Assessment of Structural Intolerance and Durability
General Structure Information 2r02 PDCD6IP crystal structure of alix/aip1 in complex with the hiv-1 ypltsl late domain 2.6Å AUTH Q.ZHAI,R.D.FISHER,H.Y.CHUNG,D.G.MYSZKA,AUTH 2 W.I.SUNDQUIST,C.P.HILLTITL STRUCTURAL AND FUNCTIONAL STUDIES OF ALIXTITL 2 INTERACTIONS WITH YPX(N)L LATE DOMAINS OF HIV-1TITL 3 AND EIAV.REF NAT.STRUCT.MOL.BIOL. V. 15 43 2008REFN ISSN 1545-9993PMID 18066081DOI 10.1038/NSMB1319 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3sde PSPC1 crystal structure of a paraspeckle-protein heterodimer, pspc1/nono 1.9Å AUTH D.M.PASSON,M.LEE,O.RACKHAM,W.A.STANLEY,A.SADOWSKA,AUTH 2 A.FILIPOVSKA,A.H.FOX,C.S.BONDTITL STRUCTURE OF THE HETERODIMER OF HUMAN NONO AND PARASPECKLETITL 2 PROTEIN COMPONENT 1 AND ANALYSIS OF ITS ROLE IN SUBNUCLEARTITL 3 BODY FORMATION.REF PROC.NATL.ACAD.SCI.USA V. 109 4846 2012REFN ISSN 0027-8424PMID 22416126DOI 10.1073/PNAS.1120792109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2l2l GATAD2A solution structure of the coiled-coil complex between mbd2 and p66alpha -1.0Å AUTH M.N.GNANAPRAGASAM,J.N.SCARSDALE,M.L.AMAYA,H.D.WEBB,AUTH 2 M.A.DESAI,N.M.WALAVALKAR,S.Z.WANG,S.ZU ZHU,G.D.GINDER,AUTH 3 D.C.WILLIAMSTITL P66ALPHA-MBD2 COILED-COIL INTERACTION AND RECRUITMENT OFTITL 2 MI-2 ARE CRITICAL FOR GLOBIN GENE SILENCING BY THE MBD2-NURDTITL 3 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 108 7487 2011REFN ISSN 0027-8424PMID 21490301DOI 10.1073/PNAS.1015341108 Variant Set Distributions Mapped […]
General Structure Information 1vf6 INADL 2.1 angstrom crystal structure of the pals-1-l27n and patj l27 heterodimer complex 2.1Å AUTH Y.LI,D.KARNAK,B.DEMELER,B.MARGOLIS,A.LAVIETITL STRUCTURAL BASIS FOR L27 DOMAIN-MEDIATED ASSEMBLYTITL 2 OF SIGNALING AND CELL POLARITY COMPLEXES.REF EMBO J. V. 23 2723 2004REFN ISSN 0261-4189PMID 15241471DOI 10.1038/SJ.EMBOJ.7600294 Variant Set Distributions Mapped Variants
General Structure Information 4gn1 RAPH1 crystal structure of the ra and ph domains of lamellipodin 2.4Å AUTH Y.C.CHANG,H.ZHANG,M.L.BRENNAN,J.WUTITL CRYSTAL STRUCTURE OF LAMELLIPODIN IMPLICATES DIVERSETITL 2 FUNCTIONS IN ACTIN POLYMERIZATION AND RAS SIGNALING.REF PROTEIN CELL V. 4 211 2013REFN ISSN 1674-800XPMID 23483482DOI 10.1007/S13238-013-2082-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4orh UBE2V2 crystal structure of rnf8 bound to the ubc13/mms2 heterodimer 4.8Å AUTH S.J.CAMPBELL,R.A.EDWARDS,C.C.LEUNG,D.NECULAI,C.D.HODGE,AUTH 2 S.DHE-PAGANON,J.N.GLOVERTITL MOLECULAR INSIGHTS INTO THE FUNCTION OF RING FINGERTITL 2 (RNF)-CONTAINING PROTEINS HRNF8 AND HRNF168 INTITL 3 UBC13/MMS2-DEPENDENT UBIQUITYLATION.REF J.BIOL.CHEM. V. 287 23900 2012REFN ISSN 0021-9258PMID 22589545DOI 10.1074/JBC.M112.359653 Variant Set Distributions Mapped Variants
General Structure Information 3swy CNGA3 cnga3 626-672 containing clz domain 1.9Å AUTH N.G.SHUART,Y.HAITIN,S.S.CAMP,K.D.BLACK,W.N.ZAGOTTATITL MOLECULAR MECHANISM FOR 3:1 SUBUNIT STOICHIOMETRY OF RODTITL 2 CYCLIC NUCLEOTIDE-GATED ION CHANNELS.REF NAT COMMUN V. 2 457 2011REFN ESSN 2041-1723PMID 21878911DOI 10.1038/NCOMMS1466 Variant Set Distributions Mapped Variants
General Structure Information 1s1c ROCK1 crystal structure of the complex between the human rhoa and rho-binding domain of human rocki 2.6Å AUTH R.DVORSKY,L.BLUMENSTEIN,I.R.VETTER,M.R.AHMADIANTITL STRUCTURAL INSIGHTS INTO THE INTERACTION OF ROCKITITL 2 WITH THE SWITCH REGIONS OF RHOA.REF J.BIOL.CHEM. V. 279 7098 2004REFN ISSN 0021-9258PMID 14660612DOI 10.1074/JBC.M311911200 Variant Set Distributions Mapped Variants
General Structure Information 3o0z ROCK1 crystal structure of a coiled-coil domain from human rock i 2.33Å AUTH D.TU,Y.LI,H.K.SONG,A.V.TOMS,C.J.GOULD,S.B.FICARRO,J.A.MARTO,AUTH 2 B.L.GOODE,M.J.ECKTITL CRYSTAL STRUCTURE OF A COILED-COIL DOMAIN FROM HUMAN ROCK I.REF PLOS ONE V. 6 E1808 2011REFN ESSN 1932-6203PMID 21445309DOI 10.1371/JOURNAL.PONE.0018080 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3o0z ROCK1 crystal structure of a coiled-coil domain from human rock i 2.33Å AUTH D.TU,Y.LI,H.K.SONG,A.V.TOMS,C.J.GOULD,S.B.FICARRO,J.A.MARTO,AUTH 2 B.L.GOODE,M.J.ECKTITL CRYSTAL STRUCTURE OF A COILED-COIL DOMAIN FROM HUMAN ROCK I.REF PLOS ONE V. 6 E1808 2011REFN ESSN 1932-6203PMID 21445309DOI 10.1371/JOURNAL.PONE.0018080 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants