Assessment of Structural Intolerance and Durability
General Structure Information 2kum CCL27 solution structure of the human chemokine ccl27 -1.0Å AUTH A.L.JANSMA,J.P.KIRKPATRICK,A.R.HSU,T.M.HANDEL,D.NIETLISPACHTITL NMR ANALYSIS OF THE STRUCTURE, DYNAMICS, AND UNIQUETITL 2 OLIGOMERIZATION PROPERTIES OF THE CHEMOKINE CCL27.REF J.BIOL.CHEM. V. 285 14424 2010REFN ISSN 0021-9258PMID 20200157DOI 10.1074/JBC.M109.091108 Variant Set Distributions Mapped Variants
General Structure Information 3k0w MALT1 crystal structure of the tandem ig-like c2-type 2 domains of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1 2.8Å AUTH J.R.WALKER,L.QIU,C.BUTLER-COLE,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL STRUCTURE OF THE TANDEM IG-LIKE C2-TYPE 2 DOMAINSTITL 2 OF THE HUMAN MUCOSA-ASSOCIATED LYMPHOID TISSUETITL 3 LYMPHOMA TRANSLOCATION PROTEIN 1.REF TO BE PUBLISHEDREFN Variant […]
General Structure Information 3jtc PROCR importance of mg2+ in the ca2+-dependent folding of the gamma- carboxyglutamic acid domains of vitamin k-dependent clotting and anticlotting proteins 1.6Å AUTH K.VADIVEL,S.AGAH,A.S.MESSER,D.CASCIO,M.S.BAJAJ,AUTH 2 S.KRISHNASWAMY,C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL STRUCTURAL AND FUNCTIONAL STUDIES OF GAMMA-CARBOXYGLUTAMICTITL 2 ACID DOMAINS OF FACTOR VIIA AND ACTIVATED PROTEIN C: ROLE OFTITL 3 MAGNESIUM AT PHYSIOLOGICAL CALCIUM.REF J.MOL.BIOL. V. […]
General Structure Information 3i3t USP21 crystal structure of covalent ubiquitin-usp21 complex 2.59Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2l0f POLI solution nmr structure of human polymerase iota ubm2 (p692a mutant) in complex with ubiquitin -1.0Å AUTH G.CUI,R.C.BENIRSCHKE,H.F.TUAN,N.JURANIC,S.MACURA,AUTH 2 M.V.BOTUYAN,G.MERTITL STRUCTURAL BASIS OF UBIQUITIN RECOGNITION BY TRANSLESIONTITL 2 SYNTHESIS DNA POLYMERASE IOTA.REF BIOCHEMISTRY V. 49 10198 2010REFN ISSN 0006-2960PMID 21049971DOI 10.1021/BI101303T Variant Set Distributions Mapped Variants
General Structure Information 3h5c SERPINA10 x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3a6p XPO5 crystal structure of exportin-5:rangtp:pre-mirna complex 2.92Å AUTH C.OKADA,E.YAMASHITA,S.J.LEE,S.SHIBATA,J.KATAHIRA,A.NAKAGAWA,AUTH 2 Y.YONEDA,T.TSUKIHARATITL A HIGH-RESOLUTION STRUCTURE OF THE PRE-MICRORNA NUCLEARTITL 2 EXPORT MACHINERYREF SCIENCE V. 326 1275 2009REFN ISSN 0036-8075PMID 19965479DOI 10.1126/SCIENCE.1178705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4gdk ATG5 crystal structure of human atg12~atg5 conjugate in complex with an n- terminal fragment of atg16l1 2.7Å AUTH C.OTOMO,Z.METLAGEL,G.TAKAESU,T.OTOMOTITL STRUCTURE OF THE HUMAN ATG12~ATG5 CONJUGATE REQUIRED FOR LC3TITL 2 LIPIDATION IN AUTOPHAGY.REF NAT.STRUCT.MOL.BIOL. V. 20 59 2013REFN ISSN 1545-9993PMID 23202584DOI 10.1038/NSMB.2431 Variant Set Distributions Mapped Variants
General Structure Information 2yra SEZ6L solution structure of the zinc finger domains (1-87) from human f-box only protein -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZINC FINGER DOMAINSTITL 2 (1-87) FROM HUMAN F-BOX ONLY PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wft HHIP crystal structure of the human hip ectodomain 2.8Å AUTH B.BISHOP,A.R.ARICESCU,K.HARLOS,C.A.OCALLAGHAN,AUTH 2 E.Y.JONES,C.SIEBOLDTITL STRUCTURAL INSIGHTS INTO HEDGEHOG LIGANDTITL 2 SEQUESTRATION BY THE HUMAN HEDGEHOG-INTERACTINGTITL 3 PROTEIN HIPREF NAT.STRUCT.MOL.BIOL. V. 16 698 2009REFN ISSN 1545-9993PMID 19561611DOI 10.1038/NSMB.1607 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants