Assessment of Structural Intolerance and Durability
General Structure Information 2vwf GAB2 grb2 sh3c (2) 1.58Å AUTH M.HARKIOLAKI,T.TSIRKA,M.LEWITZKY,P.C.SIMISTER,AUTH 2 D.JOSHI,L.E.BIRD,E.Y.JONES,N.OREILLY,S.M.FELLERTITL DISTINCT BINDING MODES OF TWO EPITOPES IN GAB2TITL 2 THAT INTERACT WITH THE SH3C DOMAIN OF GRB2.REF STRUCTURE V. 17 809 2009REFN ISSN 0969-2126PMID 19523899DOI 10.1016/J.STR.2009.03.017 Variant Set Distributions Mapped Variants
General Structure Information 2zmv TRAPPC4 crystal structure of synbindin 2.8Å AUTH S.FAN,Z.WEI,H.XU,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN SYNBINDIN REVEALS TWOTITL 2 CONFORMATIONS OF LONGIN DOMAINREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 378 338 2009REFN ISSN 0006-291XPMID 18466758DOI 10.1016/J.BBRC.2008.04.143 Variant Set Distributions Mapped Variants
General Structure Information 3kn1 GOLPH3 crystal structure of golgi phosphoprotein 3 n-term truncation variant 2.9Å AUTH C.S.WOOD,K.R.SCHMITZ,N.J.BESSMAN,T.G.SETTY,AUTH 2 K.M.FERGUSON,C.G.BURDTITL PTDINS4P RECOGNITION BY VPS74/GOLPH3 LINKS PTDINSTITL 2 4-KINASE SIGNALING TO RETROGRADE GOLGI TRAFFICKING.REF J.CELL BIOL. V. 187 967 2009REFN ISSN 0021-9525PMID 20026658DOI 10.1083/JCB.200909063 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4aiw GLIPR2 gapr-1 with bound inositol hexakisphosphate 1.5Å AUTH J.VAN GALEN,N.K.OLRICHS,A.SCHOUTEN,R.L.SERRANO,AUTH 2 E.N.M.NOLTE-T HOEN,R.EERLAND,D.KALOYANOVA,P.GROS,J.B.HELMSTITL INTERACTION OF GAPR-1 WITH LIPID BILAYERS IS REGULATED BYTITL 2 ALTERNATIVE HOMODIMERIZATION.REF BIOCHIM.BIOPHYS.ACTA V.1818 2175 2012REFN ISSN 0006-3002PMID 22560898DOI 10.1016/J.BBAMEM.2012.04.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jam CAMK1G crystal structure of human calmodulin-dependent protein kinase i g 1.7Å AUTH J.E.DEBRECZENI,A.BULLOCK,T.KEATES,F.H.NIESEN,AUTH 2 E.SALAH,L.SHRESTHA,C.SMEE,F.SOBOTT,A.C.W.PIKE,AUTH 3 G.BUNKOCZI,F.VON DELFT,A.TURNBULL,J.WEIGELT,AUTH 4 C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE I GREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f6k SORT1 crystal structure of the vps10p domain of human sortilin/nts3 in complex with neurotensin 2.0Å AUTH E.M.QUISTGAARD,P.MADSEN,M.K.GROFTEHAUGE,P.NISSEN,AUTH 2 C.M.PETERSEN,S.S.THIRUPTITL LIGANDS BIND TO SORTILIN IN THE TUNNEL OF A TEN-BLADEDTITL 2 BETA-PROPELLER DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 16 96 2009REFN ISSN 1545-9993PMID 19122660DOI 10.1038/NSMB.1543 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3bd9 HS3ST5 human 3-o-sulfotransferase isoform 5 with bound pap 2.3Å AUTH D.XU,A.F.MOON,D.SONG,L.C.PEDERSEN,J.LIUTITL ENGINEERING SULFOTRANSFERASES TO MODIFY HEPARANTITL 2 SULFATE.REF NAT.CHEM.BIOL. V. 4 200 2008REFN ISSN 1552-4450PMID 18223645DOI 10.1038/NCHEMBIO.66 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3eu9 ZDHHC17 the ankyrin repeat domain of huntingtin interacting protein 14 1.99Å AUTH T.GAO,R.E.COLLINS,J.R.HORTON,X.ZHANG,R.ZHANG,A.DHAYALAN,AUTH 2 R.TAMAS,A.JELTSCH,X.CHENGTITL THE ANKYRIN REPEAT DOMAIN OF HUNTINGTIN INTERACTING PROTEINTITL 2 14 CONTAINS A SURFACE AROMATIC CAGE, A POTENTIAL SITE FORTITL 3 METHYL-LYSINE BINDING.REF PROTEINS V. 76 772 2009REFN ISSN 0887-3585PMID 19434754DOI 10.1002/PROT.22452 Variant Set Distributions Mapped Variants
General Structure Information 3a4u MCFD2 crystal structure of mcfd2 in complex with carbohydrate recognition domain of ergic-53 1.84Å AUTH M.NISHIO,Y.KAMIYA,T.MIZUSHIMA,S.WAKATSUKI,H.SASAKAWA,AUTH 2 K.YAMAMOTO,S.UCHIYAMA,M.NODA,A.R.MCKAY,K.FUKUI,H.P.HAURI,AUTH 3 K.KATOTITL STRUCTURAL BASIS FOR THE COOPERATIVE INTERPLAY BETWEEN THETITL 2 TWO CAUSATIVE GENE PRODUCTS OF COMBINED FACTOR V AND FACTORTITL 3 VIII DEFICIENCY.REF PROC.NATL.ACAD.SCI.USA V. 107 4034 2010REFN ISSN 0027-8424PMID 20142513DOI 10.1073/PNAS.0908526107 […]
General Structure Information 3bbp GCC2 rab6-gtp:gcc185 rab binding domain complex 3.0Å AUTH A.S.BURGUETE,T.D.FENN,A.T.BRUNGER,S.R.PFEFFERTITL RAB AND ARL GTPASE FAMILY MEMBERS COOPERATE IN THETITL 2 LOCALIZATION OF THE GOLGIN GCC185.REF CELL(CAMBRIDGE,MASS.) V. 132 286 2008REFN ISSN 0092-8674PMID 18243103DOI 10.1016/J.CELL.2007.11.048 Variant Set Distributions Mapped Variants