Assessment of Structural Intolerance and Durability
General Structure Information 3p1i EPHB3 ligand binding domain of human ephrin type-b receptor 3 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,A.SEITOVA,J.KANIA,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL LIGAND BINDING DOMAIN OF HUMAN EPHB3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2olm AGFG1 arfgap domain of hiv-1 rev binding protein 1.48Å AUTH Y.TONG,W.TEMPEL,L.SHEN,S.DIMOV,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARK,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL ARFGAP DOMAIN OF HIV-1 REV BINDING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hm8 HK3 crystal structure of the c-terminal hexokinase domain of human hk3 2.8Å AUTH L.NEDYALKOVA,Y.TONG,W.RABEH,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE C-TERMINAL HEXOKINASE DOMAIN OFTITL 2 HUMAN HK3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hlz KHK crystal structure of human ketohexokinase (casp target) 1.85Å AUTH W.M.RABEH,W.TEMPEL,L.NEDYALKOVA,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN KETOHEXOKINASE (CASPTITL 2 TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2es0 RGS6 structure of the regulator of g-protein signaling domain of rgs6 2.1Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2h63 BLVRA crystal structure of human biliverdin reductase a (casp target) 2.7Å AUTH K.KAVANAGH,J.ELKINS,E.UGOCHUKWU,K.GUO,E.PILKA,AUTH 2 P.LUKACIK,C.SMEE,E.PAPAGRIGORIOU,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BILIVERDIN REDUCTASE AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2aw5 ME1 crystal structure of a human malic enzyme 2.5Å AUTH E.PAPAGRIGORIOU,G.BERRIDGE,C.SMEE,J.BRAY,AUTH 2 C.ARROWSMITH,A.EDWARDS,J.WEIGELT,M.SUNDSTROM,AUTH 3 U.OPPERMANN,O.GILEADI,F.VON DELFTTITL CRYSTAL STRUCTURE OF A HUMAN MALIC ENZYMEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3sog AMPH crystal structure of the bar domain of human amphiphysin, isoform 1 2.3Å Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bzh UBE2E1 crystal structure of human ubiquitin-conjugating enzyme e2 e1 1.6Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 2ppl PNLIPRP1 human pancreatic lipase-related protein 1 2.2Å AUTH J.R.WALKER,T.DAVIS,A.SEITOVA,C.BUTLER-COLE,AUTH 2 J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE HUMAN PANCREATIC LIPASE-RELATEDTITL 2 PROTEIN 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants