Assessment of Structural Intolerance and Durability
General Structure Information 2v9r ROBO1 first and second ig domains from human robo1 (form 2) 2.0Å AUTH C.MORLOT,N.M.THIELENS,R.B.RAVELLI,W.HEMRIKA,R.A.ROMIJN,AUTH 2 P.GROS,S.CUSACK,A.A.MCCARTHYTITL STRUCTURAL INSIGHTS INTO THE SLIT-ROBO COMPLEX.REF PROC.NAT.ACAD.SCI.USA V. 104 14923 2007REFN ISSN 0027-8424PMID 17848514DOI 10.1073/PNAS.0705310104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2os6 ARHGEF12 solution structure of larg pdz domain in complex with c- terminal octa-peptide of plexin b1 -1.0Å AUTH J.LIU,H.HUANG,Y.YANGTITL SOLUTION STRUCTURE OF THE LARG PDZ DOMAIN INTITL 2 COMPLEX WITH C-TERMINAL PEPTIDE OF PLEXIN B1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2q4k C11orf68 ensemble refinement of the protein crystal structure of gene product from homo sapiens hs.433573 2.5Å AUTH E.J.LEVIN,D.A.KONDRASHOV,G.E.WESENBERG,G.N.PHILLIPSTITL ENSEMBLE REFINEMENT OF PROTEIN CRYSTAL STRUCTURES:TITL 2 VALIDATION AND APPLICATION.REF STRUCTURE V. 15 1040 2007REFN ISSN 0969-2126PMID 17850744DOI 10.1016/J.STR.2007.06.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jfl SLK crystal structure of human ste20-like kinase ( diphosphorylated form) bound to 5- amino-3-((4-( aminosulfonyl)phenyl)amino)-n-(2,6- difluorophenyl)-1h-1,2, 4-triazole-1-carbothioamide 2.2Å AUTH A.C.W.PIKE,P.RELLOS,F.H.NIESEN,A.TURNBULL,A.W.OLIVER,AUTH 2 S.A.PARKER,B.E.TURK,L.H.PEARL,S.KNAPPTITL ACTIVATION SEGMENT DIMERIZATION: A MECHANISM FOR KINASETITL 2 AUTOPHOSPHORYLATION OF NON-CONSENSUS SITES.REF EMBO J. V. 27 704 2008REFN ISSN 0261-4189PMID 18239682DOI 10.1038/EMBOJ.2008.8 Variant Set Distributions Mapped Variants
General Structure Information 2l9r NKX3-1 solution nmr structure of homeobox domain of homeobox protein nkx-3.1 from homo sapiens, northeast structural genomics consortium target hr6470a -1.0Å AUTH G.LIU,R.XIAO,H.-W.LEE,K.HAMILTON,C.CICCOSANTI,H.B.WANG,AUTH 2 T.B.ACTON,J.K.EVERETT,Y.J.HUANG,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF HOMEOBOX DOMAIN OF HOMEOBOXTITL 2 PROTEIN NKX-3.1 FROM HOMO SAPIENS, NORTHEAST STRUCTURALTITL 3 GENOMICS CONSORTIUM TARGET HR6470AREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2wft HHIP crystal structure of the human hip ectodomain 2.8Å AUTH B.BISHOP,A.R.ARICESCU,K.HARLOS,C.A.OCALLAGHAN,AUTH 2 E.Y.JONES,C.SIEBOLDTITL STRUCTURAL INSIGHTS INTO HEDGEHOG LIGANDTITL 2 SEQUESTRATION BY THE HUMAN HEDGEHOG-INTERACTINGTITL 3 PROTEIN HIPREF NAT.STRUCT.MOL.BIOL. V. 16 698 2009REFN ISSN 1545-9993PMID 19561611DOI 10.1038/NSMB.1607 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yse SATB1 solution structure of the mar-binding domain of satb1 -1.0Å AUTH H.YAMAGUCHI,M.TATENO,K.YAMASAKITITL SOLUTION STRUCTURE AND DNA-BINDING MODE OF THETITL 2 MATRIX ATTACHMENT REGION-BINDING DOMAIN OF THETITL 3 TRANSCRIPTION FACTOR SATB1 THAT REGULATES THETITL 4 T-CELL MATURATIONREF J.BIOL.CHEM. V. 281 5319 2006REFN ISSN 0021-9258PMID 16371359DOI 10.1074/JBC.M510933200 Variant Set Distributions Mapped Variants
General Structure Information 4my2 NDP crystal structure of norrin in fusion with maltose binding protein 2.4Å AUTH J.KE,K.G.HARIKUMAR,C.ERICE,C.CHEN,X.GU,L.WANG,N.PARKER,AUTH 2 Z.CHENG,W.XU,B.O.WILLIAMS,K.MELCHER,L.J.MILLER,H.E.XUTITL STRUCTURE AND FUNCTION OF NORRIN IN ASSEMBLY AND ACTIVATIONTITL 2 OF A FRIZZLED 4-LRP5/6 COMPLEX.REF GENES DEV. V. 27 2305 2013REFN ISSN 0890-9369PMID 24186977DOI 10.1101/GAD.228544.113 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yse SATB1 solution structure of the mar-binding domain of satb1 -1.0Å AUTH H.YAMAGUCHI,M.TATENO,K.YAMASAKITITL SOLUTION STRUCTURE AND DNA-BINDING MODE OF THETITL 2 MATRIX ATTACHMENT REGION-BINDING DOMAIN OF THETITL 3 TRANSCRIPTION FACTOR SATB1 THAT REGULATES THETITL 4 T-CELL MATURATIONREF J.BIOL.CHEM. V. 281 5319 2006REFN ISSN 0021-9258PMID 16371359DOI 10.1074/JBC.M510933200 Variant Set Distributions Mapped Variants
General Structure Information 4my2 NDP crystal structure of norrin in fusion with maltose binding protein 2.4Å AUTH J.KE,K.G.HARIKUMAR,C.ERICE,C.CHEN,X.GU,L.WANG,N.PARKER,AUTH 2 Z.CHENG,W.XU,B.O.WILLIAMS,K.MELCHER,L.J.MILLER,H.E.XUTITL STRUCTURE AND FUNCTION OF NORRIN IN ASSEMBLY AND ACTIVATIONTITL 2 OF A FRIZZLED 4-LRP5/6 COMPLEX.REF GENES DEV. V. 27 2305 2013REFN ISSN 0890-9369PMID 24186977DOI 10.1101/GAD.228544.113 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants