Assessment of Structural Intolerance and Durability
General Structure Information 3i8e DDB1 crystal structure of ddb1 in complex with the h-box motif of wdr42a 3.4Å AUTH T.LI,E.I.ROBERT,P.C.VAN BREUGEL,M.STRUBIN,N.ZHENGTITL A PROMISCUOUS ALPHA-HELICAL MOTIF ANCHORS VIRAL HIJACKERSTITL 2 AND SUBSTRATE RECEPTORS TO THE CUL4-DDB1 UBIQUITIN LIGASETITL 3 MACHINERY.REF NAT.STRUCT.MOL.BIOL. V. 17 105 2010REFN ISSN 1545-9993PMID 19966799DOI 10.1038/NSMB.1719 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3i7p DCAF12 crystal structure of ddb1 in complex with the h-box motif of wdr40a 3.0Å AUTH T.LI,E.I.ROBERT,P.C.VAN BREUGEL,M.STRUBIN,N.ZHENGTITL A PROMISCUOUS ALPHA-HELICAL MOTIF ANCHORS VIRALTITL 2 HIJACKERS AND SUBSTRATE RECEPTORS TO THE CUL4-DDB1TITL 3 UBIQUITIN LIGASE MACHINERY.REF NAT.STRUCT.MOL.BIOL. V. 17 105 2010REFN ISSN 1545-9993PMID 19966799DOI 10.1038/NSMB.1719 Variant Set Distributions Mapped Variants
General Structure Information 3h8x ALKBH2 structure determination of dna methylation lesions n1-mea and n3-mec in duplex dna using a cross-linked host-guest system 1.95Å AUTH L.LU,C.YI,X.JIAN,G.ZHENG,C.HETITL STRUCTURE DETERMINATION OF DNA METHYLATION LESIONS N1-MEATITL 2 AND N3-MEC IN DUPLEX DNA USING A CROSS-LINKED PROTEIN-DNATITL 3 SYSTEM.REF NUCLEIC ACIDS RES. V. 38 4415 2010REFN ISSN 0305-1048PMID 20223766DOI 10.1093/NAR/GKQ129 […]
General Structure Information 3cfv RBBP7 structural basis of the interaction of rbap46/rbap48 with histone h4 2.6Å AUTH N.V.MURZINA,X.Y.PEI,W.ZHANG,M.SPARKES,AUTH 2 J.VICENTE-GARCIA,J.V.PRATAP,S.H.MCLAUGHLIN,AUTH 3 T.R.BEN-SHAHAR,A.VERREAULT,B.F.LUISI,E.D.LAUETITL STRUCTURAL BASIS FOR THE RECOGNITION OF HISTONE H4TITL 2 BY THE HISTONE-CHAPERONE RBAP46.REF STRUCTURE V. 16 1077 2008REFN ISSN 0969-2126PMID 18571423DOI 10.1016/J.STR.2008.05.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3bua TERF2 crystal structure of trf2 trfh domain and apollo peptide complex 2.5Å AUTH Y.CHEN,Y.YANG,M.VAN OVERBEEK,J.R.DONIGIAN,P.BACIU,AUTH 2 T.DE LANGE,M.LEITITL A SHARED DOCKING MOTIF IN TRF1 AND TRF2 USED FORTITL 2 DIFFERENTIAL RECRUITMENT OF TELOMERIC PROTEINS.REF SCIENCE V. 319 1092 2008REFN ISSN 0036-8075PMID 18202258DOI 10.1126/SCIENCE.1151804 Variant Set Distributions Mapped Variants
General Structure Information 2me6 GBX1 nmr structure of the homeodomain transcription factor gbx1 from homo sapiens in complex with the dna sequence cgactaattagtcg -1.0Å AUTH A.PROUDFOOT,K.WUTHRICH,P.SERRANO,M.GERALTTITL NMR STRUCTURE OF THE HOMEODOMAIN TRANSCRIPTION FACTOR GBX1TITL 2 FROM HOMO SAPIENS IN COMPLEX WITH THE DNA SEQUENCETITL 3 CGACTAATTAGTCGREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4cgy TOP3A crystal structure of the human topoisomerase iii alpha-rmi1 complex 2.85Å AUTH N.BOCQUET,A.H.BIZARD,W.ABDULRAHMAN,N.B.LARSEN,M.FATY,AUTH 2 S.CAVADINI,R.D.BUNKER,S.C.KOWALCZYKOWSKI,P.CEJKA,AUTH 3 I.D.HICKSON,N.H.THOMATITL STRUCTURAL AND MECHANISTIC INSIGHT INTO HOLLIDAY-JUNCTIONTITL 2 DISSOLUTION BY TOPOISOMERASE IIIALPHA AND RMI1REF NAT.STRUCT.MOL.BIOL. V. 21 261 2014REFN ISSN 1545-9993PMID 24509834DOI 10.1038/NSMB.2775 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2oeh ARID5B determination of the three-dimensional structure of the mrf2-dna complex using paramagnetic spin labeling -1.0Å AUTH S.CAI,L.ZHU,Z.ZHANG,Y.CHENTITL DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURETITL 2 OF THE MRF2-DNA COMPLEX USING PARAMAGNETIC SPINTITL 3 LABELING.REF BIOCHEMISTRY V. 46 4943 2007REFN ISSN 0006-2960PMID 17407261DOI 10.1021/BI061738H Variant Set Distributions Mapped Variants
General Structure Information 1xv9 NR1I3 crystal structure of car/rxr heterodimer bound with src1 peptide, fatty acid, and 5b-pregnane-3,20-dione. 2.7Å AUTH R.X.XU,M.H.LAMBERT,B.B.WISELY,E.N.WARREN,AUTH 2 E.E.WEINERT,G.M.WAITT,J.D.WILLIAMS,J.L.COLLINS,AUTH 3 L.B.MOORE,T.M.WILLSON,J.T.MOORETITL A STRUCTURAL BASIS FOR CONSTITUTIVE ACTIVITY INTITL 2 THE HUMAN CAR/RXRALPHA HETERODIMER.REF MOL.CELL V. 16 919 2004REFN ISSN 1097-2765PMID 15610735DOI 10.1016/J.MOLCEL.2004.11.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]