Assessment of Structural Intolerance and Durability
General Structure Information 2dfd MDH2 crystal structure of human malate dehydrogenase type 2 1.9Å AUTH E.UGOCHUKWU,N.SHAFQAT,A.ROJKOVA,M.SUNDSTROM,C.ARROWSMITH,AUTH 2 J.WEIGELT,A.EDWARDS,F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN MALATE DEHYDROGENASE TYPE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4oe5 ALDH4A1 structure of human aldh4a1 crystallized in space group p21 1.95Å AUTH T.A.PEMBERTON,D.SRIVASTAVA,N.SANYAL,M.T.HENZL,D.F.BECKER,AUTH 2 J.J.TANNERTITL STRUCTURAL STUDIES OF YEAST DELTATITL 2 (1)-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (ALDH4A1): ACTIVETITL 3 SITE FLEXIBILITY AND OLIGOMERIC STATE.REF BIOCHEMISTRY V. 53 1350 2014REFN ISSN 0006-2960PMID 24502590DOI 10.1021/BI500048B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1wpq GPD1 ternary complex of glycerol 3-phosphate dehydrogenase 1 with nad and dihydroxyactone 2.5Å AUTH X.OU,C.JI,X.HAN,X.ZHAO,X.LI,Y.MAO,L.L.WONG,AUTH 2 M.BARTLAM,Z.RAOTITL CRYSTAL STRUCTURES OF HUMAN GLYCEROL 3-PHOSPHATETITL 2 DEHYDROGENASE 1 (GPD1)REF J.MOL.BIOL. V. 357 858 2006REFN ISSN 0022-2836PMID 16460752DOI 10.1016/J.JMB.2005.12.074 Variant Set Distributions Mapped Variants
General Structure Information 1nfb IMPDH2 ternary complex of the human type ii inosine monophosphate dedhydrogenase with 6cl-imp and nad 2.9Å AUTH D.RISAL,M.D.STRICKLER,B.M.GOLDSTEINTITL THE CONFORMATION OF NAD BOUND TO HUMAN INOSINE MONOPHOSPHATETITL 2 DEHYDROGENASE TYPE IIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gdz HPGD crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with nad+ 1.65Å AUTH F.H.NIESEN,L.SCHULTZ,A.JADHAV,C.BHATIA,K.GUO,D.J.MALONEY,AUTH 2 E.S.PILKA,M.WANG,U.OPPERMANN,T.D.HEIGHTMAN,A.SIMEONOVTITL HIGH-AFFINITY INHIBITORS OF HUMAN NAD-DEPENDENTTITL 2 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE: MECHANISMS OFTITL 3 INHIBITION AND STRUCTURE-ACTIVITY RELATIONSHIPS.REF PLOS ONE V. 5 E1371 2010REFN ESSN 1932-6203PMID 21072165DOI 10.1371/JOURNAL.PONE.0013719 Variant Set Distributions Mapped Variants
General Structure Information 1dig MTHFD1 human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with nadp and inhibitor ly374571 2.2Å AUTH A.SCHMIDT,H.WU,R.E.MACKENZIE,V.J.CHEN,J.R.BEWLY,AUTH 2 J.E.RAY,J.E.TOTH,M.CYGLERTITL STRUCTURES OF THREE INHIBITOR COMPLEXES PROVIDETITL 2 INSIGHT INTO THE REACTION MECHANISM OF THE HUMANTITL 3 METHYLENETETRAHYDROFOLATETITL 4 DEHYDROGENASE/CYCLOHYDROLASE.REF BIOCHEMISTRY V. 39 6325 2000REFN ISSN 0006-2960PMID 10828945DOI 10.1021/BI992734Y Variant Set Distributions Mapped Variants
General Structure Information 2bw0 ALDH1L1 crystal structure of the hydrolase domain of human 10-formyltetrahydrofolate 2 dehydrogenase 1.7Å AUTH P.KURSULA,H.SCHULER,S.FLODIN,P.NILSSON-EHLE,AUTH 2 D.J.OGG,P.SAVITSKY,P.NORDLUND,P.STENMARKTITL STRUCTURES OF THE HYDROLASE DOMAIN OF HUMAN 10-TITL 2 FORMYLTETRAHYDROFOLATE DEHYDROGENASE AND ITSTITL 3 COMPLEX WITH A SUBSTRATE ANALOGUE.REF ACTA CRYSTALLOGR.,SECT.D V. 62 1294 2006REFN ISSN 0907-4449PMID 17057331DOI 10.1107/S0907444906026849 Variant Set Distributions Ripley’s K […]
General Structure Information 2hrb CBR3 crystal structure of human carbonyl reductase 3, complexed with nadp+ 1.9Å AUTH E.S.PILKA,A.ROJKOVA,K.L.KAVANAGH,F.NIESEN,M.SUNDSTROM,AUTH 2 C.ARROWSMITH,J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN CARBONYL REDUCTASE 3, COMPLEXEDTITL 2 WITH NADP+REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants