Assessment of Structural Intolerance and Durability
General Structure Information 2xv4 POLR3C structure of human rpc62 (partial) 2.95Å AUTH S.LEFEVRE,H.DUMAY-ODELOT,L.EL AYOUBI,A.BUDD,P.LEGRAND,AUTH 2 N.PINAUD,M.TEICHMANN,S.FRIBOURGTITL STRUCTURE-FUNCTION ANALYSIS OF HRPC62 PROVIDES INSIGHTSTITL 2 INTO RNA POLYMERASE III TRANSCRIPTIONREF NAT.STRUCT.MOL.BIOL. V. 18 352 2011REFN ISSN 1545-9993PMID 21358628DOI 10.1038/NSMB.1996 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wft HHIP crystal structure of the human hip ectodomain 2.8Å AUTH B.BISHOP,A.R.ARICESCU,K.HARLOS,C.A.OCALLAGHAN,AUTH 2 E.Y.JONES,C.SIEBOLDTITL STRUCTURAL INSIGHTS INTO HEDGEHOG LIGANDTITL 2 SEQUESTRATION BY THE HUMAN HEDGEHOG-INTERACTINGTITL 3 PROTEIN HIPREF NAT.STRUCT.MOL.BIOL. V. 16 698 2009REFN ISSN 1545-9993PMID 19561611DOI 10.1038/NSMB.1607 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hlt HDHD2 the crystal structure of human haloacid dehalogenase-like hydrolase domain containing 2 (hdhd2) 2.3Å AUTH E.UGOCHUKWU,N.SHAFQAT,W.W.YUE,R.COCKING,J.E.BRAY,AUTH 2 J.R.C.MUNIZ,T.KROJER,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF HUMAN HALOACID DEHALOGENASE-LIKETITL 2 HYDROLASE DOMAIN CONTAINING 2 (HDHD2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bxw CHID1 crystal structure of stabilin-1 interacting chitinase-like protein, si-clp 2.7Å AUTH G.MENG,Y.ZHAO,X.BAI,Y.LIU,T.J.GREEN,M.LUO,X.ZHENGTITL STRUCTURE OF HUMAN STABILIN-1 INTERACTING CHITINASE-LIKETITL 2 PROTEIN (SI-CLP) REVEALS A SACCHARIDE-BINDING CLEFT WITHTITL 3 LOWER SUGAR-BINDING SELECTIVITY.REF J.BIOL.CHEM. V. 285 39898 2010REFN ISSN 0021-9258PMID 20724479DOI 10.1074/JBC.M110.130781 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4b6d RACGAP1 structure of the atypical c1 domain of mgcracgap 2.2Å AUTH S.LEKOMTSEV,K.SU,V.E.PYE,K.BLIGHT,S.SUNDARAMOORTHY,T.TAKAKI,AUTH 2 L.M.COLLINSON,P.CHEREPANOV,N.DIVECHA,M.PETRONCZKITITL CENTRALSPINDLIN LINKS THE MITOTIC SPINDLE TO THE PLASMATITL 2 MEMBRANE DURING CYTOKINESIS.REF NATURE V. 492 276 2012REFN ISSN 0028-0836PMID 23235882DOI 10.1038/NATURE11773 Variant Set Distributions Mapped Variants
General Structure Information 2cop ACBD6 solution structure of rsgi ruh-040, an acbp domain from human cdna -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-040, AN ACBP DOMAINTITL 2 FROM HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ozn RTN4R 1.5a crystal structure of the nogo receptor ligand binding domain reveals a convergent recognition scaffold mediating inhibition of myelination 1.52Å AUTH X.L.HE,J.F.BAZAN,G.MCDERMOTT,J.B.PARK,K.WANG,AUTH 2 M.TESSIER-LAVIGNE,Z.HE,K.C.GARCIATITL STRUCTURE OF THE NOGO RECEPTOR ECTODOMAIN. A RECOGNITIONTITL 2 MODULE IMPLICATED IN MYELIN INHIBITION.REF NEURON V. 38 177 2003REFN ISSN 0896-6273PMID 12718853DOI 10.1016/S0896-6273(03)00232-0 Variant Set Distributions […]
General Structure Information 2yrg TRIM5 solution structure of the b-box domain from tripartite motif-containing protein 5 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE B-BOX DOMAIN FROMTITL 2 TRIPARTITE MOTIF-CONTAINING PROTEIN 5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1jh4 PAIP1 solution structure of the c-terminal pabc domain of human poly(a)-binding protein in complex with the peptide from paip1 -1.0Å AUTH G.KOZLOV,G.DE CRESCENZO,N.S.LIM,N.SIDDIQUI,AUTH 2 D.FANTUS,A.KAHVEJIAN,J.F.TREMPE,D.ELIAS,I.EKIEL,AUTH 3 N.SONENBERG,M.OCONNOR-MCCOURT,K.GEHRINGTITL STRUCTURAL BASIS OF LIGAND RECOGNITION BY PABC, ATITL 2 HIGHLY SPECIFIC PEPTIDE-BINDING DOMAIN FOUND INTITL 3 POLY(A)-BINDING PROTEIN AND A HECT UBIQUITIN LIGASEREF EMBO […]
General Structure Information 3jw0 NEDD4L e2~ubiquitin-hect 3.1Å AUTH H.B.KAMADURAI,J.SOUPHRON,D.C.SCOTT,D.M.DUDA,D.J.MILLER,AUTH 2 D.STRINGER,R.C.PIPER,B.A.SCHULMANTITL INSIGHTS INTO UBIQUITIN TRANSFER CASCADES FROM A STRUCTURETITL 2 OF A UBCH5B APPROXIMATELY UBIQUITIN-HECT(NEDD4L) COMPLEX.REF MOL.CELL V. 36 1095 2009REFN ISSN 1097-2765PMID 20064473DOI 10.1016/J.MOLCEL.2009.11.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants