Assessment of Structural Intolerance and Durability
General Structure Information 2f37 TRPV2 crystal structure of the ankyrin repeat domain of human trpv2 1.7Å AUTH C.J.MCCLEVERTY,E.KOESEMA,A.PATAPOUTIAN,S.A.LESLEY,AUTH 2 A.KREUSCHTITL CRYSTAL STRUCTURE OF THE HUMAN TRPV2 CHANNELTITL 2 ANKYRIN REPEAT DOMAIN.REF PROTEIN SCI. V. 15 2201 2006REFN ISSN 0961-8368PMID 16882997DOI 10.1110/PS.062357206 Variant Set Distributions Mapped Variants
General Structure Information 4lg6 ANKRA2 crystal structure of ankra2-ccdc8 complex 1.8Å AUTH J.NIE,C.XU,J.JIN,J.A.AKA,W.TEMPEL,V.NGUYEN,L.YOU,R.WEIST,AUTH 2 J.MIN,T.PAWSON,X.J.YANGTITL ANKYRIN REPEATS OF ANKRA2 RECOGNIZE A PXLPXL MOTIF ON THE 3MTITL 2 SYNDROME PROTEIN CCDC8.REF STRUCTURE V. 23 700 2015REFN ISSN 0969-2126PMID 25752541DOI 10.1016/J.STR.2015.02.001 Variant Set Distributions Mapped Variants
General Structure Information 3twr TNKS2 crystal structure of arc4 from human tankyrase 2 in complex with peptide from human 3bp2 1.55Å AUTH S.GUETTLER,J.LAROSE,E.PETSALAKI,G.GISH,A.SCOTTER,T.PAWSON,AUTH 2 R.ROTTAPEL,F.SICHERITITL STRUCTURAL BASIS AND SEQUENCE RULES FOR SUBSTRATETITL 2 RECOGNITION BY TANKYRASE EXPLAIN THE BASIS FOR CHERUBISMTITL 3 DISEASE.REF CELL(CAMBRIDGE,MASS.) V. 147 1340 2011REFN ISSN 0092-8674PMID 22153077DOI 10.1016/J.CELL.2011.10.046 Variant Set Distributions […]
General Structure Information 4dx1 TRPV4 crystal structure of the human trpv4 ankyrin repeat domain 2.85Å AUTH H.INADA,E.PROCKO,M.SOTOMAYOR,R.GAUDETTITL STRUCTURAL AND BIOCHEMICAL CONSEQUENCES OF DISEASE-CAUSINGTITL 2 MUTATIONS IN THE ANKYRIN REPEAT DOMAIN OF THE HUMAN TRPV4TITL 3 CHANNEL.REF BIOCHEMISTRY V. 51 6195 2012REFN ISSN 0006-2960PMID 22702953DOI 10.1021/BI300279B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3b7b EHMT1 euhmt1 (glp) ankyrin repeat domain (structure 1) 2.99Å AUTH R.E.COLLINS,J.P.NORTHROP,J.R.HORTON,D.Y.LEE,AUTH 2 X.ZHANG,M.R.STALLCUP,X.CHENGTITL THE ANKYRIN REPEATS OF G9A AND GLP HISTONETITL 2 METHYLTRANSFERASES ARE MONO- AND DIMETHYLLYSINETITL 3 BINDING MODULESREF NAT.STRUCT.MOL.BIOL. V. 15 245 2008REFN ISSN 1545-9993PMID 18264113DOI 10.1038/NSMB.1384 Variant Set Distributions Mapped Variants
General Structure Information 3c5r BARD1 crystal structure of the bard1 ankyrin repeat domain and its functional consequences 2.0Å AUTH D.FOX,I.LE TRONG,P.RAJAGOPAL,P.S.BRZOVIC,R.E.STENKAMP,AUTH 2 R.E.KLEVITTITL CRYSTAL STRUCTURE OF THE BARD1 ANKYRIN REPEAT DOMAIN AND ITSTITL 2 FUNCTIONAL CONSEQUENCES.REF J.BIOL.CHEM. V. 283 21179 2008REFN ISSN 0021-9258PMID 18480049DOI 10.1074/JBC.M802333200 Variant Set Distributions Mapped Variants
General Structure Information 2vge PPP1R13L crystal structure of the c-terminal region of human iaspp 2.1Å AUTH R.A.ROBINSON,X.LU,E.Y.JONES,C.SIEBOLDTITL BIOCHEMICAL AND STRUCTURAL STUDIES OF ASPPTITL 2 PROTEINS REVEAL DIFFERENTIAL BINDING TO P53, P63TITL 3 AND P73REF STRUCTURE V. 16 259 2008REFN ISSN 0969-2126PMID 18275817DOI 10.1016/J.STR.2007.11.012 Variant Set Distributions Mapped Variants
General Structure Information 2cod ARAP2 solution structure of the n-terminal ph domain of arap2 protein from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL PH DOMAIN OFTITL 2 ARAP2 PROTEIN FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3eu9 ZDHHC17 the ankyrin repeat domain of huntingtin interacting protein 14 1.99Å AUTH T.GAO,R.E.COLLINS,J.R.HORTON,X.ZHANG,R.ZHANG,A.DHAYALAN,AUTH 2 R.TAMAS,A.JELTSCH,X.CHENGTITL THE ANKYRIN REPEAT DOMAIN OF HUNTINGTIN INTERACTING PROTEINTITL 2 14 CONTAINS A SURFACE AROMATIC CAGE, A POTENTIAL SITE FORTITL 3 METHYL-LYSINE BINDING.REF PROTEINS V. 76 772 2009REFN ISSN 0887-3585PMID 19434754DOI 10.1002/PROT.22452 Variant Set Distributions Mapped Variants
General Structure Information 3ixe LIMS2 structural basis of competition between pinch1 and pinch2 for binding to the ankyrin repeat domain of integrin-linked kinase 1.9Å AUTH B.P.CHISWELL,A.L.STIEGLER,Z.RAZINIA,E.NALIBOTSKI,AUTH 2 T.J.BOGGON,D.A.CALDERWOODTITL STRUCTURAL BASIS OF COMPETITION BETWEEN PINCH1 ANDTITL 2 PINCH2 FOR BINDING TO THE ANKYRIN REPEAT DOMAIN OFTITL 3 INTEGRIN-LINKED KINASE.REF J.STRUCT.BIOL. V. 170 157 2010REFN ISSN 1047-8477PMID […]