Assessment of Structural Intolerance and Durability
General Structure Information 1y8r UBA2 sumo e1 activating enzyme sae1-sae2-sumo1-mg-atp complex 2.75Å AUTH L.M.LOIS,C.D.LIMATITL STRUCTURES OF THE SUMO E1 PROVIDE MECHANISTICTITL 2 INSIGHTS INTO SUMO ACTIVATION AND E2 RECRUITMENTTITL 3 TO E1REF EMBO J. V. 24 439 2005REFN ISSN 0261-4189PMID 15660128DOI 10.1038/SJ.EMBOJ.7600552 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1y8r SAE1 sumo e1 activating enzyme sae1-sae2-sumo1-mg-atp complex 2.75Å AUTH L.M.LOIS,C.D.LIMATITL STRUCTURES OF THE SUMO E1 PROVIDE MECHANISTICTITL 2 INSIGHTS INTO SUMO ACTIVATION AND E2 RECRUITMENTTITL 3 TO E1REF EMBO J. V. 24 439 2005REFN ISSN 0261-4189PMID 15660128DOI 10.1038/SJ.EMBOJ.7600552 Variant Set Distributions Mapped Variants
General Structure Information 1smo TREM1 crystal structure of human triggering receptor expressed on myeloid cells 1 (trem-1) at 1.47 . 1.47Å AUTH M.S.KELKER,T.R.FOSS,W.PETI,L.TEYTON,J.W.KELLY,I.A.WILSONTITL CRYSTAL STRUCTURE OF HUMAN TRIGGERING RECEPTOR EXPRESSED ONTITL 2 MYELOID CELLS 1 (TREM-1) AT 1.47A.REF J.MOL.BIOL. V. 342 1237 2004REFN ISSN 0022-2836PMID 15351648DOI 10.1016/J.JMB.2004.07.089 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2p57 ARFGAP2 gap domain of znf289, an id1-regulated zinc finger protein 1.8Å AUTH Y.TONG,S DIMOV,L.SHEN,H.ZHU,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL GAP DOMAIN OF ZNF289, AN ID1-REGULATED ZINC FINGERTITL 2 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yuy ARHGAP21 solution structure of pdz domain of rho gtpase activating protein 21 -1.0Å AUTH T.N.NIRAULA,M.YONEYAMA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF PDZ DOMAIN OF RHO GTPASETITL 2 ACTIVATING PROTEIN 21REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hzj RABGAP1L crystal structure of the rabgap domain of the rabgap1l protein 2.3Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,N.ZHONG,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF THETITL 2 RABGAP1L PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3aqf CALCRL crystal structure of the human crlr/ramp2 extracellular complex 2.6Å AUTH S.KUSANO,M.KUKIMOTO-NIINO,N.HINO,N.OHSAWA,K.OKUDA,AUTH 2 K.SAKAMOTO,M.SHIROUZU,T.SHINDO,S.YOKOYAMATITL STRUCTURAL BASIS FOR EXTRACELLULAR INTERACTIONS BETWEENTITL 2 CALCITONIN RECEPTOR-LIKE RECEPTOR AND RECEPTORTITL 3 ACTIVITY-MODIFYING PROTEIN 2 FOR ADRENOMEDULLIN-SPECIFICTITL 4 BINDINGREF PROTEIN SCI. V. 21 199 2012REFN ISSN 0961-8368PMID 22102369DOI 10.1002/PRO.2003 Variant Set Distributions Mapped Variants
General Structure Information 3eap ARHGAP11A crystal structure of the rhogap domain of arhgap11a 2.3Å AUTH Y.SHEN,L.SHEN,Y.TONG,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF ARHGAP11AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dbr NAE1 structural dissection of a gating mechanism preventing misactivation of ubiquitin by nedd8s e1 (appbp1- uba3arg190gln-nedd8ala72arg) 3.05Å AUTH J.SOUPHRON,M.B.WADDELL,A.PAYDAR,Z.TOKGOZ-GROMLEY,AUTH 2 M.F.ROUSSEL,B.A.SCHULMANTITL STRUCTURAL DISSECTION OF A GATING MECHANISMTITL 2 PREVENTING MISACTIVATION OF UBIQUITIN BY NEDD8STITL 3 E1.REF BIOCHEMISTRY V. 47 8961 2008REFN ISSN 0006-2960PMID 18652489DOI 10.1021/BI800604C Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2e5o TRIP4 solution structure of the trip_4c domain of target of activating signal cointegrator 1 -1.0Å AUTH W.DANG,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE TRIP_4C DOMAIN OF TARGETTITL 2 OF ACTIVATING SIGNAL COINTEGRATOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants