Assessment of Structural Intolerance and Durability
General Structure Information 3f8u PDIA3 tapasin/erp57 heterodimer 2.6Å AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018 Variant Set Distributions Mapped Variants
General Structure Information 1jey XRCC5 crystal structure of the ku heterodimer bound to dna 2.5Å AUTH J.R.WALKER,R.A.CORPINA,J.GOLDBERGTITL STRUCTURE OF THE KU HETERODIMER BOUND TO DNA ANDTITL 2 ITS IMPLICATIONS FOR DOUBLE-STRAND BREAK REPAIR.REF NATURE V. 412 607 2001REFN ISSN 0028-0836PMID 11493912DOI 10.1038/35088000 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1jeq XRCC6 crystal structure of the ku heterodimer 2.7Å AUTH J.R.WALKER,R.A.CORPINA,J.GOLDBERGTITL STRUCTURE OF THE KU HETERODIMER BOUND TO DNA ANDTITL 2 ITS IMPLICATIONS FOR DOUBLE-STRAND BREAK REPAIR.REF NATURE V. 412 607 2001REFN ISSN 0028-0836PMID 11493912DOI 10.1038/35088000 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3akm FABP2 x-ray structure of ifabp from human and rat with bound fluorescent fatty acid analogue 1.9Å AUTH A.J.K.LAGUERRE,J.WIELENS,M.W.PARKER,C.J.PORTER,M.J.SCANLONTITL CRYSTAL STRUCTURES OF HUMAN AND RAT INTESTINAL FATTY ACIDTITL 2 BINDING PROTEINS IN COMPLEX WITH 11-(DANSYLAMINO)UNDECANOICTITL 3 ACIDREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1g83 FYN crystal structure of fyn sh3-sh2 2.6Å AUTH S.T.AROLD,T.S.ULMER,T.D.MULHERN,J.M.WERNER,AUTH 2 J.E.LADBURY,I.D.CAMPBELL,M.E.NOBLETITL THE ROLE OF THE SRC HOMOLOGY 3-SRC HOMOLOGY 2TITL 2 INTERFACE IN THE REGULATION OF SRC KINASES.REF J.BIOL.CHEM. V. 276 17199 2001REFN ISSN 0021-9258PMID 11278857DOI 10.1074/JBC.M011185200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ova C8G x-ray structure of human complement protein c8gamma y83w mutant 1.5Å AUTH B.CHISWELL,L.L.LOVELACE,C.BRANNEN,E.A.ORTLUND,AUTH 2 L.LEBIODA,J.M.SODETZTITL STRUCTURAL FEATURES OF THE LIGAND BINDING SITE ONTITL 2 HUMAN COMPLEMENT PROTEIN C8GAMMA: A MEMBER OF THETITL 3 LIPOCALIN FAMILYREF BIOCHIM.BIOPHYS.ACTA V.1774 637 2007REFN ISSN 0006-3002PMID 17452033DOI 10.1016/J.BBAPAP.2007.03.004 Variant Set Distributions Mapped Variants
General Structure Information 2v5o IGF2R structure of human igf2r domains 11-14 2.91Å AUTH J.BROWN,C.DELAINE,O.J.ZACCHEO,C.SIEBOLD,R.J.GILBERT,AUTH 2 G.VAN BOXEL,A.DENLEY,J.C.WALLACE,A.B.HASSAN,B.E.FORBES,AUTH 3 E.Y.JONESTITL STRUCTURE AND FUNCTIONAL ANALYSIS OF THE IGF-II/IGF2RTITL 2 INTERACTIONREF EMBO J. V. 27 265 2008REFN ISSN 0261-4189PMID 18046459DOI 10.1038/SJ.EMBOJ.7601938 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1umk CYB5R3 the structure of human erythrocyte nadh-cytochrome b5 reductase 1.75Å AUTH S.BANDO,T.TAKANO,T.YUBISUI,K.SHIRABE,M.TAKESHITA,AUTH 2 A.NAKAGAWATITL STRUCTURE OF HUMAN ERYTHROCYTE NADH-CYTOCHROME B5TITL 2 REDUCTASE.REF ACTA CRYSTALLOGR.,SECT.D V. 60 1929 2004REFN ISSN 0907-4449PMID 15502298DOI 10.1107/S0907444904020645 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3qkg AMBP crystal structure of alpha-1-microglobulin at 2.3 a resolution 2.3Å AUTH W.MEINING,A.SKERRATITL THE CRYSTAL STRUCTURE OF HUMAN ALPHA(1)-MICROGLOBULINTITL 2 REVEALS A POTENTIAL HAEM-BINDING SITE.REF BIOCHEM.J. V. 445 175 2012REFN ISSN 0264-6021PMID 22512701DOI 10.1042/BJ20120448 Variant Set Distributions Mapped Variants
General Structure Information 2v5p IGF2 complex structure of human igf2r domains 11-13 bound to igf-ii 4.1Å AUTH J.BROWN,C.DELAINE,O.J.ZACCHEO,C.SIEBOLD,AUTH 2 R.J.GILBERT,G.VAN BOXEL,A.DENLEY,J.C.WALLACE,AUTH 3 A.B.HASSAN,B.E.FORBES,E.Y.JONESTITL STRUCTURE AND FUNCTIONAL ANALYSIS OF THETITL 2 IGF-II/IGF2R INTERACTIONREF EMBO J. V. 27 265 2008REFN ISSN 0261-4189PMID 18046459DOI 10.1038/SJ.EMBOJ.7601938 Variant Set Distributions Mapped Variants