Assessment of Structural Intolerance and Durability
General Structure Information 3ii6 XRCC4 structure of human xrcc4 in complex with the tandem brct domains of dna ligaseiv. 2.4Å AUTH P.Y.WU,P.FRIT,S.MEESALA,S.DAUVILLIER,M.MODESTI,AUTH 2 S.N.ANDRES,Y.HUANG,J.SEKIGUCHI,P.CALSOU,B.SALLES,AUTH 3 M.S.JUNOPTITL STRUCTURAL AND FUNCTIONAL INTERACTION BETWEEN THETITL 2 HUMAN DNA REPAIR PROTEINS DNA LIGASE IV AND XRCC4REF MOL.CELL.BIOL. V. 11 3163 2009REFN ISSN 0270-7306PMID 19332554 Variant Set Distributions Mapped Variants
General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rii PRDX1 crystal structure of human peroxiredoxin i in complex with sulfiredoxin 2.6Å AUTH T.J.JONSSON,L.C.JOHNSON,W.T.LOWTHERTITL STRUCTURE OF THE SULPHIREDOXIN-PEROXIREDOXIN COMPLEX REVEALSTITL 2 AN ESSENTIAL REPAIR EMBRACE.REF NATURE V. 451 98 2008REFN ISSN 0028-0836PMID 18172504DOI 10.1038/NATURE06415 Variant Set Distributions Mapped Variants
General Structure Information 3k9p UBE2K the crystal structure of e2-25k and ubiquitin complex 2.8Å AUTH S.KO,G.B.KANG,S.M.SONG,J.-G.LEE,D.Y.SHIN,J.-H.YUN,Y.SHENG,AUTH 2 C.CHEONG,Y.H.JEON,Y.-K.JUNG,C.H.ARROWSMITH,G.V.AVVAKUMOV,AUTH 3 S.DHE-PAGANON,Y.J.YOO,S.H.EOM,W.LEETITL STRUCTURAL BASIS OF E2-25K/UBB+1 INTERACTION LEADING TOTITL 2 PROTEASOME INHIBITION AND NEUROTOXICITYREF J.BIOL.CHEM. V. 285 36070 2010REFN ISSN 0021-9258PMID 20826778DOI 10.1074/JBC.M110.145219 Variant Set Distributions Mapped Variants
General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rii PRDX1 crystal structure of human peroxiredoxin i in complex with sulfiredoxin 2.6Å AUTH T.J.JONSSON,L.C.JOHNSON,W.T.LOWTHERTITL STRUCTURE OF THE SULPHIREDOXIN-PEROXIREDOXIN COMPLEX REVEALSTITL 2 AN ESSENTIAL REPAIR EMBRACE.REF NATURE V. 451 98 2008REFN ISSN 0028-0836PMID 18172504DOI 10.1038/NATURE06415 Variant Set Distributions Mapped Variants
General Structure Information 3k9p UBE2K the crystal structure of e2-25k and ubiquitin complex 2.8Å AUTH S.KO,G.B.KANG,S.M.SONG,J.-G.LEE,D.Y.SHIN,J.-H.YUN,Y.SHENG,AUTH 2 C.CHEONG,Y.H.JEON,Y.-K.JUNG,C.H.ARROWSMITH,G.V.AVVAKUMOV,AUTH 3 S.DHE-PAGANON,Y.J.YOO,S.H.EOM,W.LEETITL STRUCTURAL BASIS OF E2-25K/UBB+1 INTERACTION LEADING TOTITL 2 PROTEASOME INHIBITION AND NEUROTOXICITYREF J.BIOL.CHEM. V. 285 36070 2010REFN ISSN 0021-9258PMID 20826778DOI 10.1074/JBC.M110.145219 Variant Set Distributions Mapped Variants
General Structure Information 3jts B2M gy9-mamu-a*02-hb2m 2.8Å AUTH L.DAITITL STRUCTURE OF MAMU A*2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wng SIRPA complete extracellular structure of human signal regulatory protein (sirp) alpha 2.49Å AUTH D.HATHERLEY,S.C.GRAHAM,K.HARLOS,D.I.STUART,AUTH 2 A.N.BARCLAYTITL STRUCTURE OF SIGNAL-REGULATORY PROTEIN ALPHA: ATITL 2 LINK TO ANTIGEN RECEPTOR EVOLUTION.REF J.BIOL.CHEM. V. 284 26613 2009REFN ISSN 0021-9258PMID 19628875DOI 10.1074/JBC.M109.017566 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3h95 NUDT6 crystal structure of the nudix domain of nudt6 1.7Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTYENOVA,A.KOTZCH,T.K.NIELSEN,T.NYMAN,C.PERSSON,AUTH 5 J.SAGEMARK,H.SCHUELER,P.SCHUTZ,M.I.SIPONEN,L.SVENSSON,AUTH 6 A.G.THORSELL,S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE NUDIX DOMAIN OF NUDT6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants