General Structure Information 3hy4 MTHFS structure of human mthfs with n5-iminium phosphate 2.79Å AUTH D.WU,Y.LI,G.SONG,C.CHENG,R.ZHANG,A.JOACHIMIAK,AUTH 2 N.SHAW,Z.-J.LIUTITL STRUCTURAL BASIS FOR THE INHIBITION OF HUMANTITL 2 5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE BYTITL 3 N10-SUBSTITUTED FOLATE ANALOGUESREF CANCER RES. V. 69 7294 2009REFN ISSN 0008-5472PMID 19738041DOI 10.1158/0008-5472.CAN-09-1927 Variant Set Distributions Mapped Variants
General Structure Information 1juj TYMS human thymidylate synthase bound to dump and ly231514, a pyrrolo(2,3-d)pyrimidine-based antifolate 3.0Å AUTH P.H.SAYRE,J.S.FINER-MOORE,T.A.FRITZ,D.BIERMANN,AUTH 2 S.B.GATES,W.C.MACKELLAR,V.F.PATEL,R.M.STROUDTITL MULTI-TARGETED ANTIFOLATES AIMED AT AVOIDING DRUGTITL 2 RESISTANCE FORM COVALENT CLOSED INHIBITORYTITL 3 COMPLEXES WITH HUMAN AND ESCHERICHIA COLITITL 4 THYMIDYLATE SYNTHASES.REF J.MOL.BIOL. V. 313 813 2001REFN ISSN 0022-2836PMID 11697906DOI 10.1006/JMBI.2001.5074 Variant Set Distributions […]