Assessment of Structural Intolerance and Durability
General Structure Information 3f3s CRYL1 the crystal structure of human lambda-crystallin, cryl1 2.0Å AUTH E.UGOCHUKWU,C.JOHANSSON,W.W.YUE,G.KOCHAN,E.PILKA,A.KRAMM,AUTH 2 A.C.W.PIKE,P.FILIPPAKOPOULOS,F.VON DELFT,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN LAMBDA-CRYSTALLIN, CRYL1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l8n ARFGEF2 crystal structure of a domain of brefeldin a-inhibited guanine nucleotide-exchange protein 2 (brefeldina-inhibited gep 2) from homo sapiens (human). northeast structural genomics consortium target id hr5562a 2.86Å AUTH J.SEETHARAMAN,M.SU,F.FOROUHAR,D.WANG,H.JANJUA,AUTH 2 K.CUNNINGHAM,L.OWENS,R.XIAO,J.LIU,M.C.BARAN,AUTH 3 T.B.ACTON,G.T.MONTELIONE,J.F.HUNT,L.TONGTITL CRYSTAL STRUCTURE OF A DOMAIN OF BREFELDINTITL 2 A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2TITL 3 (BREFELDINA-INHIBITED GEP 2) […]
General Structure Information 1tvg HSPB11 x-ray structure of human pp25 gene product, hspc034. northeast structural genomics target hr1958. 1.6Å AUTH T.A.RAMELOT,S.RAMAN,A.P.KUZIN,R.XIAO,L.C.MA,AUTH 2 T.B.ACTON,J.F.HUNT,G.T.MONTELIONE,D.BAKER,AUTH 3 M.A.KENNEDYTITL IMPROVING NMR PROTEIN STRUCTURE QUALITY BY ROSETTATITL 2 REFINEMENT: A MOLECULAR REPLACEMENT STUDY.REF PROTEINS V. 75 147 2009REFN ISSN 0887-3585PMID 18816799DOI 10.1002/PROT.22229 Variant Set Distributions Mapped Variants
General Structure Information 3ps4 MAST1 pdz domain from human microtubule-associated serine/threonine-protein kinase 1 1.85Å AUTH E.UGOCHUKWU,J.WANG,T.KROJER,J.R.C.MUNIZ,R.SETHI,A.C.W.PIKE,AUTH 2 A.ROOS,E.SALAH,R.COCKING,P.SAVITSKY,D.A.DOYLE,F.VON DELFT,AUTH 3 C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,S.KNAPP,AUTH 4 J.M.ELKINS,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL PDZ DOMAIN FROM HUMAN MICROTUBULE-ASSOCIATEDTITL 2 SERINE/THREONINE-PROTEIN KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2m9x MAST1 solution nmr structure of microtubule-associated serine/threonine- protein kinase 1 from homo sapiens, northeast structural genomics consortium (nesg) target hr9151a -1.0Å AUTH X.XU,A.ELETSKY,R.SHASTRY,D.LEE,K.HAMILTON,R.XIAO,T.B.ACTON,AUTH 2 J.K.EVERETT,G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF MICROTUBULE-ASSOCIATEDTITL 2 SERINE/THREONINE-PROTEIN KINASE 1 FROM HOMO SAPIENS,TITL 3 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGETTITL 4 HR9151AREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3e77 PSAT1 human phosphoserine aminotransferase in complex with plp 2.5Å AUTH L.LEHTIO,T.KARLBERG,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,M.MOCHE,M.E.NILSSON,P.NORDLUND,T.NYMAN,K.OLESEN,AUTH 5 C.PERSSON,J.SAGEMARK,S.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,J.WEIGELT,AUTH 7 H.SCHUELER,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL HUMAN PHOSPHOSERINE AMINOTRANSFERASE IN COMPLEX WITH PLPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4mvt PIAS3 crystal structure of sumo e3 ligase pias3 2.3Å AUTH J.HU,A.DONG,Y.LI,W.TEMPEL,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONG,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF SUMO E3 LIGASE PIAS3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lna AFG3L2 solution nmr structure of the mitochondrial inner membrane domain (residues 164-251), ftsh_ext, from the paraplegin-like protein afg3l2 from homo sapiens, northeast structural genomics consortium target hr6741a -1.0Å AUTH T.A.RAMELOT,Y.YANG,I.D.SAHU,H.W.LEE,R.XIAO,G.A.LORIGAN,AUTH 2 G.T.MONTELIONE,M.A.KENNEDYTITL NMR STRUCTURE AND MD SIMULATIONS OF THE AAA PROTEASETITL 2 INTERMEMBRANE SPACE DOMAIN INDICATES PERIPHERAL MEMBRANETITL 3 LOCALIZATION WITHIN […]
General Structure Information 2pso STARD13 human stard13 (dlc2) lipid transfer and protein localization domain 2.8Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Mapped Variants
General Structure Information 2jis CSAD human cysteine sulfinic acid decarboxylase (csad) in complex with plp. 1.6Å AUTH R.COLLINS,M.MOCHE,C.ARROWSMITH,H.BERGLUND,R.BUSAM,AUTH 2 L.G.DAHLGREN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,B.M.HALLBERG,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,T.KOTENYOVA,L.LEHTIO,AUTH 5 P.NORDLUND,T.NYMAN,D.OGG,C.PERSSON,J.SAGEMARK,AUTH 6 P.STENMARK,M.SUNDSTROM,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 8 L.HOLMBERG-SCHIAVONETITL THE CRYSTAL STRUCTURE OF HUMAN CYSTEINE SULFINICTITL 2 ACID DECARBOXYLASE (CSAD)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots […]