Assessment of Structural Intolerance and Durability
General Structure Information 2r3v MVK the biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism 2.5Å AUTH Z.FU,N.E.VOYNOVA,T.J.HERDENDORF,H.M.MIZIORKO,AUTH 2 J.J.KIMTITL BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACKTITL 2 INHIBITION OF MEVALONATE KINASE AND ISOPRENOIDTITL 3 METABOLISM.REF BIOCHEMISTRY V. 47 3715 2008REFN ISSN 0006-2960PMID 18302342DOI 10.1021/BI7024386 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3w7r DHODH structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 1.68Å AUTH D.K.INAOKA,M.IIDA,T.TABUCHI,N.LEE,S.HASHIMOTO,S.MATSUOKA,AUTH 2 T.KURANAGA,T.SHIBA,K.SAKAMOTO,S.SUZUKI,E.O.BALOGUN,T.NARA,AUTH 3 T.AOKI,M.INOUE,T.HONMA,A.TANAKA,S.HARADA,K.KITATITL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEXTITL 2 WITH MII-4-097REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3w7r DHODH structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 1.68Å AUTH D.K.INAOKA,M.IIDA,T.TABUCHI,N.LEE,S.HASHIMOTO,S.MATSUOKA,AUTH 2 T.KURANAGA,T.SHIBA,K.SAKAMOTO,S.SUZUKI,E.O.BALOGUN,T.NARA,AUTH 3 T.AOKI,M.INOUE,T.HONMA,A.TANAKA,S.HARADA,K.KITATITL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEXTITL 2 WITH MII-4-097REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3w7r DHODH structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 1.68Å AUTH D.K.INAOKA,M.IIDA,T.TABUCHI,N.LEE,S.HASHIMOTO,S.MATSUOKA,AUTH 2 T.KURANAGA,T.SHIBA,K.SAKAMOTO,S.SUZUKI,E.O.BALOGUN,T.NARA,AUTH 3 T.AOKI,M.INOUE,T.HONMA,A.TANAKA,S.HARADA,K.KITATITL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEXTITL 2 WITH MII-4-097REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4a11 ERCC8 structure of the hsddb1-hscsa complex 3.31Å AUTH E.S.FISCHER,A.SCRIMA,K.BOHM,S.MATSUMOTO,G.M.LINGARAJU,AUTH 2 M.FATY,T.YASUDA,S.CAVADINI,M.WAKASUGI,F.HANAOKA,S.IWAI,AUTH 3 H.GUT,K.SUGASAWA,N.H.THOMATITL THE MOLECULAR BASIS OF CRL4(DDB2/CSA) UBIQUITIN LIGASETITL 2 ARCHITECTURE, TARGETING, AND ACTIVATION.REF CELL(CAMBRIDGE,MASS.) V. 147 1024 2011REFN ISSN 0092-8674PMID 22118460DOI 10.1016/J.CELL.2011.10.035 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1fvr TEK tie2 kinase domain 2.2Å AUTH L.M.SHEWCHUK,A.M.HASSELL,B.ELLIS,W.D.HOLMES,AUTH 2 R.DAVIS,E.L.HORNE,S.H.KADWELL,D.D.MCKEE,J.T.MOORETITL STRUCTURE OF THE TIE2 RTK DOMAIN: SELF-INHIBITIONTITL 2 BY THE NUCLEOTIDE BINDING LOOP, ACTIVATION LOOP,TITL 3 AND C-TERMINAL TAIL.REF STRUCTURE FOLD.DES. V. 8 1105 2000REFN ISSN 0969-2126PMID 11080633DOI 10.1016/S0969-2126(00)00516-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4bgg ACVR1 crystal structure of the acvr1 kinase in complex with ldn-213844 2.56Å AUTH A.H.MOHEDAS,Y.WANG,C.E.SANVITALE,P.CANNING,S.CHOI,X.XING,AUTH 2 A.N.BULLOCK,G.D.CUNY,P.B.YUTITL STRUCTURE-ACTIVITY RELATIONSHIP OF 3,5-DIARYL-2-TITL 2 AMINOPYRIDINE ALK2 INHIBITORS REVEALS UNALTERED BINDINGTITL 3 AFFINITY FOR FIBRODYSPLASIA OSSIFICANS PROGRESSIVA CAUSINGTITL 4 MUTANTS.REF J.MED.CHEM. V. 57 7900 2014REFN ISSN 0022-2623PMID 25101911DOI 10.1021/JM501177W Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1q9c SOS1 crystal structure of the histone domain of son of sevenless 3.21Å AUTH H.SONDERMANN,S.M.SOISSON,D.BAR-SAGI,J.KURIYANTITL TANDEM HISTONE FOLDS IN THE STRUCTURE OF THETITL 2 N-TERMINAL SEGMENT OF THE RAS ACTIVATOR SON OFTITL 3 SEVENLESSREF STRUCTURE V. 11 1583 2003REFN ISSN 0969-2126PMID 14656442DOI 10.1016/J.STR.2003.10.015 Variant Set Distributions Mapped Variants
General Structure Information 2qyn PDE4D crystal structure of pde4d2 in complex with inhibitor npv 1.57Å AUTH H.WANG,M.S.PENG,Y.CHEN,J.GENG,H.ROBINSON,AUTH 2 M.D.HOUSLAY,J.CAI,H.KETITL STRUCTURES OF THE FOUR SUBFAMILIES OFTITL 2 PHOSPHODIESTERASE-4 PROVIDE INSIGHT INTO THETITL 3 SELECTIVITY OF THEIR INHIBITORS.REF BIOCHEM.J. V. 408 193 2007REFN ISSN 0264-6021PMID 17727341DOI 10.1042/BJ20070970 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1xdv SOS1 experimentally phased structure of human the son of sevenless protein at 4.1 ang. 4.1Å AUTH H.SONDERMANN,S.M.SOISSON,S.BOYKEVISCH,S.S.YANG,AUTH 2 D.BAR-SAGI,J.KURIYANTITL STRUCTURAL ANALYSIS OF AUTOINHIBITION IN THE RASTITL 2 ACTIVATOR SON OF SEVENLESS.REF CELL(CAMBRIDGE,MASS.) V. 119 393 2004REFN ISSN 0092-8674PMID 15507210DOI 10.1016/J.CELL.2004.10.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]