Assessment of Structural Intolerance and Durability
General Structure Information 2l7b APOE nmr structure of full length apoe3 -1.0Å AUTH J.CHEN,Q.LI,J.WANGTITL TOPOLOGY OF HUMAN APOLIPOPROTEIN E3 UNIQUELY REGULATES ITSTITL 2 DIVERSE BIOLOGICAL FUNCTIONS.REF PROC.NATL.ACAD.SCI.USA V. 108 14813 2011REFN ISSN 0027-8424PMID 21873229DOI 10.1073/PNAS.1106420108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lp1 APP the solution nmr structure of the transmembrane c-terminal domain of the amyloid precursor protein (c99) -1.0Å AUTH P.J.BARRETT,Y.SONG,W.D.VAN HORN,E.J.HUSTEDT,J.M.SCHAFER,AUTH 2 A.HADZISELIMOVIC,A.J.BEEL,C.R.SANDERSTITL THE AMYLOID PRECURSOR PROTEIN HAS A FLEXIBLE TRANSMEMBRANETITL 2 DOMAIN AND BINDS CHOLESTEROL.REF SCIENCE V. 336 1168 2012REFN ISSN 0036-8075PMID 22654059DOI 10.1126/SCIENCE.1219988 Variant Set Distributions Mapped Variants
General Structure Information 2dyq APBB3 crystal structure of the c-terminal phophotyrosine interaction domain of human apbb3 3.1Å AUTH S.SAIJO,A.NISHINO,S.KISHISHITA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE C-TERMINAL PHOPHOTYROSINETITL 2 INTERACTION DOMAIN OF HUMAN APBB3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dxc APBB1 crystal structure of the intracellular domain of human app in complex with fe65-ptb2 2.1Å AUTH J.RADZIMANOWSKI,B.SIMON,M.SATTLER,K.BEYREUTHER,AUTH 2 I.SINNING,K.WILDTITL STRUCTURE OF THE INTRACELLULAR DOMAIN OF THETITL 2 AMYLOID PRECURSOR PROTEIN IN COMPLEX WITHTITL 3 FE65-PTB2.REF EMBO REP. V. 9 1134 2008REFN ISSN 1469-221XPMID 18833287DOI 10.1038/EMBOR.2008.188 Variant Set Distributions Mapped Variants