Assessment of Structural Intolerance and Durability
General Structure Information 3lgg CECR1 crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ada2) complexed with transition state analogue, coformycin 2.5Å AUTH A.V.ZAVIALOV,X.YU,D.SPILLMANN,G.LAUVAU,A.V.ZAVIALOVTITL STRUCTURAL BASIS FOR THE GROWTH FACTOR ACTIVITY OF HUMANTITL 2 ADENOSINE DEAMINASE ADA2.REF J.BIOL.CHEM. V. 285 12367 2010REFN ISSN 0021-9258PMID 20147294DOI 10.1074/JBC.M109.083527 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3rqf PDCD10 cerebral cavernous malformation 3 (ccm3) in complex with paxillin ld2 2.7Å AUTH X.LI,W.JI,R.ZHANG,E.FOLTA-STOGNIEW,W.MIN,T.J.BOGGONTITL MOLECULAR RECOGNITION OF LEUCINE-ASPARTATE REPEAT (LD)TITL 2 MOTIFS BY THE FOCAL ADHESION TARGETING HOMOLOGY DOMAIN OFTITL 3 CEREBRAL CAVERNOUS MALFORMATION 3 (CCM3).REF J.BIOL.CHEM. V. 286 26138 2011REFN ISSN 0021-9258PMID 21632544DOI 10.1074/JBC.M110.211250 Variant Set Distributions Mapped Variants
General Structure Information 3le4 DGCR8 crystal structure of the dgcr8 dimerization domain 1.7Å AUTH R.SENTURIA,M.FALLER,S.YIN,J.A.LOO,D.CASCIO,M.R.SAWAYA,AUTH 2 D.HWANG,R.T.CLUBB,F.GUOTITL STRUCTURE OF THE DIMERIZATION DOMAIN OF DIGEORGE CRITICALTITL 2 REGION 8REF PROTEIN SCI. V. 19 1354 2010REFN ISSN 0961-8368PMID 20506313DOI 10.1002/PRO.414 Variant Set Distributions Mapped Variants
General Structure Information 3twj ROCK1 rho-associated protein kinase 1 (rock 1) in complex with rki1447 2.9Å AUTH R.A.PATEL,K.D.FORINASH,R.PIREDDU,Y.SUN,N.SUN,M.P.MARTIN,AUTH 2 E.SCHONBRUNN,N.J.LAWRENCE,S.M.SEBTITITL RKI-1447 IS A POTENT INHIBITOR OF THE RHO-ASSOCIATED ROCKTITL 2 KINASES WITH ANTI-INVASIVE AND ANTITUMOR ACTIVITIES INTITL 3 BREAST CANCER.REF CANCER RES. V. 72 5025 2012REFN ISSN 0008-5472PMID 22846914DOI 10.1158/0008-5472.CAN-12-0954 Variant Set Distributions Ripley’s K […]
General Structure Information 3bua TERF2 crystal structure of trf2 trfh domain and apollo peptide complex 2.5Å AUTH Y.CHEN,Y.YANG,M.VAN OVERBEEK,J.R.DONIGIAN,P.BACIU,AUTH 2 T.DE LANGE,M.LEITITL A SHARED DOCKING MOTIF IN TRF1 AND TRF2 USED FORTITL 2 DIFFERENTIAL RECRUITMENT OF TELOMERIC PROTEINS.REF SCIENCE V. 319 1092 2008REFN ISSN 0036-8075PMID 18202258DOI 10.1126/SCIENCE.1151804 Variant Set Distributions Mapped Variants
General Structure Information 2lcx ERBB4 spatial structure of the erbb4 dimeric tm domain -1.0Å AUTH E.V.BOCHAROV,K.S.MINEEV,M.V.GONCHARUK,A.S.ARSENIEVTITL STRUCTURAL AND THERMODYNAMIC INSIGHT INTO THE PROCESS OFTITL 2 WEAK DIMERIZATION OF THE ERBB4 TRANSMEMBRANE DOMAIN BYTITL 3 SOLUTION NMR.REF BIOCHIM.BIOPHYS.ACTA V.1818 2158 2012REFN ISSN 0006-3002PMID 22579757DOI 10.1016/J.BBAMEM.2012.05.001 Variant Set Distributions Mapped Variants
General Structure Information 3u82 PVRL1 binding of herpes simplex virus glycoprotein d to nectin-1 exploits host cell adhesion 3.16Å AUTH N.ZHANG,J.YAN,G.LU,Z.GUO,Z.FAN,J.WANG,Y.SHI,J.QI,G.F.GAOTITL BINDING OF HERPES SIMPLEX VIRUS GLYCOPROTEIN D TO NECTIN-1TITL 2 EXPLOITS HOST CELL ADHESION.REF NAT COMMUN V. 2 577 2011REFN ESSN 2041-1723PMID 22146396DOI 10.1038/NCOMMS1571 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3u82 PVRL1 binding of herpes simplex virus glycoprotein d to nectin-1 exploits host cell adhesion 3.16Å AUTH N.ZHANG,J.YAN,G.LU,Z.GUO,Z.FAN,J.WANG,Y.SHI,J.QI,G.F.GAOTITL BINDING OF HERPES SIMPLEX VIRUS GLYCOPROTEIN D TO NECTIN-1TITL 2 EXPLOITS HOST CELL ADHESION.REF NAT COMMUN V. 2 577 2011REFN ESSN 2041-1723PMID 22146396DOI 10.1038/NCOMMS1571 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3u82 PVRL1 binding of herpes simplex virus glycoprotein d to nectin-1 exploits host cell adhesion 3.16Å AUTH N.ZHANG,J.YAN,G.LU,Z.GUO,Z.FAN,J.WANG,Y.SHI,J.QI,G.F.GAOTITL BINDING OF HERPES SIMPLEX VIRUS GLYCOPROTEIN D TO NECTIN-1TITL 2 EXPLOITS HOST CELL ADHESION.REF NAT COMMUN V. 2 577 2011REFN ESSN 2041-1723PMID 22146396DOI 10.1038/NCOMMS1571 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3mq4 GRM7 metabotropic glutamate receptor mglur7 complexed with ly341495 antagonist 2.8Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,H.HE,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,A.BOCHKAREVTITL MGLUR7 COMPLEXED WITH LY341495REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants