Assessment of Structural Intolerance and Durability
General Structure Information 2h57 ARL6 crystal structure of human adp-ribosylation factor-like 6 2.0Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,J.LEW,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSYLATIONTITL 2 FACTOR-LIKE 6 (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zd1 SULT4A1 human sulfortransferase sult4a1 2.24Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ovj RACGAP1 the crystal structure of the human rac gtpase activating protein 1 (racgap1) mgcracgap. 1.49Å AUTH L.SHRESTHA,E.PAPAGRIGORIOU,M.SOUNDARARAJAN,J.ELKINS,AUTH 2 C.JOHANSSON,F.VON DELFT,A.C.W.PIKE,N.BURGESS,A.TURNBULL,AUTH 3 J.DEBRECZENI,F.GORREC,C.UMEANO,A.EDWARDS,C.H.ARROWSMITH,AUTH 4 J.WEIGELT,M.SUNDSTROM,D.A.DOYLETITL THE CRYSTAL STRUCTURE OF THE HUMAN RAC GTPASE ACTIVATINGTITL 2 PROTEIN 1 (RACGAP1) MGCRACGAP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lnb ZBP1 solution nmr structure of n-terminal domain (6-74) of human zbp1 protein, northeast structural genomics consortium target hr8174a. -1.0Å AUTH Y.YANG,T.A.RAMELOT,K.HAMILTON,E.KOHAN,D.WANG,T.B.ACTON,AUTH 2 R.XIAO,J.K.EVERETT,G.T.MONTELIONE,M.A.KENNEDYTITL SOLUTION NMR STRUCTURE OF N-TERMINAL DOMAIN (6-74) OF HUMANTITL 2 ZBP1 PROTEIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUMTITL 3 TARGET HR8174AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ag5 BDH2 crystal structure of human dhrs6 1.84Å AUTH K.GUO,P.LUKACIK,E.PAPAGRIGORIOU,M.MEIER,W.H.LEE,J.ADAMSKI,AUTH 2 U.OPPERMANNTITL CHARACTERIZATION OF HUMAN DHRS6, AN ORPHAN SHORT CHAINTITL 2 DEHYDROGENASE/REDUCTASE ENZYME: A NOVEL, CYTOSOLIC TYPE 2TITL 3 R-BETA-HYDROXYBUTYRATE DEHYDROGENASEREF J.BIOL.CHEM. V. 281 10291 2006REFN ISSN 0021-9258PMID 16380372DOI 10.1074/JBC.M511346200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3h8v UBA5 human ubiquitin-activating enzyme 5 in complex with atp 2.0Å AUTH J.P.BACIK,J.R.WALKER,M.ALI,A.D.SCHIMMER,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF THE HUMAN UBIQUITIN-ACTIVATING ENZYME 5TITL 2 (UBA5) BOUND TO ATP: MECHANISTIC INSIGHTS INTO ATITL 3 MINIMALISTIC E1 ENZYME.REF J.BIOL.CHEM. V. 285 20273 2010REFN ISSN 0021-9258PMID 20368332DOI 10.1074/JBC.M110.102921 Variant Set Distributions Mapped Variants
General Structure Information 2b25 TRMT61B human putative trna(1-methyladenosine)methyltransferase 2.5Å AUTH H.WU,W.TEMPEL,A.DONG,H.ZENG,P.LOPPNAU,C.ARROWSMITH,AUTH 2 A.EDWARDS,J.WEIGELT,M.SUNDSTROM,A.BOCHKAREV,A.N.PLOTNIKOVTITL HUMAN PUTATIVE TRNA(1-METHYLADENOSINE)METHYLTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3o4r DHRS4 crystal structure of human dehydrogenase/reductase (sdr family) member 4 (dhrs4) 1.7Å AUTH E.UGOCHUKWU,C.BHATIA,T.KROJER,M.VOLLMAR,W.W.YUE,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN DEHYDROGENASE/REDUCTASE (SDRTITL 2 FAMILY) MEMBER 4 (DHRS4)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3op5 VRK1 human vaccinia-related kinase 1 2.4Å AUTH C.K.ALLERSTON,S.UTTARKAR,P.SAVITSKY,J.M.ELKINS,AUTH 2 P.FILIPPAKOPOULOS,T.KROJER,P.RELLOS,O.FEDOROV,J.ESWARAN,AUTH 3 B.BRENNER,T.KEATES,S.DAS,O.KING,R.CHALK,G.BERRIDGE,AUTH 4 F.VON DELFT,O.GILEADI,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 5 C.BOUNTRA,S.KNAPPTITL HUMAN VACCINIA-RELATED KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2l9r NKX3-1 solution nmr structure of homeobox domain of homeobox protein nkx-3.1 from homo sapiens, northeast structural genomics consortium target hr6470a -1.0Å AUTH G.LIU,R.XIAO,H.-W.LEE,K.HAMILTON,C.CICCOSANTI,H.B.WANG,AUTH 2 T.B.ACTON,J.K.EVERETT,Y.J.HUANG,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF HOMEOBOX DOMAIN OF HOMEOBOXTITL 2 PROTEIN NKX-3.1 FROM HOMO SAPIENS, NORTHEAST STRUCTURALTITL 3 GENOMICS CONSORTIUM TARGET HR6470AREF TO BE PUBLISHEDREFN Variant Set […]