Assessment of Structural Intolerance and Durability
General Structure Information 2oud DUSP10 crystal structure of the catalytic domain of human mkp5 2.8Å AUTH X.TAO,L.TONGTITL CRYSTAL STRUCTURE OF THE MAP KINASE BINDING DOMAINTITL 2 AND THE CATALYTIC DOMAIN OF HUMAN MKP5.REF PROTEIN SCI. V. 16 880 2007REFN ISSN 0961-8368PMID 17400920DOI 10.1110/PS.062712807 Variant Set Distributions Mapped Variants
General Structure Information 1rx0 ACAD8 crystal structure of isobutyryl-coa dehydrogenase complexed with substrate/ligand. 1.77Å AUTH K.P.BATTAILE,T.V.NGUYEN,J.VOCKLEY,J.J.KIMTITL STRUCTURES OF ISOBUTYRYL-COA DEHYDROGENASE ANDTITL 2 ENZYME-PRODUCT COMPLEX: COMPARISON WITHTITL 3 ISOVALERYL- AND SHORT-CHAIN ACYL-COATITL 4 DEHYDROGENASES.REF J.BIOL.CHEM. V. 279 16526 2004REFN ISSN 0021-9258PMID 14752098DOI 10.1074/JBC.M400034200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2oju PPIL3 x-ray structure of complex of human cyclophilin j with cyclosporin a 2.4Å AUTH J.CHEN,S.CHEN,L.HUANG,X.ZHAO,J.TAN,C.HUANG,H.SAIYIN,M.ZHANG,AUTH 2 X.ZENG,J.XI,B.WAN,Y.ZHAO,Z.XIA,H.JIANG,Q.YI,J.O.LIU,L.YUTITL TARGETING CYCLOPHILIN J, A NOVEL PEPTIDYL-PROLYL ISOMERASE,TITL 2 CAN INDUCE CELLULAR G1/S ARREST AND REPRESS THE GROWTH OFTITL 3 HEPATOCELLULAR CARCINOMAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c43 AASDHPPT structure of aminoadipate-semialdehyde dehydrogenase- phosphopantetheinyl transferase in complex with coenzyme a 1.93Å AUTH G.BUNKOCZI,S.PASTA,A.JOSHI,X.WU,K.L.KAVANAGH,S.SMITH,AUTH 2 U.OPPERMANNTITL MECHANISM AND SUBSTRATE RECOGNITION OF HUMAN HOLO ACPTITL 2 SYNTHASE.REF CHEM.BIOL. V. 14 1243 2007REFN ISSN 1074-5521PMID 18022563DOI 10.1016/J.CHEMBIOL.2007.10.013 Variant Set Distributions Mapped Variants
General Structure Information 2dkp PLEKHA5 solution structure of the ph domain of pleckstrin homology domain-containing protein family a member 5 from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PLECKSTRINTITL 2 HOMOLOGY DOMAIN-CONTAINING PROTEIN FAMILY A MEMBERTITL 3 5 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3tht ALKBH8 crystal structure and rna binding properties of the rrm/alkb domains in human abh8, an enzyme catalyzing trna hypermodification, northeast structural genomics consortium target hr5601b 3.01Å AUTH C.PASTORE,I.TOPALIDOU,F.FOROUHAR,A.C.YAN,M.LEVY,J.F.HUNTTITL CRYSTAL STRUCTURE AND RNA BINDING PROPERTIES OF THE RNATITL 2 RECOGNITION MOTIF (RRM) AND ALKB DOMAINS IN HUMAN ALKBTITL 3 HOMOLOG 8 (ABH8), […]
General Structure Information 2dm4 SORL1 solution structure of the second fn3 domain of human sorla/lr11 -1.0Å AUTH T.NAGASHIMA,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FN3 DOMAIN OFTITL 2 HUMAN SORLA/LR11REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rc4 KAT6A crystal structure of the hat domain of the human moz protein 3.0Å AUTH M.A.HOLBERT,T.SIKORSKI,J.CARTEN,D.SNOWFLACK,S.HODAWADEKAR,AUTH 2 R.MARMORSTEINTITL THE HUMAN MONOCYTIC LEUKEMIA ZINC FINGER HISTONETITL 2 ACETYLTRANSFERASE DOMAIN CONTAINS DNA-BINDING ACTIVITYTITL 3 IMPLICATED IN CHROMATIN TARGETING.REF J.BIOL.CHEM. V. 282 36603 2007REFN ISSN 0021-9258PMID 17925393DOI 10.1074/JBC.M705812200 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2m76 CPT1C structure of the regulatory domain of human brain carnitine palmitoyltransferase 1 -1.0Å AUTH S.SAMANTA,A.J.SITU,T.S.ULMERTITL STRUCTURAL CHARACTERIZATION OF THE REGULATORY DOMAIN OFTITL 2 BRAIN CARNITINE PALMITOYLTRANSFERASE 1.REF BIOPOLYMERS V. 101 398 2014REFN ISSN 0006-3525PMID 24037959DOI 10.1002/BIP.22396 Variant Set Distributions Mapped Variants
General Structure Information 3bpt HIBCH crystal structure of human beta-hydroxyisobutyryl-coa hydrolase in complex with quercetin 1.5Å AUTH E.S.PILKA,C.PHILLIPS,O.N.F.KING,K.GUO,F.VON DELFT,AUTH 2 A.C.W.PIKE,C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA-HYDROXYISOBUTYRYL-COATITL 2 HYDROLASE IN COMPLEX WITH QUERCETIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants