Assessment of Structural Intolerance and Durability
General Structure Information 2v9r ROBO1 first and second ig domains from human robo1 (form 2) 2.0Å AUTH C.MORLOT,N.M.THIELENS,R.B.RAVELLI,W.HEMRIKA,R.A.ROMIJN,AUTH 2 P.GROS,S.CUSACK,A.A.MCCARTHYTITL STRUCTURAL INSIGHTS INTO THE SLIT-ROBO COMPLEX.REF PROC.NAT.ACAD.SCI.USA V. 104 14923 2007REFN ISSN 0027-8424PMID 17848514DOI 10.1073/PNAS.0705310104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bin EPB41L3 structure of the dal-1 and tslc1 (372-383) complex 2.3Å AUTH R.D.BUSAM,A.-G.THORSELL,A.FLORES,M.HAMMARSTROM,C.PERSSON,AUTH 2 B.OBRINK,B.M.HALLBERGTITL STRUCTURAL BASIS OF TUMOR SUPPRESSOR IN LUNG CANCER 1TITL 2 (TSLC1) BINDING TO DIFFERENTIALLY EXPRESSED INTITL 3 ADENOCARCINOMA OF THE LUNG (DAL-1/4.1B)REF J.BIOL.CHEM. V. 286 4511 2011REFN ISSN 0021-9258PMID 21131357DOI 10.1074/JBC.M110.174011 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2rb4 DDX25 crystal structure of the helicase domain of human ddx25 rna helicase 2.8Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 2k40 HESX1 nmr structure of hesx-1 homeodomain double mutant r31l/e42l -1.0Å AUTH J.ASENSIO,M.TORRADO,C.GONZALEZ,A.BASTIDA,F.CORZANATITL THE ROLE OF CONSERVED SALT-BRIDGES ON HOMEODOMAINTITL 2 STABILITYREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3lyr EBF1 human early b-cell factor 1 (ebf1) dna-binding domain 2.51Å AUTH M.I.SIPONEN,M.WISNIEWSKA,L.LEHTIO,I.JOHANSSON,L.SVENSSON,AUTH 2 G.RASZEWSKI,L.NILSSON,M.SIGVARDSSON,H.BERGLUNDTITL STRUCTURAL DETERMINATION OF FUNCTIONAL DOMAINS IN EARLYTITL 2 B-CELL FACTOR (EBF) FAMILY OF TRANSCRIPTION FACTORS REVEALSTITL 3 SIMILARITIES TO REL DNA-BINDING PROTEINS AND A NOVELTITL 4 DIMERIZATION MOTIF.REF J.BIOL.CHEM. V. 285 25875 2010REFN ISSN 0021-9258PMID 20592035DOI 10.1074/JBC.C110.150482 […]
General Structure Information 2rmn TP63 the solution structure of the p63 dna-binding domain -1.0Å AUTH A.ENTHART,J.FURRER,A.DEHNER,H.KESSLERTITL SOLUTION STRUCTURE AND BINDING STUDIES OF THE P63TITL 2 DNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2x6u TBX5 crystal structure of human tbx5 in the dna-free form 1.9Å AUTH C.U.STIRNIMANN,D.PTCHELKINE,C.GRIMM,C.W.MULLERTITL STRUCTURAL BASIS OF TBX5-DNA RECOGNITION: THE T-TITL 2 BOX DOMAIN IN ITS DNA-BOUND AND -UNBOUND FORM.REF J.MOL.BIOL. V. 400 71 2010REFN ISSN 0022-2836PMID 20450920DOI 10.1016/J.JMB.2010.04.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2v66 NDEL1 crystal structure of the coiled-coil domain of ndel1 (a.a. 58 to 169)c 2.1Å AUTH U.DEREWENDA,C.TARRICONE,W.C.CHOI,D.R.COOPER,S.LUKASIK,AUTH 2 F.PERRINA,A.TRIPATHY,M.H.KIM,D.S.CAFISO,A.MUSACCHIO,AUTH 3 Z.S.DEREWENDATITL THE STRUCTURE OF THE COILED-COIL DOMAIN OF NDEL1 AND THETITL 2 BASIS OF ITS INTERACTION WITH LIS1, THE CAUSAL PROTEIN OFTITL 3 MILLER-DIEKER LISSENCEPHALY.REF STRUCTURE V. 15 1467 2007REFN ISSN 0969-2126PMID […]
General Structure Information 3f6k SORT1 crystal structure of the vps10p domain of human sortilin/nts3 in complex with neurotensin 2.0Å AUTH E.M.QUISTGAARD,P.MADSEN,M.K.GROFTEHAUGE,P.NISSEN,AUTH 2 C.M.PETERSEN,S.S.THIRUPTITL LIGANDS BIND TO SORTILIN IN THE TUNNEL OF A TEN-BLADEDTITL 2 BETA-PROPELLER DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 16 96 2009REFN ISSN 1545-9993PMID 19122660DOI 10.1038/NSMB.1543 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4b91 DPYSL5 crystal structure of truncated human crmp-5 1.7Å AUTH R.PONNUSAMY,B.LOHKAMPTITL INSIGHTS INTO THE OLIGOMERIZATION OF CRMPS: CRYSTALTITL 2 STRUCTURE OF HUMAN COLLAPSIN RESPONSE MEDIATOR PROTEIN 5.REF J.NEUROCHEM. V. 125 855 2013REFN ISSN 0022-3042PMID 23373749DOI 10.1111/JNC.12188 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants