Assessment of Structural Intolerance and Durability
General Structure Information 1k93 CALM3 crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 2.95Å AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1k93 CALM2 crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 2.95Å AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1k93 CALM1 crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 2.95Å AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4my2 NDP crystal structure of norrin in fusion with maltose binding protein 2.4Å AUTH J.KE,K.G.HARIKUMAR,C.ERICE,C.CHEN,X.GU,L.WANG,N.PARKER,AUTH 2 Z.CHENG,W.XU,B.O.WILLIAMS,K.MELCHER,L.J.MILLER,H.E.XUTITL STRUCTURE AND FUNCTION OF NORRIN IN ASSEMBLY AND ACTIVATIONTITL 2 OF A FRIZZLED 4-LRP5/6 COMPLEX.REF GENES DEV. V. 27 2305 2013REFN ISSN 0890-9369PMID 24186977DOI 10.1101/GAD.228544.113 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d9s AQP5 human aquaporin 5 (aqp5) – high resolution x-ray structure 2.0Å AUTH R.HORSEFIELD,K.NORDEN,M.FELLERT,A.BACKMARK,AUTH 2 S.TORNROTH-HORSEFIELD,AUTH 3 A.C.TERWISSCHA VAN SCHELTINGA,J.KVASSMAN,AUTH 4 P.KJELLBOM,U.JOHANSON,R.NEUTZETITL HIGH-RESOLUTION X-RAY STRUCTURE OF HUMAN AQUAPORINTITL 2 5REF PROC.NATL.ACAD.SCI.USA V. 105 13327 2008REFN ISSN 0027-8424PMID 18768791DOI 10.1073/PNAS.0801466105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1tzn ANTXR2 crystal structure of the anthrax toxin protective antigen heptameric prepore bound to the vwa domain of cmg2, an anthrax toxin receptor 4.3Å AUTH D.B.LACY,D.J.WIGELSWORTH,R.A.MELNYK,S.C.HARRISON,R.J.COLLIERTITL STRUCTURE OF HEPTAMERIC PROTECTIVE ANTIGEN BOUND TO ANTITL 2 ANTHRAX TOXIN RECEPTOR: A ROLE FOR RECEPTOR IN PH-DEPENDENTTITL 3 PORE FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 101 13147 2004REFN […]
General Structure Information 3lhm LYZ crystal structures of the apo-and holomutant human lysozymes with an introduced ca2+ binding site 1.8Å AUTH K.INAKA,R.KUROKI,M.KIKUCHI,M.MATSUSHIMATITL CRYSTAL STRUCTURES OF THE APO- AND HOLOMUTANTTITL 2 HUMAN LYSOZYMES WITH AN INTRODUCED CA2+ BINDINGTITL 3 SITE.REF J.BIOL.CHEM. V. 266 20666 1991REFN ISSN 0021-9258PMID 1939116 Variant Set Distributions Mapped Variants
General Structure Information 2fdb FGF8 crystal structure of fibroblast growth factor (fgf)8b in complex with fgf receptor (fgfr) 2c 2.28Å AUTH S.K.OLSEN,J.Y.H.LI,C.BROMLEIGH,A.V.ELISEENKOVA,AUTH 2 O.A.IBRAHIMI,Z.LAO,F.ZHANG,R.J.LINHARDT,A.L.JOYNER,AUTH 3 M.MOHAMMADITITL STRUCTURAL BASIS BY WHICH ALTERNATIVE SPLICINGTITL 2 MODULATES THE ORGANIZER ACTIVITY OF FGF8 IN THETITL 3 BRAINREF GENES DEV. V. 20 185 2006REFN ISSN 0890-9369PMID 16384934DOI 10.1101/GAD.1365406 Variant Set […]
General Structure Information 3efh PRPS1 crystal structure of human phosphoribosyl pyrophosphate synthetase 1 2.6Å AUTH X.PENG,X.LITITL CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYLTITL 2 PYROPHOSPHATE SYNTHETASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hu2 VCP structure of p97 n-d1 r86a mutant in complex with atpgs 2.85Å AUTH W.K.TANG,D.LI,C.C.LI,L.ESSER,R.DAI,L.GUO,D.XIATITL A NOVEL ATP-DEPENDENT CONFORMATION IN P97 N-D1 FRAGMENTTITL 2 REVEALED BY CRYSTAL STRUCTURES OF DISEASE-RELATED MUTANTS.REF EMBO J. V. 29 2217 2010REFN ISSN 0261-4189PMID 20512113DOI 10.1038/EMBOJ.2010.104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]