Assessment of Structural Intolerance and Durability
General Structure Information 2kiv ANKS1B aida-1 sam domain tandem -1.0Å AUTH A.KURABI,S.BRENER,M.MOBLI,J.J.KWAN,L.W.DONALDSONTITL A NUCLEAR LOCALIZATION SIGNAL AT THE SAM-SAM DOMAINTITL 2 INTERFACE OF AIDA-1 SUGGESTS A REQUIREMENT FORTITL 3 DOMAIN UNCOUPLING PRIOR TO NUCLEAR IMPORT.REF J.MOL.BIOL. V. 392 1168 2009REFN ISSN 0022-2836PMID 19666031DOI 10.1016/J.JMB.2009.08.004 Variant Set Distributions Mapped Variants
General Structure Information 3dl2 UEVLD hexagonal structure of the ldh domain of human ubiquitin- conjugating enzyme e2-like isoform a 2.1Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,E.M.NEWMAN,AUTH 2 P.J.FINERTY JR.,C.BUTLER-COLE,C.BOUNTRA,AUTH 3 M.WOLKSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 4 S.DHE-PAGANONTITL STRUCTURAL INVESTIGATION INTO THE L-LACTATETITL 2 DEHYDROGENASE DOMAIN OF HUMANTITL 3 UBIQUITIN-CONJUGATING ENZYME E2-LIKE ISOFORM A.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wqz NLGN4X crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement 3.9Å AUTH I.P.FABRICHNY,P.LEONE,G.SULZENBACHER,D.COMOLETTI,M.T.MILLER,AUTH 2 P.TAYLOR,Y.BOURNE,P.MARCHOTTITL STRUCTURAL ANALYSIS OF THE SYNAPTIC PROTEIN NEUROLIGIN ANDTITL 2 ITS BETA-NEUREXIN COMPLEX: DETERMINANTS FOR FOLDING ANDTITL 3 CELL ADHESION.REF NEURON V. 56 979 2007REFN ISSN 0896-6273PMID 18093521DOI 10.1016/J.NEURON.2007.11.013 Variant Set Distributions Ripley’s […]
General Structure Information 3kt9 APTX aprataxin fha domain 1.65Å AUTH O.J.BECHEREL,B.JAKOB,A.L.CHERRY,N.GUEVEN,M.FUSSER,AUTH 2 A.W.KIJAS,C.PENG,S.KATYAL,P.J.MCKINNON,J.CHEN,AUTH 3 B.EPE,S.J.SMERDON,G.TAUCHER-SCHOLZ,M.F.LAVINTITL CK2 PHOSPHORYLATION-DEPENDENT INTERACTION BETWEENTITL 2 APRATAXIN AND MDC1 IN THE DNA DAMAGE RESPONSE.REF NUCLEIC ACIDS RES. V. 38 1489 2010REFN ISSN 0305-1048PMID 20008512DOI 10.1093/NAR/GKP1149 Variant Set Distributions Mapped Variants
General Structure Information 2zb7 PTGR2 crystal structure of human 15-ketoprostaglandin delta-13- reductase in complex with nadph and nicotinamide 1.8Å AUTH Y.H.WU,T.P.KO,R.T.GUO,S.M.HU,L.M.CHUANG,A.H.J.WANGTITL STRUCTURAL BASIS FOR CATALYTIC AND INHIBITORYTITL 2 MECHANISMS OF HUMAN PROSTAGLANDIN REDUCTASE PTGR2.REF STRUCTURE V. 16 1714 2008REFN ISSN 0969-2126PMID 19000823DOI 10.1016/J.STR.2008.09.007 Variant Set Distributions Mapped Variants
General Structure Information 2k2m EPS8L1 structural basis of pxxdy motif recognition in sh3 binding -1.0Å AUTH O.AITIO,M.HELLMAN,T.KESTI,I.KLEINO,O.SAMUILOVA,AUTH 2 K.PAAKKONEN,H.TOSSAVAINEN,K.SAKSELA,P.PERMITITL STRUCTURAL BASIS OF PXXDY MOTIF RECOGNITION IN SH3TITL 2 BINDING.REF J.MOL.BIOL. V. 382 167 2008REFN ISSN 0022-2836PMID 18644376DOI 10.1016/J.JMB.2008.07.008 Variant Set Distributions Mapped Variants
General Structure Information 3ixe LIMS2 structural basis of competition between pinch1 and pinch2 for binding to the ankyrin repeat domain of integrin-linked kinase 1.9Å AUTH B.P.CHISWELL,A.L.STIEGLER,Z.RAZINIA,E.NALIBOTSKI,AUTH 2 T.J.BOGGON,D.A.CALDERWOODTITL STRUCTURAL BASIS OF COMPETITION BETWEEN PINCH1 ANDTITL 2 PINCH2 FOR BINDING TO THE ANKYRIN REPEAT DOMAIN OFTITL 3 INTEGRIN-LINKED KINASE.REF J.STRUCT.BIOL. V. 170 157 2010REFN ISSN 1047-8477PMID […]
General Structure Information 2kom PARD3 solution structure of humar par-3b pdz2 (residues 451-549) -1.0Å AUTH D.R.JENSEN,C.WOYTOVICH,M.LI,P.DUVNJAK,M.S.CASSIDY,AUTH 2 R.O.FREDERICK,L.F.BERGEMAN,F.C.PETERSON,B.F.VOLKMANTITL RAPID, ROBOTIC, SMALL-SCALE PROTEIN PRODUCTION FORTITL 2 NMR SCREENING AND STRUCTURE DETERMINATION.REF PROTEIN SCI. V. 19 570 2010REFN ISSN 0961-8368PMID 20073081DOI 10.1002/PRO.335 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jxx NFATC2IP nmr solution structure of ubiquitin-like domain of nfatc2ip. northeast structural genomics consortium target hr5627 -1.0Å AUTH R.S.DOHERTY,S.DHE-PAGANON,C.FARES,A.LEMAK,C.BUTLER,AUTH 2 S.SRISAILAM,M.KARRA,A.YEE,J.WEIGELT,A.M.EDWARDS,AUTH 3 C.H.ARROWSMITHTITL SOLUTION STRUCTURE OF UBIQUITIN-LIKE DOMAIN OFTITL 2 NFATC2IP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2uzg USP33 zf-ubp domain of vdu1 -1.0Å AUTH M.D.ALLEN,M.BYCROFTTITL THE SOLUTION STRUCTURE OF THE ZNF UBP DOMAIN OFTITL 2 USP33/VDU1.REF PROTEIN SCI. V. 16 2072 2007REFN ISSN 0961-8368PMID 17766394DOI 10.1110/PS.072967807 Variant Set Distributions Mapped Variants