Assessment of Structural Intolerance and Durability
General Structure Information 3bn3 ICAM5 crystal structure of icam-5 in complex with al i domain 2.1Å AUTH H.ZHANG,J.M.CASASNOVAS,M.JIN,J.H.LIU,C.G.GAHMBERG,AUTH 2 T.A.SPRINGER,J.-H.WANGTITL AN UNUSUAL ALLOSTERIC MOBILITY OF THE C-TERMINAL HELIX OF ATITL 2 HIGH-AFFINITY ALPHA L INTEGRIN I DOMAIN VARIANT BOUND TOTITL 3 ICAM-5REF MOL.CELL V. 31 432 2008REFN ISSN 1097-2765PMID 18691975DOI 10.1016/J.MOLCEL.2008.06.022 Variant Set Distributions Mapped […]
General Structure Information 2jam CAMK1G crystal structure of human calmodulin-dependent protein kinase i g 1.7Å AUTH J.E.DEBRECZENI,A.BULLOCK,T.KEATES,F.H.NIESEN,AUTH 2 E.SALAH,L.SHRESTHA,C.SMEE,F.SOBOTT,A.C.W.PIKE,AUTH 3 G.BUNKOCZI,F.VON DELFT,A.TURNBULL,J.WEIGELT,AUTH 4 C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE I GREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4or2 GRM1 human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator 2.8Å AUTH H.WU,C.WANG,K.J.GREGORY,G.W.HAN,H.P.CHO,Y.XIA,C.M.NISWENDER,AUTH 2 V.KATRITCH,J.MEILER,V.CHEREZOV,P.J.CONN,R.C.STEVENSTITL STRUCTURE OF A CLASS C GPCR METABOTROPIC GLUTAMATE RECEPTORTITL 2 1 BOUND TO AN ALLOSTERIC MODULATORREF SCIENCE V. 344 58 2014REFN ISSN 0036-8075PMID 24603153DOI 10.1126/SCIENCE.1249489 Variant Set Distributions Ripley’s […]
General Structure Information 4or2 GRM1 human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator 2.8Å AUTH H.WU,C.WANG,K.J.GREGORY,G.W.HAN,H.P.CHO,Y.XIA,C.M.NISWENDER,AUTH 2 V.KATRITCH,J.MEILER,V.CHEREZOV,P.J.CONN,R.C.STEVENSTITL STRUCTURE OF A CLASS C GPCR METABOTROPIC GLUTAMATE RECEPTORTITL 2 1 BOUND TO AN ALLOSTERIC MODULATORREF SCIENCE V. 344 58 2014REFN ISSN 0036-8075PMID 24603153DOI 10.1126/SCIENCE.1249489 Variant Set Distributions Ripley’s […]
General Structure Information 4or2 GRM1 human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator 2.8Å AUTH H.WU,C.WANG,K.J.GREGORY,G.W.HAN,H.P.CHO,Y.XIA,C.M.NISWENDER,AUTH 2 V.KATRITCH,J.MEILER,V.CHEREZOV,P.J.CONN,R.C.STEVENSTITL STRUCTURE OF A CLASS C GPCR METABOTROPIC GLUTAMATE RECEPTORTITL 2 1 BOUND TO AN ALLOSTERIC MODULATORREF SCIENCE V. 344 58 2014REFN ISSN 0036-8075PMID 24603153DOI 10.1126/SCIENCE.1249489 Variant Set Distributions Ripley’s […]
General Structure Information 3hm8 HK3 crystal structure of the c-terminal hexokinase domain of human hk3 2.8Å AUTH L.NEDYALKOVA,Y.TONG,W.RABEH,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE C-TERMINAL HEXOKINASE DOMAIN OFTITL 2 HUMAN HK3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ne7 GNPDA1 human glucosamine-6-phosphate deaminase isomerase at 1.75 a resolution complexed with n-acetyl-glucosamine-6-phosphate and 2-deoxy-2-amino-glucitol-6-phosphate 1.75Å AUTH R.ARREOLA,B.VALDERRAMA,M.L.MORANTE,E.HORJALESTITL TWO MAMMALIAN GLUCOSAMINE-6-PHOSPHATE DEAMINASES:TITL 2 A STRUCTURAL AND GENETIC STUDY.REF FEBS LETT. V. 551 63 2003REFN ISSN 0014-5793PMID 12965206DOI 10.1016/S0014-5793(03)00896-2 Variant Set Distributions Mapped Variants
General Structure Information 3jwq PDE6C crystal structure of chimeric pde5/pde6 catalytic domain complexed with sildenafil 2.87Å AUTH B.BARREN,L.GAKHAR,H.MURADOV,K.K.BOYD,S.RAMASWAMY,AUTH 2 N.O.ARTEMYEVTITL STRUCTURAL BASIS OF PHOSPHODIESTERASE 6 INHIBITION BY THETITL 2 C-TERMINAL REGION OF THE GAMMA-SUBUNITREF EMBO J. V. 28 3613 2009REFN ISSN 0261-4189PMID 19798052DOI 10.1038/EMBOJ.2009.284 Variant Set Distributions Mapped Variants
General Structure Information 4ip7 PKLR structure of the s12d variant of human liver pyruvate kinase in complex with citrate and fbp. 1.8Å AUTH T.HOLYOAK,B.ZHANG,J.DENG,Q.TANG,C.B.PRASANNAN,A.W.FENTONTITL ENERGETIC COUPLING BETWEEN AN OXIDIZABLE CYSTEINE AND THETITL 2 PHOSPHORYLATABLE N-TERMINUS OF HUMAN LIVER PYRUVATE KINASE.REF BIOCHEMISTRY V. 52 466 2013REFN ISSN 0006-2960PMID 23270483DOI 10.1021/BI301341R Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3alo MAP2K4 crystal structure of human non-phosphorylated mkk4 kinase domain ternary complex with amp-pnp and p38 peptide 2.6Å AUTH T.MATSUMOTO,T.KINOSHITA,Y.KIRII,K.YOKOTA,K.HAMADA,T.TADATITL CRYSTAL STRUCTURES OF MKK4 KINASE DOMAIN REVEAL THATTITL 2 SUBSTRATE PEPTIDE BINDS TO AN ALLOSTERIC SITE AND INDUCES ANTITL 3 AUTO-INHIBITION STATEREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 400 369 2010REFN ISSN 0006-291XPMID 20732303DOI 10.1016/J.BBRC.2010.08.071 Variant […]