Assessment of Structural Intolerance and Durability
General Structure Information 2kum CCL27 solution structure of the human chemokine ccl27 -1.0Å AUTH A.L.JANSMA,J.P.KIRKPATRICK,A.R.HSU,T.M.HANDEL,D.NIETLISPACHTITL NMR ANALYSIS OF THE STRUCTURE, DYNAMICS, AND UNIQUETITL 2 OLIGOMERIZATION PROPERTIES OF THE CHEMOKINE CCL27.REF J.BIOL.CHEM. V. 285 14424 2010REFN ISSN 0021-9258PMID 20200157DOI 10.1074/JBC.M109.091108 Variant Set Distributions Mapped Variants
General Structure Information 2ra4 CCL13 crystal structure of human monocyte chemoattractant protein 4 (mcp- 4/ccl13) 1.7Å AUTH C.BARINKA,A.PRAHL,J.LUBKOWSKITITL STRUCTURE OF HUMAN MONOCYTE CHEMOATTRACTANT PROTEIN 4TITL 2 (MCP-4/CCL13).REF ACTA CRYSTALLOGR.,SECT.D V. 64 273 2008REFN ISSN 0907-4449PMID 18323622DOI 10.1107/S0907444907066164 Variant Set Distributions Mapped Variants
General Structure Information 1nr4 CCL17 high resolution crystal structures of thymus and activation- regulated chemokine 1.72Å AUTH O.A.ASOJO,C.BOULEGUE,D.M.HOOVER,W.LU,J.LUBKOWSKITITL STRUCTURES OF THYMUS AND ACTIVATION-REGULATEDTITL 2 CHEMOKINE (TARC).REF ACTA CRYSTALLOGR.,SECT.D V. 59 1165 2003REFN ISSN 0907-4449PMID 12832759DOI 10.1107/S0907444903009454 Variant Set Distributions Mapped Variants
General Structure Information 1esr CCL8 crystal structure of human monocyte chemotactic protein-2 2.0Å AUTH J.BLASZCZYK,E.V.COILLIE,P.PROOST,J.V.DAMME,AUTH 2 G.OPDENAKKER,G.D.BUJACZ,J.M.WANG,X.JITITL COMPLETE CRYSTAL STRUCTURE OF MONOCYTE CHEMOTACTICTITL 2 PROTEIN-2, A CC CHEMOKINE THAT INTERACTS WITHTITL 3 MULTIPLE RECEPTORS.REF BIOCHEMISTRY V. 39 14075 2000REFN ISSN 0006-2960PMID 11087354DOI 10.1021/BI0009340 Variant Set Distributions Mapped Variants
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]
General Structure Information 1esr CCL8 crystal structure of human monocyte chemotactic protein-2 2.0Å AUTH J.BLASZCZYK,E.V.COILLIE,P.PROOST,J.V.DAMME,AUTH 2 G.OPDENAKKER,G.D.BUJACZ,J.M.WANG,X.JITITL COMPLETE CRYSTAL STRUCTURE OF MONOCYTE CHEMOTACTICTITL 2 PROTEIN-2, A CC CHEMOKINE THAT INTERACTS WITHTITL 3 MULTIPLE RECEPTORS.REF BIOCHEMISTRY V. 39 14075 2000REFN ISSN 0006-2960PMID 11087354DOI 10.1021/BI0009340 Variant Set Distributions Mapped Variants
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]
General Structure Information 1eot CCL11 solution nmr structure of eotaxin, minimized average structure -1.0Å AUTH M.P.CRUMP,K.RAJARATHNAM,K.S.KIM,I.CLARK-LEWIS,AUTH 2 B.D.SYKESTITL SOLUTION STRUCTURE OF EOTAXIN, A CHEMOKINE THATTITL 2 SELECTIVELY RECRUITS EOSINOPHILS IN ALLERGICTITL 3 INFLAMMATION.REF J.BIOL.CHEM. V. 273 22471 1998REFN ISSN 0021-9258PMID 9712872DOI 10.1074/JBC.273.35.22471 Variant Set Distributions Mapped Variants
General Structure Information 4mbs CCR5 crystal structure of the ccr5 chemokine receptor 2.71Å AUTH Q.TAN,Y.ZHU,J.LI,Z.CHEN,G.W.HAN,I.KUFAREVA,T.LI,L.MA,AUTH 2 G.FENALTI,J.LI,W.ZHANG,X.XIE,H.YANG,H.JIANG,V.CHEREZOV,AUTH 3 H.LIU,R.C.STEVENS,Q.ZHAO,B.WUTITL STRUCTURE OF THE CCR5 CHEMOKINE RECEPTOR-HIV ENTRY INHIBITORTITL 2 MARAVIROC COMPLEX.REF SCIENCE V. 341 1387 2013REFN ISSN 0036-8075PMID 24030490DOI 10.1126/SCIENCE.1241475 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1j8i XCL1 solution structure of human lymphotactin -1.0Å AUTH E.S.KULOGLU,D.R.MCCASLIN,M.KITABWALLA,C.D.PAUZA,AUTH 2 J.L.MARKLEY,B.F.VOLKMANTITL MONOMERIC SOLUTION STRUCTURE OF THE PROTOTYPICALTITL 2 C CHEMOKINE LYMPHOTACTIN.REF BIOCHEMISTRY V. 40 12486 2001REFN ISSN 0006-2960PMID 11601972DOI 10.1021/BI011106P Variant Set Distributions Mapped Variants