Assessment of Structural Intolerance and Durability
General Structure Information 2dm8 INADL solution structure of the eighth pdz domain of human inad- like protein -1.0Å AUTH K.INOUE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE EIGHTH PDZ DOMAIN OFTITL 2 HUMAN INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4geb AADAT kynurenine aminotransferase ii inhibitors 2.15Å AUTH A.B.DOUNAY,M.ANDERSON,B.M.BECHLE,E.EVRARD,X.GAN,J.Y.KIM,AUTH 2 L.A.MCALLISTER,J.PANDIT,S.RONG,M.A.SALAFIA,J.B.TUTTLE,AUTH 3 L.E.ZAWADZKE,P.R.VERHOESTTITL PF-04859989 AS A TEMPLATE FOR STRUCTURE-BASED DRUG DESIGN:TITL 2 IDENTIFICATION OF NEW PYRAZOLE SERIES OF IRREVERSIBLE KAT IITITL 3 INHIBITORS WITH IMPROVED LIPOPHILIC EFFICIENCY.REF BIOORG.MED.CHEM.LETT. V. 23 1961 2013REFN ISSN 0960-894XPMID 23466229DOI 10.1016/J.BMCL.2013.02.039 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1mi1 NBEA crystal structure of the ph-beach domain of human neurobeachin 2.9Å AUTH G.JOGL,Y.SHEN,D.GEBAUER,J.LI,K.WIEGMANN,H.KASHKAR,AUTH 2 M.KRONKE,L.TONGTITL CRYSTAL STRUCTURE OF THE BEACH DOMAIN REVEALS ANTITL 2 UNUSUAL FOLD AND EXTENSIVE ASSOCIATION WITH ATITL 3 NOVEL PH DOMAIN.REF EMBO J. V. 21 4785 2002REFN ISSN 0261-4189PMID 12234919DOI 10.1093/EMBOJ/CDF502 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1yb1 HSD17B11 crystal structure of human 17-beta-hydroxysteroid dehydrogenase type xi 1.95Å AUTH P.LUKACIK,G.BUNKOCZI,K.KAVANAGH,S.NG,F.VON DELFT,J.BRAY,AUTH 2 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROIDTITL 2 DEHYDROGENASE TYPE XI.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3gcw PCSK9 pcsk9:egfa(h306y) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2yre FBXO30 solution structure of the zinc finger domains (1-87) from human f-box only protein -1.0Å AUTH T.NAGASHIMA,T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZINC FINGER DOMAINSTITL 2 (1-87) FROM HUMAN F-BOX ONLY PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ysm KMT2C solution structure of the first and second phd domain from myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST AND SECOND PHDTITL 2 DOMAIN FROM MYELOID/LYMPHOID OR MIXED-LINEAGETITL 3 LEUKEMIA PROTEIN 3 HOMOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3v42 FLCN crystal structure of renal tumor suppressor protein, folliculin 2.0Å AUTH R.K.NOOKALA,L.LANGEMEYER,A.PACITTO,B.OCHOA-MONTANO,AUTH 2 J.C.DONALDSON,B.K.BLASZCZYK,D.Y.CHIRGADZE,F.A.BARR,AUTH 3 J.F.BAZAN,T.L.BLUNDELLTITL CRYSTAL STRUCTURE OF FOLLICULIN REVEALS A HIDDENN FUNCTIONTITL 2 IN GENETICALLY INHERITED RENAL CANCER.REF OPEN BIOL V. 2 20071 2012REFNPMID 22977732DOI 10.1098/RSOB.120071 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4da1 PPM1K crystal structure of branched-chain alpha-ketoacid dehydrogenase phosphatase with mg (ii) ions at the active site 2.38Å AUTH R.M.WYNN,J.LI,C.A.BRAUTIGAM,J.L.CHUANG,D.T.CHUANGTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMANTITL 2 MITOCHONDRIAL BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASETITL 3 PHOSPHATASE.REF J.BIOL.CHEM. V. 287 9178 2012REFN ISSN 0021-9258PMID 22291014DOI 10.1074/JBC.M111.314963 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3smp PANK1 monoclinic crystal structure of human pantothenate kinase 1 alpha 1.9Å AUTH X.GUAN,W.TEMPEL,B.HONG,A.K.WERNIMONT,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL MONOCLINIC CRYSTAL STRUCTURE OF HUMAN PANTOTHENATE KINASE 1TITL 2 ALPHAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants