Assessment of Structural Intolerance and Durability
General Structure Information 3oxq CACNA1C crystal structure of ca2+/cam-cav1.2 pre-iq/iq domain complex 2.55Å AUTH E.Y.KIM,C.H.RUMPF,F.VAN PETEGEM,R.J.ARANT,F.FINDEISEN,AUTH 2 E.S.COOLEY,E.Y.ISACOFF,D.L.MINORTITL MULTIPLE C-TERMINAL TAIL CA(2+)/CAMS REGULATE CA(V)1.2TITL 2 FUNCTION BUT DO NOT MEDIATE CHANNEL DIMERIZATION.REF EMBO J. V. 29 3924 2010REFN ISSN 0261-4189PMID 20953164DOI 10.1038/EMBOJ.2010.260 Variant Set Distributions Mapped Variants
General Structure Information 3hrn PKD2 crystal structure of a c-terminal coiled coil domain of transient receptor potential (trp) channel subfamily p member 2 (trpp2, polycystic kidney disease 2) 1.9Å AUTH Y.YU,M.H.ULBRICH,M.H.LI,Z.BURAEI,X.Z.CHEN,A.C.ONG,AUTH 2 L.TONG,E.Y.ISACOFF,J.YANGTITL STRUCTURAL AND MOLECULAR BASIS OF THE ASSEMBLY OFTITL 2 THE TRPP2/PKD1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 106 11558 2009REFN ISSN 0027-8424PMID 19556541DOI 10.1073/PNAS.0903684106 Variant […]
General Structure Information 4dck SCN5A crystal structure of the c-terminus of voltage-gated sodium channel in complex with fgf13 and cam 2.2Å AUTH C.WANG,B.C.CHUNG,H.YAN,S.Y.LEE,G.S.PITTTITL CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF A NAV C-TERMINALTITL 2 DOMAIN, A FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR, ANDTITL 3 CALMODULIN.REF STRUCTURE V. 20 1167 2012REFN ISSN 0969-2126PMID 22705208DOI 10.1016/J.STR.2012.05.001 Variant Set […]
General Structure Information 4dck SCN5A crystal structure of the c-terminus of voltage-gated sodium channel in complex with fgf13 and cam 2.2Å AUTH C.WANG,B.C.CHUNG,H.YAN,S.Y.LEE,G.S.PITTTITL CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF A NAV C-TERMINALTITL 2 DOMAIN, A FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR, ANDTITL 3 CALMODULIN.REF STRUCTURE V. 20 1167 2012REFN ISSN 0969-2126PMID 22705208DOI 10.1016/J.STR.2012.05.001 Variant Set […]
General Structure Information 4dck SCN5A crystal structure of the c-terminus of voltage-gated sodium channel in complex with fgf13 and cam 2.2Å AUTH C.WANG,B.C.CHUNG,H.YAN,S.Y.LEE,G.S.PITTTITL CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF A NAV C-TERMINALTITL 2 DOMAIN, A FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR, ANDTITL 3 CALMODULIN.REF STRUCTURE V. 20 1167 2012REFN ISSN 0969-2126PMID 22705208DOI 10.1016/J.STR.2012.05.001 Variant Set […]
General Structure Information 2l4r KCNH2 nmr solution structure of the n-terminal pas domain of herg -1.0Å AUTH Q.LI,S.GAYEN,A.S.CHEN,Q.HUANG,M.RAIDA,C.KANGTITL NMR SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF HERG ANDTITL 2 ITS INTERACTION WITH THE S4-S5 LINKER.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 403 126 2010REFN ISSN 0006-291XPMID 21055387DOI 10.1016/J.BBRC.2010.10.132 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zsx KCNAB2 crystal structure of human potassium channel kv beta-subunit (kcnab2) 1.9Å AUTH P.WENNERSTRAND,I.JOHANNSSON,E.UGOCHUKWU,K.KAVANAGH,AUTH 2 A.EDWARDS,C.ARROWSMITH,L.WILLIAMS,M.SUNDSTROM,K.GUO,AUTH 3 F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNITTITL 2 (KCNAB2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3naf KCNMA1 structure of the intracellular gating ring from the human high- conductance ca2+ gated k+ channel (bk channel) 3.1Å AUTH Y.WU,Y.YANG,S.YE,Y.JIANGTITL STRUCTURE OF THE GATING RING FROM THE HUMANTITL 2 LARGE-CONDUCTANCE CA(2+)-GATED K(+) CHANNEL.REF NATURE V. 466 393 2010REFN ISSN 0028-0836PMID 20574420DOI 10.1038/NATURE09252 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ymk DCD crystal structure of the hexameric anti-microbial peptide channel dermcidin 2.49Å AUTH C.SONG,C.WEICHBRODT,E.S.SALNIKOV,M.DYNOWSKI,B.O.FORSBERG,AUTH 2 B.BECHINGER,C.STEINEM,B.L.DE GROOT,U.ZACHARIAE,K.ZETHTITL CRYSTAL STRUCTURE AND FUNCTIONAL MECHANISM OF A HUMANTITL 2 ANTIMICROBIAL MEMBRANE CHANNEL.REF PROC.NATL.ACAD.SCI.USA V. 110 4586 2013REFN ISSN 0027-8424PMID 23426625DOI 10.1073/PNAS.1214739110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3d9s AQP5 human aquaporin 5 (aqp5) – high resolution x-ray structure 2.0Å AUTH R.HORSEFIELD,K.NORDEN,M.FELLERT,A.BACKMARK,AUTH 2 S.TORNROTH-HORSEFIELD,AUTH 3 A.C.TERWISSCHA VAN SCHELTINGA,J.KVASSMAN,AUTH 4 P.KJELLBOM,U.JOHANSON,R.NEUTZETITL HIGH-RESOLUTION X-RAY STRUCTURE OF HUMAN AQUAPORINTITL 2 5REF PROC.NATL.ACAD.SCI.USA V. 105 13327 2008REFN ISSN 0027-8424PMID 18768791DOI 10.1073/PNAS.0801466105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]