Assessment of Structural Intolerance and Durability
General Structure Information 2jxd SPINK2 nmr structure of human serine protease inhibitor kazal type ii (spink2) -1.0Å AUTH T.CHEN,T.-R.LEE,W.-G.LIANG,W.-S.W.CHANG,P.-C.LYUTITL IDENTIFICATION OF TRYPSIN-INHIBITORY SITE ANDTITL 2 STRUCTURE DETERMINATION OF HUMAN SPINK2 SERINETITL 3 PROTEINASE INHIBITORREF PROTEINS V. 77 209 2009REFN ISSN 0887-3585PMID 19422058DOI 10.1002/PROT.22432 Variant Set Distributions Mapped Variants
General Structure Information 1g83 FYN crystal structure of fyn sh3-sh2 2.6Å AUTH S.T.AROLD,T.S.ULMER,T.D.MULHERN,J.M.WERNER,AUTH 2 J.E.LADBURY,I.D.CAMPBELL,M.E.NOBLETITL THE ROLE OF THE SRC HOMOLOGY 3-SRC HOMOLOGY 2TITL 2 INTERFACE IN THE REGULATION OF SRC KINASES.REF J.BIOL.CHEM. V. 276 17199 2001REFN ISSN 0021-9258PMID 11278857DOI 10.1074/JBC.M011185200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3lbx SPTB crystal structure of the erythrocyte spectrin tetramerization domain complex 2.8Å AUTH J.J.IPSARO,S.L.HARPER,T.E.MESSICK,R.MARMORSTEIN,A.MONDRAGON,AUTH 2 D.W.SPEICHERTITL CRYSTAL STRUCTURE AND FUNCTIONAL INTERPRETATION OF THETITL 2 ERYTHROCYTE SPECTRIN TETRAMERIZATION DOMAIN COMPLEX.REF BLOOD V. 115 4843 2010REFN ISSN 0006-4971PMID 20197550DOI 10.1182/BLOOD-2010-01-261396 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2p6v TAF4 structure of tafh domain of the human taf4 subunit of tfiid 2.0Å AUTH X.WANG,D.M.TRUCKSES,S.TAKADA,T.MATSUMURA,N.TANESE,AUTH 2 R.H.JACOBSONTITL CONSERVED REGION I OF HUMAN COACTIVATOR TAF4 BINDSTITL 2 TO A SHORT HYDROPHOBIC MOTIF PRESENT INTITL 3 TRANSCRIPTIONAL REGULATORS.REF PROC.NATL.ACAD.SCI.USA V. 104 7839 2007REFN ISSN 0027-8424PMID 17483474DOI 10.1073/PNAS.0608570104 Variant Set Distributions Mapped Variants