELL V. 8 947 2001REFN ISSN 1097-2765PMID 11741531DOI 10.1016/S1097-2765(01)00385-9 Variant Set Distributions Mapped Variants
General Structure Information 2d7m FLNC solution structure of the 14th filamin domain from human filamin c -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 14TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qms GRB7 crystal structure of a signaling molecule 2.1Å AUTH C.J.PORTER,J.M.MATTHEWS,J.P.MACKAY,S.E.PURSGLOVE,AUTH 2 J.W.SCHMIDBERGER,P.J.LEEDMAN,S.C.PERO,D.N.KRAG,AUTH 3 M.C.WILCE,J.A.WILCETITL GRB7 SH2 DOMAIN STRUCTURE AND INTERACTIONS WITH ATITL 2 CYCLIC PEPTIDE INHIBITOR OF CANCER CELL MIGRATIONTITL 3 AND PROLIFERATION.REF BMC STRUCT.BIOL. V. 7 58 2007REFN ESSN 1472-6807PMID 17894853DOI 10.1186/1472-6807-7-58 Variant Set Distributions Mapped Variants
General Structure Information 2dll IRF4 solution structure of the irf domain of human interferon regulator factors 4 -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IRF DOMAIN OF HUMANTITL 2 INTERFERON REGULATOR FACTORS 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kgt PTK6 solution structure of sh3 domain of ptk6 -1.0Å AUTH W.LEE,S.KOTITL THE SOLUTION STRUCTURE OF SH3 DOMAIN OF PTK6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1y7q ZNF174 mammalian scan domain dimer is a domain-swapped homologue of the hiv capsid c-terminal domain -1.0Å AUTH D.IVANOV,J.R.STONE,J.L.MAKI,T.COLLINS,G.WAGNERTITL MAMMALIAN SCAN DOMAIN DIMER IS A DOMAIN-SWAPPEDTITL 2 HOMOLOG OF THE HIV CAPSID C-TERMINAL DOMAINREF MOL.CELL V. 17 137 2005REFN ISSN 1097-2765PMID 15629724DOI 10.1016/J.MOLCEL.2004.12.015 Variant Set Distributions Mapped Variants
General Structure Information 1wi5 PDCD11 solution structure of the s1 rna binding domain from human hypothetical protein baa11502 -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE S1 RNA BINDING DOMAINTITL 2 FROM HUMAN HYPOTHETICAL PROTEIN BAA11502REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ku8 PRKG1 structures of pkgi reveal a cgmp-selective activation mechanism 1.99Å AUTH G.Y.HUANG,J.J.KIM,A.S.REGER,R.LORENZ,E.W.MOON,C.ZHAO,AUTH 2 D.E.CASTEEL,D.BERTINETTI,B.VANSCHOUWEN,R.SELVARATNAM,AUTH 3 J.W.PFLUGRATH,B.SANKARAN,G.MELACINI,F.W.HERBERG,C.KIMTITL STRUCTURAL BASIS FOR CYCLIC-NUCLEOTIDE SELECTIVITY ANDTITL 2 CGMP-SELECTIVE ACTIVATION OF PKG I.REF STRUCTURE V. 22 116 2014REFN ISSN 0969-2126PMID 24239458DOI 10.1016/J.STR.2013.09.021 Variant Set Distributions Mapped Variants
General Structure Information 2yrp NFATC4 solution structure of the tig domain from human nuclear factor of activated t-cells, cytoplasmic 4 -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE TIG DOMAIN FROM HUMANTITL 2 NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2csv TRIM29 solution structure of the zf-b_box type2 domain of human tripartite motif protein trim29 isoform alpha -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-B_BOX TYPE2 DOMAIN OFTITL 2 HUMAN TRIPARTITE MOTIF PROTEIN TRIM29 ISOFORM ALPHAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants