Assessment of Structural Intolerance and Durability
General Structure Information 3eh1 SEC24B crystal structure of the human copii-coat protein sec24b 1.8Å AUTH J.D.MANCIAS,J.GOLDBERGTITL STRUCTURAL BASIS OF CARGO MEMBRANE PROTEINTITL 2 DISCRIMINATION BY THE HUMAN COPII COAT MACHINERY.REF EMBO J. V. 27 2918 2008REFN ISSN 0261-4189PMID 18843296DOI 10.1038/EMBOJ.2008.208 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2k6m SVIL solution structure of human supervillin headpiece -1.0Å AUTH J.W.BROWN,D.VARDAR-ULU,C.J.MCKNIGHTTITL HOW TO ARM A SUPERVILLIN: DESIGNING F-ACTIN BINDINGTITL 2 ACTIVITY INTO SUPERVILLIN HEADPIECE.REF J.MOL.BIOL. V. 393 608 2009REFN ISSN 0022-2836PMID 19683541DOI 10.1016/J.JMB.2009.08.018 Variant Set Distributions Mapped Variants
General Structure Information 3i2v MOCS3 crystal structure of human mocs3 rhodanese-like domain 1.25Å AUTH J.P.BACIK,J.R.WALKER,L.LOPEZ,Y.LI,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF THE HUMAN MOCS3 RHODANESE-LIKETITL 2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3e6u LANCL1 crystal structure of human lancl1 2.6Å AUTH W.ZHANG,L.WANG,Y.LIU,J.XU,G.ZHU,H.CANG,X.LI,AUTH 2 M.BARTLAM,K.HENSLEY,G.LI,Z.RAO,X.C.ZHANGTITL STRUCTURE OF HUMAN LANTHIONINE SYNTHETASE C-LIKETITL 2 PROTEIN 1 AND ITS INTERACTION WITH EPS8 ANDTITL 3 GLUTATHIONEREF GENES DEV. V. 23 1387 2009REFN ISSN 0890-9369PMID 19528316DOI 10.1101/GAD.1789209 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2jxb NCK2 structure of cd3epsilon-nck2 first sh3 domain complex -1.0Å AUTH K.TAKEUCHI,H.YANG,E.NG,S.Y.PARK,Z.Y.SUN,AUTH 2 E.L.REINHERZ,G.WAGNERTITL STRUCTURAL AND FUNCTIONAL EVIDENCE THAT NCKTITL 2 INTERACTION WITH CD3EPSILON REGULATES T-CELLTITL 3 RECEPTOR ACTIVITY.REF J.MOL.BIOL. V. 380 704 2008REFN ISSN 0022-2836PMID 18555270DOI 10.1016/J.JMB.2008.05.037 Variant Set Distributions Mapped Variants
General Structure Information 2k4p INPPL1 solution structure of ship2-sam -1.0Å AUTH M.LEONE,J.CELLITTI,M.PELLECCHIATITL NMR STUDIES OF A HETEROTYPIC SAM-SAM DOMAINTITL 2 ASSOCIATION: THE INTERACTION BETWEEN THE LIPIDTITL 3 PHOSPHATASE SHIP2 AND THE EPHA2 RECEPTOR.REF BIOCHEMISTRY V. 47 12721 2008REFN ISSN 0006-2960PMID 18991394DOI 10.1021/BI801713F Variant Set Distributions Mapped Variants
General Structure Information 2jun MID1 structure of the mid1 tandem b-boxes reveals an interaction reminiscent of intermolecular ring heterodimers -1.0Å AUTH H.TAO,B.N.SIMMONS,S.SINGIREDDY,M.JAKKIDI,K.M.SHORT,AUTH 2 T.C.COX,M.A.MASSIAHTITL STRUCTURE OF THE MID1 TANDEM B-BOXES REVEALS ANTITL 2 INTERACTION REMINISCENT OF INTERMOLECULAR RINGTITL 3 HETERODIMERSREF BIOCHEMISTRY V. 47 2450 2008REFN ISSN 0006-2960PMID 18220417DOI 10.1021/BI7018496 Variant Set Distributions Mapped Variants
General Structure Information 3iug ARHGAP32 crystal structure of the rhogap domain of rics 1.77Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,Y.LI,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF RICSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bfx SULT1C2 crystal structure of human sulfotransferase sult1c1 in complex with pap 1.8Å AUTH L.DOMBROVSKI,A.DONG,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURES OF HUMAN SULFOTRANSFERASESTITL 2 SULT1B1 AND SULT1C1 COMPLEXED WITH THE COFACTORTITL 3 PRODUCT ADENOSINE-3-5-DIPHOSPHATE (PAP).REF PROTEINS V. 64 1091 2006REFN ISSN 0887-3585PMID 16804942DOI 10.1002/PROT.21048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2k86 FOXO3 solution structure of foxo3a forkhead domain -1.0Å AUTH F.WANG,C.B.MARSHALL,K.YAMAMOTO,G.Y.LI,M.J.PLEVIN,AUTH 2 H.YOU,T.W.MAK,M.IKURATITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF ANTITL 2 INTRAMOLECULAR INTERACTION IN FOXO3A AND ITSTITL 3 BINDING WITH P53.REF J.MOL.BIOL. V. 384 590 2008REFN ISSN 0022-2836PMID 18824006DOI 10.1016/J.JMB.2008.09.025 Variant Set Distributions Mapped Variants