Assessment of Structural Intolerance and Durability
General Structure Information 2l4r KCNH2 nmr solution structure of the n-terminal pas domain of herg -1.0Å AUTH Q.LI,S.GAYEN,A.S.CHEN,Q.HUANG,M.RAIDA,C.KANGTITL NMR SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF HERG ANDTITL 2 ITS INTERACTION WITH THE S4-S5 LINKER.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 403 126 2010REFN ISSN 0006-291XPMID 21055387DOI 10.1016/J.BBRC.2010.10.132 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zsx KCNAB2 crystal structure of human potassium channel kv beta-subunit (kcnab2) 1.9Å AUTH P.WENNERSTRAND,I.JOHANNSSON,E.UGOCHUKWU,K.KAVANAGH,AUTH 2 A.EDWARDS,C.ARROWSMITH,L.WILLIAMS,M.SUNDSTROM,K.GUO,AUTH 3 F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNITTITL 2 (KCNAB2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3naf KCNMA1 structure of the intracellular gating ring from the human high- conductance ca2+ gated k+ channel (bk channel) 3.1Å AUTH Y.WU,Y.YANG,S.YE,Y.JIANGTITL STRUCTURE OF THE GATING RING FROM THE HUMANTITL 2 LARGE-CONDUCTANCE CA(2+)-GATED K(+) CHANNEL.REF NATURE V. 466 393 2010REFN ISSN 0028-0836PMID 20574420DOI 10.1038/NATURE09252 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ymk DCD crystal structure of the hexameric anti-microbial peptide channel dermcidin 2.49Å AUTH C.SONG,C.WEICHBRODT,E.S.SALNIKOV,M.DYNOWSKI,B.O.FORSBERG,AUTH 2 B.BECHINGER,C.STEINEM,B.L.DE GROOT,U.ZACHARIAE,K.ZETHTITL CRYSTAL STRUCTURE AND FUNCTIONAL MECHANISM OF A HUMANTITL 2 ANTIMICROBIAL MEMBRANE CHANNEL.REF PROC.NATL.ACAD.SCI.USA V. 110 4586 2013REFN ISSN 0027-8424PMID 23426625DOI 10.1073/PNAS.1214739110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3d9s AQP5 human aquaporin 5 (aqp5) – high resolution x-ray structure 2.0Å AUTH R.HORSEFIELD,K.NORDEN,M.FELLERT,A.BACKMARK,AUTH 2 S.TORNROTH-HORSEFIELD,AUTH 3 A.C.TERWISSCHA VAN SCHELTINGA,J.KVASSMAN,AUTH 4 P.KJELLBOM,U.JOHANSON,R.NEUTZETITL HIGH-RESOLUTION X-RAY STRUCTURE OF HUMAN AQUAPORINTITL 2 5REF PROC.NATL.ACAD.SCI.USA V. 105 13327 2008REFN ISSN 0027-8424PMID 18768791DOI 10.1073/PNAS.0801466105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2ovc KCNQ4 crystal structure of a coiled-coil tetramerization domain from kv7.4 channels 2.07Å AUTH R.J.HOWARD,K.A.CLARK,J.M.HOLTON,D.L.MINORTITL STRUCTURAL INSIGHT INTO KCNQ (KV7) CHANNEL ASSEMBLY ANDTITL 2 CHANNELOPATHY.REF NEURON V. 53 663 2007REFN ISSN 0896-6273PMID 17329207DOI 10.1016/J.NEURON.2007.02.010 Variant Set Distributions Mapped Variants
General Structure Information 4kfm GNB1 crystal structure of the g protein-gated inward rectifier k+ channel girk2 (kir3.2) in complex with the beta-gamma g protein subunits 3.45Å AUTH M.R.WHORTON,R.MACKINNONTITL X-RAY STRUCTURE OF THE MAMMALIAN GIRK2-BETA GAMMA G-PROTEINTITL 2 COMPLEX.REF NATURE V. 498 190 2013REFN ISSN 0028-0836PMID 23739333DOI 10.1038/NATURE12241 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4kfm GNG2 crystal structure of the g protein-gated inward rectifier k+ channel girk2 (kir3.2) in complex with the beta-gamma g protein subunits 3.45Å AUTH M.R.WHORTON,R.MACKINNONTITL X-RAY STRUCTURE OF THE MAMMALIAN GIRK2-BETA GAMMA G-PROTEINTITL 2 COMPLEX.REF NATURE V. 498 190 2013REFN ISSN 0028-0836PMID 23739333DOI 10.1038/NATURE12241 Variant Set Distributions Mapped Variants
General Structure Information 2o36 THOP1 crystal structure of engineered thimet oligopeptidase with neurolysin specificity in neurotensin cleavage site 1.95Å AUTH E.J.LIM,S.SAMPATH,J.COLL-RODRIGUEZ,J.SCHMIDT,K.RAY,AUTH 2 D.W.RODGERSTITL SWAPPING THE SUBSTRATE SPECIFICITIES OF THETITL 2 NEUROPEPTIDASES NEUROLYSIN AND THIMETTITL 3 OLIGOPEPTIDASE.REF J.BIOL.CHEM. V. 282 9722 2007REFN ISSN 0021-9258PMID 17251185DOI 10.1074/JBC.M609897200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2ja3 CLCN5 cytoplasmic domain of the human chloride transporter clc-5 in complex with adp 3.05Å AUTH S.MEYER,S.SAVARESI,I.C.FORSTER,R.DUTZLERTITL NUCLEOTIDE RECOGNITION BY THE CYTOPLASMIC DOMAINTITL 2 OF THE HUMAN CHLORIDE TRANSPORTER CLC-5REF NAT.STRUCT.MOL.BIOL. V. 14 60 2006REFN ISSN 1545-9993PMID 17195847DOI 10.1038/NSMB1188 Variant Set Distributions Mapped Variants