Assessment of Structural Intolerance and Durability
General Structure Information 3oai MPZ crystal structure of the extra-cellular domain of human myelin protein zero 2.1Å AUTH Z.LIU,Y.WANG,R.S.YEDIDI,J.S.BRUNZELLE,I.A.KOVARI,J.SOHI,AUTH 2 J.KAMHOLZ,L.C.KOVARITITL CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMANTITL 2 MYELIN PROTEIN ZERO.REF PROTEINS V. 80 307 2012REFN ISSN 0887-3585PMID 21971831DOI 10.1002/PROT.23164 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3nmz APC crytal structure of apc complexed with asef 3.01Å AUTH Z.ZHANG,L.CHEN,L.GAO,K.LIN,G.WUTITL CRYSTAL STRUCTURE OF APC COMPLEXED WITH ASEFREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ezq FAS crystal structure of the fas/fadd death domain complex 2.73Å AUTH F.L.SCOTT,B.STEC,C.POP,M.K.DOBACZEWSKA,J.J.LEE,E.MONOSOV,AUTH 2 H.ROBINSON,G.S.SALVESEN,R.SCHWARZENBACHER,S.J.RIEDLTITL THE FAS-FADD DEATH DOMAIN COMPLEX STRUCTURE UNRAVELSTITL 2 SIGNALLING BY RECEPTOR CLUSTERINGREF NATURE V. 457 1019 2009REFN ISSN 0028-0836PMID 19118384DOI 10.1038/NATURE07606 Variant Set Distributions Mapped Variants
General Structure Information 1z5w TUBG1 crystal structure of gamma-tubulin bound to gtp 3.0Å AUTH H.ALDAZ,L.M.RICE,T.STEARNS,D.A.AGARDTITL INSIGHTS INTO MICROTUBULE NUCLEATION FROM THETITL 2 CRYSTAL STRUCTURE OF HUMAN GAMMA-TUBULIN.REF NATURE V. 435 523 2005REFN ISSN 0028-0836PMID 15917813DOI 10.1038/NATURE03586 Variant Set Distributions Mapped Variants
General Structure Information 2fy5 CHAT structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis 2.6Å AUTH A.R.KIM,R.J.RYLETT,B.H.SHILTONTITL SUBSTRATE BINDING AND CATALYTIC MECHANISM OF HUMANTITL 2 CHOLINE ACETYLTRANSFERASE.REF BIOCHEMISTRY V. 45 14621 2006REFN ISSN 0006-2960PMID 17144655DOI 10.1021/BI061536L Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bic MUT crystal structure of human methylmalonyl-coa mutase 2.6Å AUTH D.S.FROESE,G.KOCHAN,J.R.MUNIZ,X.WU,C.GILEADI,E.UGOCHUKWU,AUTH 2 E.KRYSZTOFINSKA,R.A.GRAVEL,U.OPPERMANN,W.W.YUETITL STRUCTURES OF THE HUMAN GTPASE MMAA AND VITAMINTITL 2 B12-DEPENDENT METHYLMALONYL-COA MUTASE AND INSIGHT INTOTITL 3 THEIR COMPLEX FORMATION.REF J.BIOL.CHEM. V. 285 38204 2010REFN ISSN 0021-9258PMID 20876572DOI 10.1074/JBC.M110.177717 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4l23 PIK3R1 crystal structure of p110alpha complexed with nish2 of p85alpha and pi-103 2.5Å AUTH Y.ZHAO,X.ZHANG,Y.CHEN,S.LU,Y.PENG,X.WANG,C.GUO,A.ZHOU,AUTH 2 J.ZHANG,Y.LUO,Q.SHEN,J.DING,L.MENG,J.ZHANGTITL CRYSTAL STRUCTURES OF PI3K ALPHA COMPLEXED WITH PI103 ANDTITL 2 ITS DERIVATIVES: NEW DIRECTIONS FOR INHIBITORS DESIGN.REF ACS MED CHEM LETT V. 5 138 2014REFN ISSN 1948-5875PMID 24900786DOI 10.1021/ML400378E Variant Set Distributions Ripley’s K […]
General Structure Information 1nf1 NF1 the gap related domain of neurofibromin 2.5Å AUTH K.SCHEFFZEK,M.R.AHMADIAN,L.WIESMULLER,W.KABSCH,AUTH 2 P.STEGE,F.SCHMITZ,A.WITTINGHOFERTITL STRUCTURAL ANALYSIS OF THE GAP-RELATED DOMAIN FROMTITL 2 NEUROFIBROMIN AND ITS IMPLICATIONS.REF EMBO J. V. 17 4313 1998REFN ISSN 0261-4189PMID 9687500DOI 10.1093/EMBOJ/17.15.4313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pvy FGFR2 crystal strucure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k659n mutation responsible for an unclassified craniosynostosis syndrome. 2.2Å AUTH H.CHEN,J.MA,W.LI,A.V.ELISEENKOVA,C.XU,T.A.NEUBERT,AUTH 2 W.T.MILLER,M.MOHAMMADITITL A MOLECULAR BRAKE IN THE KINASE HINGE REGION REGULATES THETITL 2 ACTIVITY OF RECEPTOR TYROSINE KINASES.REF MOL.CELL V. 27 717 2007REFN ISSN 1097-2765PMID 17803937DOI 10.1016/J.MOLCEL.2007.06.028 […]
General Structure Information 1×80 BCKDHB crystal structure of the human mitochondrial branched-chain alpha- ketoacid dehydrogenase 2.0Å AUTH R.M.WYNN,M.KATO,M.MACHIUS,J.L.CHUANG,J.LI,D.R.TOMCHICK,AUTH 2 D.T.CHUANGTITL MOLECULAR MECHANISM FOR REGULATION OF THE HUMANTITL 2 MITOCHONDRIAL BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASETITL 3 COMPLEX BY PHOSPHORYLATIONREF STRUCTURE V. 12 2185 2004REFN ISSN 0969-2126PMID 15576032DOI 10.1016/J.STR.2004.09.013 Variant Set Distributions Mapped Variants