Assessment of Structural Intolerance and Durability
General Structure Information 1d4u XPA interactions of human nucleotide excision repair protein xpa with rpa70 and dna: chemical shift mapping and 15n nmr relaxation studies -1.0Å AUTH G.W.BUCHKO,G.W.DAUGHDRILL,R.DE LORIMIER,K.RAO B,AUTH 2 N.G.ISERN,J.M.LINGBECK,J.S.TAYLOR,M.S.WOLD,AUTH 3 M.GOCHIN,L.D.SPICER,D.F.LOWRY,M.A.KENNEDYTITL INTERACTIONS OF HUMAN NUCLEOTIDE EXCISION REPAIRTITL 2 PROTEIN XPA WITH DNA AND RPA70 DELTA C327:TITL 3 CHEMICAL SHIFT MAPPING AND 15N […]
General Structure Information 3k77 XRCC1 x-ray crystal structure of xrcc1 2.6Å AUTH M.J.CUNEO,R.E.LONDONTITL OXIDATION STATE OF THE XRCC1 N-TERMINAL DOMAIN REGULATESTITL 2 DNA POLYMERASE BETA BINDING AFFINITY.REF PROC.NATL.ACAD.SCI.USA V. 107 6805 2010REFN ISSN 0027-8424PMID 20351257DOI 10.1073/PNAS.0914077107 Variant Set Distributions Mapped Variants
General Structure Information 7icp POLB dna polymerase beta (pol b) (e.c.2.7.7.7) complexed with six base pairs of dna; soaked in the presence of zncl2 (0.01 millimolar) 3.0Å AUTH H.PELLETIER,M.R.SAWAYA,W.WOLFLE,S.H.WILSON,J.KRAUTTITL A STRUCTURAL BASIS FOR METAL ION MUTAGENICITY ANDTITL 2 NUCLEOTIDE SELECTIVITY IN HUMAN DNA POLYMERASETITL 3 BETA.REF BIOCHEMISTRY V. 35 12762 1996REFN ISSN 0006-2960PMID 8841119DOI 10.1021/BI9529566 […]
General Structure Information 2jvn PARP1 domain c of human parp-1 -1.0Å AUTH Z.TAO,P.GAO,D.W.HOFFMAN,H.W.LIUTITL DOMAIN C OF HUMAN POLY(ADP-RIBOSE) POLYMERASE-1 IS IMPORTANTTITL 2 FOR ENZYME ACTIVITY AND CONTAINS A NOVEL ZINC-RIBBON MOTIF.REF BIOCHEMISTRY V. 47 5804 2008REFN ISSN 0006-2960PMID 18452307DOI 10.1021/BI800018A Variant Set Distributions Mapped Variants
General Structure Information 2cok PARP1 solution structure of brct domain of poly(adp-ribose) polymerase-1 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF BRCT DOMAIN OFTITL 2 POLY(ADP-RIBOSE) POLYMERASE-1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2a1i ERCC1 crystal structure of the central domain of human ercc1 1.9Å AUTH O.V.TSODIKOV,J.H.ENZLIN,O.D.SCHARER,T.ELLENBERGERTITL CRYSTAL STRUCTURE AND DNA BINDING FUNCTIONS OFTITL 2 ERCC1, A SUBUNIT OF THE DNA STRUCTURE-SPECIFICTITL 3 ENDONUCLEASE XPF-ERCC1.REF PROC.NATL.ACAD.SCI.USA V. 102 11236 2005REFN ISSN 0027-8424PMID 16076955DOI 10.1073/PNAS.0504341102 Variant Set Distributions Mapped Variants
General Structure Information 3ggr RAD1 crystal structure of the human rad9-hus1-rad1 complex 3.2Å AUTH M.XU,L.BAI,Y.GONG,W.XIE,H.Y.HANG,T.JIANGTITL STRUCTURE AND FUNCTIONAL IMPLICATIONS OF THE HUMANTITL 2 RAD9-HUS1-RAD1 CELL CYCLE CHECKPOINT COMPLEXREF J.BIOL.CHEM. V. 284 20457 2009REFN ISSN 0021-9258PMID 19535328DOI 10.1074/JBC.C109.022384 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3g65 HUS1 crystal structure of the human rad9-rad1-hus1 dna damage checkpoint complex 2.9Å AUTH A.S.DORE,M.L.KILKENNY,N.J.RZECHORZEK,L.H.PEARLTITL CRYSTAL STRUCTURE OF THE RAD9-RAD1-HUS1 DNA DAMAGETITL 2 CHECKPOINT COMPLEX–IMPLICATIONS FOR CLAMP LOADING ANDTITL 3 REGULATION.REF MOL.CELL V. 34 735 2009REFN ISSN 1097-2765PMID 19446481DOI 10.1016/J.MOLCEL.2009.04.027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4drb STRA13 the crystal structure of fancm bound mhf complex 2.63Å AUTH Y.TAO,C.JIN,X.LI,S.QI,L.CHU,L.NIU,X.YAO,M.TENGTITL THE STRUCTURE OF THE FANCM-MHF COMPLEX REVEALS PHYSICALTITL 2 FEATURES FOR FUNCTIONAL ASSEMBLYREF NAT COMMUN V. 3 782 2012REFN ESSN 2041-1723PMID 22510687DOI 10.1038/NCOMMS1779 Variant Set Distributions Mapped Variants