Assessment of Structural Intolerance and Durability
General Structure Information 4hbd KANK2 crystal structure of kank2 ankyrin repeats 1.72Å AUTH C.XU,W.TEMPEL,T.CEROVINA,M.EL BAKKOURI,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MINTITL CRYSTAL STRUCTURE OF KANK2 ANKYRIN REPEATSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3o46 MPP7 crystal structure of the pdz domain of mpp7 1.3Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,N.ZHONG,X.GUAN,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF MPP7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2h8k SULT1C3 human sulfotranferase sult1c3 in complex with pap 3.2Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,AUTH 2 R.NAJMANOVICH,W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,AUTH 3 J.THORNTON,J.THONTON,A.M.EDWARDS,A.BOCHKAREV,AUTH 4 A.N.PLOTNIKOV,M.VEDADI,C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMANTITL 2 CYTOSOLIC SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1zdn UBE2S ubiquitin-conjugating enzyme e2s 1.93Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 3mqp BCL2A1 crystal structure of human bfl-1 in complex with noxa bh3 peptide, northeast structural genomics consortium target hr2930 2.24Å AUTH R.GUAN,R.XIAO,L.ZHAO,T.B.ACTON,C.GELINAS,G.T.MONTELIONETITL CRYSTAL STRUCTURE OF HUMAN BFL-1 IN COMPLEX WITH NOXA BH3TITL 2 PEPTIDEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2oq0 IFI16 crystal structure of the first hin-200 domain of interferon-inducible protein 16 2.0Å AUTH J.C.C.LIAO,R.LAM,M.RAVICHANDRAN,J.MA,W.TEMPEL,N.Y.CHIRGADZE,AUTH 2 C.H.ARROWSMITHTITL CRYSTAL STRUCTURE OF THE FIRST HIN-200 DOMAIN OFTITL 2 INTERFERON-INDUCIBLE PROTEIN 16REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dai ATAD2 crystal structure of the bromodomain of the human atad2 1.95Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 4flb RPRD2 cid of human rprd2 1.8Å AUTH Z.NI,C.XU,X.GUO,G.O.HUNTER,O.V.KUZNETSOVA,W.TEMPEL,E.MARCON,AUTH 2 G.ZHONG,H.GUO,W.H.KUO,J.LI,P.YOUNG,J.B.OLSEN,C.WAN,AUTH 3 P.LOPPNAU,M.EL BAKKOURI,G.A.SENISTERRA,H.HE,H.HUANG,AUTH 4 S.S.SIDHU,A.EMILI,S.MURPHY,A.L.MOSLEY,C.H.ARROWSMITH,J.MIN,AUTH 5 J.F.GREENBLATTTITL RPRD1A AND RPRD1B ARE HUMAN RNA POLYMERASE II C-TERMINALTITL 2 DOMAIN SCAFFOLDS FOR SER5 DEPHOSPHORYLATION.REF NAT.STRUCT.MOL.BIOL. V. 21 686 2014REFN ISSN 1545-9993PMID 24997600DOI 10.1038/NSMB.2853 Variant Set Distributions Mapped Variants
General Structure Information 3hkv PARP10 human poly(adp-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide 2.1Å AUTH T.KARLBERG,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,A.KOTZSCH,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,J.SAGEMARK,P.SCHUTZ,AUTH 6 M.I.SIPONEN,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 8 H.SCHULERTITL HUMAN POLY(ADP-RIBOSE) POLYMERASE 10, CATALYTICTITL 2 FRAGMENT IN COMPLEX WITH AN INHIBITORTITL 3 3-AMINOBENZAMIDEREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2hq6 CWC27 structure of the cyclophilin_cecyp16-like domain of the serologically defined colon cancer antigen 10 from homo sapiens 1.75Å AUTH J.R.WALKER,T.DAVIS,R.PARAMANATHAN,E.M.NEWMAN,AUTH 2 P.J.FINERTY JR.,F.MACKENZIE,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE CYCLOPHILIN_CECYP16-LIKE DOMAIN OF THETITL 2 SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 10REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants